Laurence Fechter

Laurence Fechter has been a Research Scientist at the Jerry L. Pettis Memorial VA Medical Center in Loma Linda, Calif, USA, since 2002 and holds a research professorship in the Department of Surgery at the Loma Linda University School of Medicine. Prior to taking these positions, Dr. Fechter was the Mosier Centennial Professor of Toxicology and Director of the Oklahoma Center for Toxicology at the University of Oklahoma Health Sciences Center. His first academic position was in the Department of Environmental Health Sciences at the Johns Hopkins School of Hygiene and Public Health where he attained the rank of the Professor of Environmental Toxicology. Dr. Fechter obtained his Ph.D. degree from the University of Rochester in the fields of neurosciences/biopsychology and undertook postdoctoral training in the Medical Pharmacology Institute at the University of Uppsala (Sweden) Biomedical Center and in the Environmental Toxicology Division at Hopkins School of Hygiene. Dr. Fechter’s research is focused on understanding mechanisms by which chemical contaminants disrupt the auditory system and potentiate noise-induced hearing loss. This work has entailed studies of carbon monoxide, hydrogen cyanide, acrylonitrile, and organic solvents. A major focus of this research has been on understanding the role of oxidative stress in ototoxicity. Dr. Fechter has also been engaged in studies of manganese neurotoxicity and developmental neurotoxicology.

Biography Updated on 30 January 2008

Personal Home Page

http://www.rtctox.com/fechter.htm

Articles in Scholarly Journals [Incomplete List]

