Kevin M. Coombs
Kevin M. Coombs was born in Rochester, NY, USA, in 1955. He received his B.S. and B.A. degrees in biology and English from the State University of New York at Geneseo, NY, USA, in 1978, and his Ph.D. degree in microbiology from the University of Texas at Austin, Tex, USA, in 1986. After postdoctoral work at the Harvard University, he joined the faculty at the University of Manitoba, Winnipeg, Manitoba, Canada, in 1990. He is presently a Professor of medical microbiology and the Associate Dean of the Faculty of Graduate Studies. His major research interests are to delineate the protein and nucleic acid interactions in nucleoprotein complexes; how these interactions change as a result of, and in turn, are modulated by, conformational transitions that occur during assembly and disassembly, how these processes can be attenuated by antiviral compounds, and how these processes in virus infections contribute to pathogenesis in the host. This work has examined a variety of RNA viruses (Sindbis virus, Reovirus, and Influenza virus) in tissue culture cell systems, in general areas of generation and molecular characterization of assembly-defective reovirus temperature-sensitive mutants; inhibition of virus replication using pharmacologic inhibitors; mass spectrometry-based analyses of protein conformational changes during virus assembly and entry into cells; molecular and sequence characteristics of RNA-dependent, RNA polymerase, and cofactor proteins; development of reovirus as a bioindicator for wastewater and medical instrument disinfection management.
Biography Updated on 5 December 2008