Hengming Ke

Personal Home Page

http://www.med.unc.edu/biochem/ke.htm

Articles in Scholarly Journals [Incomplete List]

  1. From the Cover: Structural insight into substrate specificity of phosphodiesterase 10
    Proceedings of the National Academy of Sciences, vol. 104, no. 14, pp. 5782–5787, 2007
  2. The Molecular Basis for Different Recognition of Substrates by Phosphodiesterase Families 4 and 10
    Journal of Molecular Biology, vol. 371, no. 2, pp. 302–307, 2007
  3. Crystal Structures of Phosphodiesterases and Implications on Substrate Specificity and Inhibitor Selectivity
    Current Topics in Medicinal Chemistry, vol. 7, no. 4, pp. 391–403, 2007
  4. A 46-Amino Acid Segment in Phosphodiesterase-5 GAF-B Domain Provides for High Vardenafil Potency over Sildenafil and Tadalafil and Is Involved in Phosphodiesterase-5 Dimerization
    Molecular Pharmacology, vol. 70, no. 5, pp. 1822–1831, 2006
  5. Multiple Conformations of Phosphodiesterase-5: IMPLICATIONS FOR ENZYME FUNCTION AND DRUG DEVELOPMENT
    Journal of Biological Chemistry, vol. 281, no. 30, pp. 21469–21479, 2006
  6. Essential Role of the B23/NPM Core Domain in Regulating ARF Binding and B23 Stability
    Journal of Biological Chemistry, vol. 281, no. 27, pp. 18463–18472, 2006
  7. Journal of Medicinal Chemistry, vol. 49, no. 6, pp. 1867–1873, 2006
  8. Structures of the N-Terminal and Middle Domains of Hsp90 and Conformation Changes upon ADP Binding
    Structure, vol. 13, no. 4, pp. 579–590, 2005
  9. Multiple Elements Jointly Determine Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases 4 and 7
    Journal of Biological Chemistry, vol. 280, no. 35, pp. 30949–30955, 2005
  10. Crystal structures of cyclophilin and its partners
    Frontiers in Bioscience, vol. 9, no. 1-3, p. 2285, 2004
  11. Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-xL
    Experimental Cell Research, vol. 298, no. 2, pp. 329–338, 2004
  12. Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding
    Proceedings of the National Academy of Sciences, vol. 101, no. 26, pp. 9624–9629, 2004
  13. Implications of PDE4 structure on inhibitor selectivity across PDE families
    International Journal of Impotence Research, vol. 16, Article ID 3901211, 2004
  14. Three-Dimensional Structures of PDE4D in Complex with Roliprams and Implication on Inhibitor Selectivity
    Structure, vol. 11, no. 7, pp. 865–873, 2003
  15. Crystal structure of DJ-1/RS and implication on familial Parkinson's disease
    FEBS Letters, vol. 549, no. 1-3, pp. 171–175, 2003
  16. Lats2, a putative tumor suppressor, inhibits G1/S transition
    Oncogene, vol. 22, no. 28, Article ID 1206603, 7 pages, 2003
  17. Crystal Structures of Phosphodiesterases 4 and 5 in Complex with Inhibitor 3-Isobutyl-1-methylxanthine Suggest a Conformation Determinant of Inhibitor Selectivity
    Journal of Biological Chemistry, vol. 279, no. 13, pp. 13095–13101, 2003
  18. Biochemistry, vol. 42, no. 45, pp. 13220–13226, 2003
  19. Familial Parkinson's Disease-associated L166P Mutation Disrupts DJ-1 Protein Folding and Function
    Journal of Biological Chemistry, vol. 279, no. 9, pp. 8506–8515, 2003
  20. Structures of calcineurin and its complexes with immunophilins–immunosuppressants
    Biochemical and Biophysical Research Communications, vol. 311, no. 4, pp. 1095–1102, 2003
  21. Identification of Interaction Sites of Cyclic Nucleotide Phosphodiesterase Type 3A with Milrinone and Cilostazol Using Molecular Modeling and Site-Directed Mutagenesis
    Molecular Pharmacology, vol. 62, no. 3, pp. 514–520, 2002
  22. Molecular Docking of Competitive Phosphodiesterase Inhibitors
    Molecular Pharmacology, vol. 61, no. 1, pp. 20–25, 2002
  23. Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
    Proceedings of the National Academy of Sciences, vol. 99, no. 19, pp. 12037–12042, 2002
  24. Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans
    Molecular Microbiology, vol. 39, no. 4, pp. 835–849, 2001
  25. Nature Structural Biology, vol. 8, no. 8, pp. 665–669, 2001
  26. Identification of overlapping but distinct cAMP and cGMP interaction sites with cyclic nucleotide phosphodiesterase 3A by site-directed mutagenesis and molecular modeling based on crystalline PDE4B
    Protein Science, vol. 10, no. 8, pp. 1481–1489, 2001
  27. Crystal structure of NaeI--an evolutionary bridge between DNA endonuclease and topoisomerase
    The EMBO Journal, vol. 19, no. 12, pp. 3110–3118, 2000