  1. Oxidative stress pathways in the potentiation of noise-induced hearing loss by acrylonitrile
    Hearing Research, vol. 224, no. 1-2, pp. 61–74, 2007
  2. JP-8 Jet Fuel Can Promote Auditory Impairment Resulting From Subsequent Noise Exposure in Rats
    Toxicological Sciences, vol. 98, no. 2, pp. 510–525, 2007
  3. Promotion of Noise-Induced Cochlear Injury by Toluene and Ethylbenzene in the Rat
    Toxicological Sciences, vol. 98, no. 2, pp. 542–551, 2007
  4. Oxidative stress: a potential basis for potentiation of noise-induced hearing loss
    Environmental Toxicology and Pharmacology, vol. 19, no. 3, pp. 543–546, 2005
  5. Foreword
    Environmental Toxicology and Pharmacology, vol. 19, no. 3, pp. 389–389, 2005
  6. Corrigendum to ?The Relationship of Particle Size to Olfactory Nerve Uptake of a Non-Soluble Form of Manganese into Brain? [NeuroToxicology 23 (2) (2002) 177?184]
    NeuroToxicology, vol. 26, no. 2, pp. 295–295, 2005
  7. Acrylonitrile potentiates hearing loss and cochlear damage induced by moderate noise exposure in rats
    Toxicology and Applied Pharmacology, vol. 204, no. 1, pp. 46–56, 2005
  8. JP-8 jet fuel exposure induces inflammatory cytokines in rat skin
    International Immunopharmacology, vol. 4, no. 9, pp. 1159–1169, 2004
  9. Promotion of Noise-Induced Hearing Loss by Chemical Contaminants
    Journal of Toxicology and Environmental Health Part A, vol. 67, no. 8-10, pp. 727–740, 2004
  10. Acrylonitrile Potentiates Noise-Induced Hearing Loss in Rat
    JARO - Journal of the Association for Research in Otolaryngology, vol. 5, no. 1, pp. 90–98, 2004
  11. Acrylonitrile Produces Transient Cochlear Function Loss and Potentiates Permanent Noise-Induced Hearing Loss
    Toxicological Sciences, vol. 75, no. 1, pp. 117–123, 2003
  12. The relationship between noise-induced hearing loss and hair cell loss in rats
    Hearing Research, vol. 177, no. 1-2, pp. 81–90, 2003
  13. The Relationship of Particle Size to Olfactory Nerve Uptake of a Non-Soluble Form of Manganese Into Brain
    NeuroToxicology, vol. 23, no. 2, pp. 177–183, 2002
  14. Potentiation of Noise-Induced Hearing Loss by Low Concentrations of Hydrogen Cyanide in Rats
    Toxicological Sciences, vol. 66, no. 1, pp. 131–138, 2002
  15. Disruption of cochlear potentials by chemical asphyxiants Cyanide and carbon monoxide
    Neurotoxicology and Teratology, vol. 23, no. 2, pp. 157–165, 2001
  16. NMDA receptor blockage protects against permanent noise-induced hearing loss but not its potentiation by carbon monoxide
    Hearing Research, vol. 154, no. 1-2, pp. 108–115, 2001
  17. Free radical generation in the cochlea during combined exposure to noise and carbon monoxide: an electrophysiological and an EPR study
    Hearing Research, vol. 161, no. 1-2, pp. 113–122, 2001
  18. Succinate dehydrogenase (SDH) activity in hair cells: a correlate for permanent threshold elevations
    Hearing Research, vol. 145, no. 1-2, pp. 91–100, 2000
  19. Simultaneous monitoring of slow cell motility and calcium signals of the guinea pig outer hair cells
    Hearing Research, vol. 146, no. 1-2, pp. 121–133, 2000
  20. Increased noise severity limits potentiation of noise induced hearing loss by carbon monoxide
    Hearing Research, vol. 150, no. 1-2, pp. 206–214, 2000
  21. Characterization of the Ototoxicity of Difluoromethylornithine and Its Enantiomers
    Toxicological Sciences, vol. 56, no. 1, pp. 124–132, 2000
  22. Predicting Exposure Conditions that Facilitate the Potentiation of Noise-Induced Hearing Loss by Carbon Monoxide
    Toxicological Sciences, vol. 58, no. 2, pp. 315–323, 2000
  23. Low-Level Toluene Disrupts Auditory Function in Guinea Pigs
    Toxicology and Applied Pharmacology, vol. 167, no. 1, pp. 18–29, 2000
  24. Protective Effects of Phenyl-N-tert-butylnitrone on the Potentiation of Noise-Induced Hearing Loss by Carbon Monoxide
    Toxicology and Applied Pharmacology, vol. 167, no. 2, pp. 125–131, 2000
  25. Potentiation of octave-band noise induced auditory impairment by carbon monoxide
    Hearing Research, vol. 132, no. 1-2, pp. 149–159, 1999
  26. Intermittent noise-induced hearing loss and the influence of carbon monoxide
    Hearing Research, vol. 138, no. 1-2, pp. 181–191, 1999
  27. Corrigendum to ''Correspondence between middle frequency auditory loss in vivo and outer hair cell shortening in vitro'' [Hear. Res. 112 (1997) 134–140]
    Hearing Research, vol. 122, no. 1-2, p. 151, 1998
  28. Trichloroethylene Ototoxicity: Evidence for a Cochlear Origin,
    Toxicological Sciences, vol. 42, no. 1, pp. 28–35, 1998
  29. Cochlear Protection from Carbon Monoxide Exposure by Free Radical Blockers in the Guinea Pig
    Toxicology and Applied Pharmacology, vol. 142, no. 1, pp. 47–55, 1997
  30. Toluene Disrupts Outer Hair Cell Morphometry and Intracellular Calcium Homeostasis in Cochlear Cells of Guinea Pigs
    Toxicology and Applied Pharmacology, vol. 142, no. 2, pp. 270–277, 1997
  31. Correspondence between middle frequency auditory loss in vivo and outer hair cell shortening in vitro
    Hearing Research, vol. 112, no. 1-2, pp. 134–140, 1997
  32. Elevation of intracellular calcium levels in outer hair cells by trimethyltin
    Toxicology in Vitro, vol. 10, no. 5, pp. 567–571, 1996
  33. Performance of an Automatic Feedback Control Vapor Generation System during Near-Continuous Inhalation Exposures
    Inhalation Toxicology, vol. 8, no. 4, pp. 423–431, 1996
  34. Trimethyltin disrupts loudness recruitment and auditory threshold sensitivity in guinea pigs
    Neurotoxicology and Teratology, vol. 17, no. 3, pp. 281–287, 1995
