Larry C. Wienkers

Articles in Scholarly Journals [Incomplete List]

  1. CYP2C9 Protein Interactions with Cytochrome b5: Effects on the Coupling of Catalysis
    Drug Metabolism and Disposition, vol. 35, no. 7, pp. 1174–1181, 2007
  2. Chemical Research in Toxicology, vol. 19, no. 12, pp. 1650–1659, 2006
  3. Mechanism of Inactivation of Human Cytochrome P450 2B6 by Phencyclidine
    Drug Metabolism and Disposition, vol. 34, no. 9, pp. 1523–1529, 2006
  4. The in Vitro Drug Interaction Potential of Dietary Supplements Containing Multiple Herbal Components
    Drug Metabolism and Disposition, vol. 35, no. 2, pp. 185–188, 2006
  5. Predicting in vivo drug interactions from in vitro drug discovery data
    Nature Reviews Drug Discovery, vol. 4, no. 10, Article ID nrd1851, 8 pages, 2005
  6. Catalytic turnover of pyrene by CYP3A4: Evidence that cytochrome directly induces positive cooperativity
    Archives of Biochemistry and Biophysics, 2005
  7. Chemical Research in Toxicology, vol. 17, no. 2, pp. 174–184, 2004
  8. IN VITRO METABOLISM OF CLINDAMYCIN IN HUMAN LIVER AND INTESTINAL MICROSOMES
    Drug Metabolism and Disposition, vol. 31, no. 7, pp. 878–887, 2003
  9. Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations
    Archives of Biochemistry and Biophysics, vol. 410, no. 1, pp. 16–24, 2003
  10. Effect of carbonate anion on cytochrome P450 2D6-mediated metabolism in vitro: the potential role of multiple oxygenating species
    Archives of Biochemistry and Biophysics, vol. 417, no. 2, pp. 165–175, 2003
  11. Journal of Medicinal Chemistry, vol. 46, no. 2, pp. 284–302, 2003
  12. Chemical Research in Toxicology, vol. 16, no. 4, pp. 450–459, 2003
  13. Characterization of bropirimine O -glucuronidation in human liver microsomes
    Xenobiotica, vol. 33, no. 10, pp. 999–1011, 2003
  14. Pyrene·Pyrene Complexes at the Active Site of Cytochrome P450 3A4: Evidence for a Multiple Substrate Binding Site
    Journal of the American Chemical Society, vol. 124, no. 40, pp. 11866–11867, 2002
  15. Factors confounding the successful extrapolation of in vitro CYP3A inhibition information to the in vivo condition
    European Journal of Pharmaceutical Sciences, vol. 15, no. 3, pp. 239–242, 2002
  16. Multiple Cytochrome P450 Enzymes Responsible for the Oxidative Metabolism of the Substituted (S)-3-Phenylpiperidine, (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine Hydrochloride, in Human Liver Microsomes
    Drug Metabolism and Disposition, vol. 30, no. 12, pp. 1372–1377, 2002
  17. Problems associated with in vitro assessment of drug inhibition of CYP3A4 and other P-450 enzymes and its impact on drug discovery
    Journal of Pharmacological and Toxicological Methods, vol. 45, no. 1, pp. 79–84, 2001
  18. Covalent Alteration of the CYP3A4 Active Site: Evidence for Multiple Substrate Binding Domains
    Archives of Biochemistry and Biophysics, vol. 391, no. 1, pp. 49–55, 2001
  19. Identification of cytochrome P4503A as the major subfamily responsible for the metabolism of roquinimex in man
    Xenobiotica, vol. 30, no. 9, pp. 905–914, 2000
  20. Chemical Research in Toxicology, vol. 13, no. 4, pp. 262–270, 2000
  21. In vitro metabolic transformations of 2,4- dipyrrolidinylp yrimidine : a chemical probe for P450-mediated oxidation of tirilazad mesylate
    Xenobiotica, vol. 27, no. 11, pp. 1131–1145, 1997