  35. MK-801 Protects against Carbon Monoxide-Induced Hearing Loss
    Toxicology and Applied Pharmacology, vol. 132, no. 2, pp. 196–202, 1995
  36. Elevation of intracellular calcium levels in spiral ganglion cells by trimethyltin
    Hearing Research, vol. 91, no. 1-2, pp. 101–109, 1995
  37. Trimethyltin disrupts N1 sensitivity, but has limited effects on the summating potential and cochlear microphonic
    Hearing Research, vol. 78, no. 2, pp. 189–196, 1994
  38. In Vitro Organotin Administration Alters Guinea Pig Cochlear Outer Hair Cell Shape and Viability
    Toxicology and Applied Pharmacology, vol. 120, no. 2, pp. 193–202, 1993
  39. Effects of acute styrene and simultaneous noise exposure on auditory function in the guinea pig
    Neurotoxicology and Teratology, vol. 15, no. 3, pp. 151–155, 1993
  40. Rapid disruption of cochlear function and structure by trimethyltin in the guinea pig
    Hearing Research, vol. 58, no. 2, pp. 166–174, 1992
  41. Unusual morphology of the stria vascularis in pigmented strain 2/NCR guinea pigs
    Hearing Research, vol. 54, no. 1, pp. 39–44, 1991
  42. Trimethyltin disrupts auditory function and cochlear morphology in pigmented rats
    Neurotoxicology and Teratology, vol. 13, no. 2, pp. 135–145, 1991
  43. Effects of chronic carbon disulfide inhalation on sensory and motor function in the rat
    Neurotoxicology and Teratology, vol. 13, no. 3, pp. 249–255, 1991
  44. Acute ototoxicity of trialkyltins in the guinea pig
    Toxicology and Applied Pharmacology, vol. 109, no. 3, pp. 547–556, 1991
  45. Disruption of auditory function by acute administration of a ?room odorizer? containing butyl nitrite in rats
    Fundamental and Applied Toxicology, vol. 12, no. 1, pp. 56–61, 1989
  46. Potentiation of noise induced threshold shifts and hair cell loss by carbon monoxide
    Hearing Research, vol. 34, no. 1, pp. 39–47, 1988
  47. Brain regional manganese levels and monoamine metabolism in manganese-treated neonatal rats
    Neurotoxicology and Teratology, vol. 10, no. 4, pp. 295–303, 1988
  48. Sensory threshold estimation from a continuously graded response produced by reflex modification audiometry
    The Journal of the Acoustical Society of America, vol. 84, no. 1, p. 179, 1988
  49. Disruption of neostriatal development in rats following perinatal exposure to mild, but chronic carbon monoxide
    Neurotoxicology and Teratology, vol. 9, no. 4, pp. 277–281, 1987
  50. Trimethyltin ototoxicity in albino rats
    Neurotoxicology and Teratology, vol. 9, no. 5, pp. 329–332, 1987
  51. Effects of carbon monoxide on cochlear electrophysiology and blood flow
    Hearing Research, vol. 27, no. 1, pp. 37–45, 1987
  52. Carbon monoxide exposure potentiates high-frequency auditory threshold shifts induced by noise
    Hearing Research, vol. 26, no. 1, pp. 37–43, 1987
  53. Trimethyltin exposure produces an unusual form of toxic auditory damage in rats*1
    Toxicology and Applied Pharmacology, vol. 82, no. 1, pp. 87–93, 1986
  54. Trimethyltin ototoxicity: evidence for a cochlear site of injury
    Hearing Research, vol. 23, no. 3, pp. 275–282, 1986
  55. Postnatal Alterations in Cerebellar GABA Content, GABA Uptake and Morphology following Exposure to Carbon Monoxide Early in Development
    Developmental Neuroscience, vol. 8, no. 4, pp. 251–261, 1986
  56. Alteration in the Postnatal Ontogeny of Cerebellar Norepinephrine Content Following Chronic Prenatal Carbon Monoxide
    Journal of Neurochemistry, vol. 45, no. 3, pp. 965–969, 1985
  57. Moderate prenatal carbon monoxide exposure produces persistent, and apparently permanent, memory deficits in rats
    Teratology, vol. 31, no. 1, pp. 1–12, 1985
  58. Brain manganese, catecholamine turnover, and the development of startle in rats prenatally exposed to manganese
    Teratology, vol. 32, no. 1, pp. 1–11, 1985
  59. Prenatal carbon monoxide exposure differentially affects postnatal weight and monoamine concentration of rat brain regions
    Toxicology and Applied Pharmacology, vol. 81, no. 1, pp. 139–146, 1985
  60. Discrimination of auditory from nonauditory toxicity by reflex modulation audiometry: Effects of triethyltin*1
    Toxicology and Applied Pharmacology, vol. 70, no. 2, pp. 216–227, 1983
  61. Diethyldithiocarbamate depresses the acoustic startle response in rats
    Psychopharmacology, vol. 82, no. 1-2, pp. 68–72, 1983
  62. Reflex inhibition procedures for animal audiometry: A technique for assessing ototoxicity
    The Journal of the Acoustical Society of America, vol. 73, no. 5, p. 1686, 1983
  63. Effects of prenatal carbon monoxide exposure on cardiac development*1
    Toxicology and Applied Pharmacology, vol. 56, no. 3, pp. 370–375, 1980
  64. Evidence for catecholamine involvement in elaboration of the acoustic startle reaction in rats
    Brain Research, vol. 66, no. 2, pp. 370–370, 1974
  65. The effects of l-Dopa, clonidine, and apomorphine on the acoustic startle reaction in rats
    Psychopharmacologia, vol. 39, no. 4, pp. 331–344, 1974
  66. Central serotonin involvement in the elaboration of the startle reaction in rats
    Pharmacology Biochemistry and Behavior, vol. 2, no. 2, pp. 161–171, 1974
  67. The effects of p-chlorophenylalanine, a depletor of brain serotonin, on behavior: II. Retardation of passive avoidance learning
    Life Sciences, vol. 8, no. 8, pp. 379–385, 1969
  68. RELATIVE STRENGTHS OF APPROACH AND AVOIDANCE TENDENCIES IN DISCRIMINATION LEARNING OF RATS TRAINED UNDER TWO TYPES OF REINFORCEMENT.
    Journal of Experimental Psychology, vol. 76, no. 3, Pt.1, Article ID 1968-08651-001, 2 pages, 1968