  28. Atomic Structure of PDE4: Insights into Phosphodiesterase Mechanism and Specificity
    Science, vol. 288, no. 5472, pp. 1822–1825, 2000
  29. Cyclophilin A complexed with a fragment of HIV-1 gag protein: insights into HIV-1 infectious activity
    Structure, vol. 5, no. 1, pp. 139–146, 1997
  30. Biochemistry, vol. 35, no. 23, pp. 7362–7368, 1996
  31. Biochemistry, vol. 35, no. 23, pp. 7356–7361, 1996
  32. Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-6(E)-2-butenyl9-4,4-dimethylthreonine cyclosporin A
    Structure, vol. 2, no. 1, pp. 33–44, 1994
  33. The Monofunctional Chorismate Mutase from Bacillus subtilisStructure Determination of Chorismate Mutase and Its Complexes with a Transition State Analog and Prephenate, and Implications for the Mechanism of the Enzymatic Reaction
    Journal of Molecular Biology, vol. 240, no. 5, pp. 476–500, 1994
  34. Crystal Structure of Murine Cyclophilin C Complexed with Immunosuppressive Drug Cyclosporin A
    Proceedings of the National Academy of Sciences, vol. 90, no. 24, pp. 11850–11854, 1993
  35. Crystal Structure of Cyclophilin A Complexed with Substrate Ala-Pro Suggests a Solvent-Assisted Mechanism of Cis-Trans Isomerization
    Proceedings of the National Academy of Sciences, vol. 90, no. 8, pp. 3324–3328, 1993
  36. Crystal Structures of the Monofunctional Chorismate Mutase from Bacillus subtilis and its Complex with a Transition State Analog
    Proceedings of the National Academy of Sciences, vol. 90, no. 18, pp. 8600–8603, 1993
  37. Biochemistry, vol. 32, no. 7, pp. 1844–1857, 1993
  38. Similarities and differences between human cyclophilin A and other ?-barrel structures Structural refinement at 1.63 p resolution
    Journal of Molecular Biology, vol. 228, no. 2, pp. 539–550, 1992
  39. Crystal Structure of the Neutral Form of Fructose 1,6,-Bisphosphatase Complexed with Regulatory Inhibitor Fructose 2,6-Bisphosphate at 2.6- A
    Proceedings of the National Academy of Sciences, vol. 89, no. 6, pp. 2404–2408, 1992
  40. Crystal Structure of the Neutral Form of Fructose-1,6-Bisphosphatase Complexed with the Product Fructose 6-Phosphate at 2.1- A Resolution
    Proceedings of the National Academy of Sciences, vol. 88, no. 8, pp. 2989–2993, 1991
  41. Biochemistry, vol. 30, no. 18, pp. 4412–4420, 1991
  42. Crystal Structure of Recombinant Human T-Cell Cyclophilin A at 2.5 A Resolution
    Proceedings of the National Academy of Sciences, vol. 88, no. 21, pp. 9483–9487, 1991
  43. Crystal Structure of Fructose-1,6-Bisphosphatase Complexed with Fructose 6-Phosphate, AMP, and Magnesium
    Proceedings of the National Academy of Sciences, vol. 87, no. 14, pp. 5243–5247, 1990
  44. Structure refinement of fructose-1,6-bisphosphatase and its fructose 2,6-bisphosphate complex at 2.8 p resolution Hengming Ke, Cheleste M. Thorpe, Barbara A. Seaton, William N. Lipscomb, Frank Marcus J. Mol. Biol. (1990) 2112, 513–539
    Journal of Molecular Biology, vol. 214, no. 4, p. 950, 1990
  45. Structure refinement of fructose-1,6-bisphosphatase and its fructose 2,6-bisphosphate complex at 2.8 p resolution
    Journal of Molecular Biology, vol. 212, no. 3, pp. 513–539, 1990
  46. Molecular Structure of Fructose-1,6-bisphosphatase at 2.8- angstrom Resolution
    Proceedings of the National Academy of Sciences, vol. 86, no. 5, pp. 1475–1479, 1989
  47. Crystal Structure of the Glu-239 rightarrow Gln Mutant of Aspartate Carbamoyltransferase at 3.1-A Resolution: An Intermediate Quaternary Structure
    Proceedings of the National Academy of Sciences, vol. 86, no. 21, pp. 8212–8216, 1989
  48. Complex of N-phosphonacetyl--aspartate with aspartate carbamoyltransferase X-ray refinement, analysis of conformational changes and catalytic and allosteric mechanisms
    Journal of Molecular Biology, vol. 204, no. 3, pp. 725–747, 1988
  49. Structural asymmetry in the CTP-liganded form of aspartate carbamoyltransferase from
    Journal of Molecular Biology, vol. 196, no. 4, pp. 853–875, 1987
  50. Structure of Unligated Aspartate Carbamoyltransferase of Escherichia coli at 2.6- angstrom Resolution
    Proceedings of the National Academy of Sciences, vol. 81, no. 13, pp. 4037–4040, 1984
  51. Gross Quaternary Changes in Aspartate Carbamoyltransferase are Induced by the Binding of N-(phosphonacetyl)-L-aspartate: A 3.5- angstrom Resolution Study
    Proceedings of the National Academy of Sciences, vol. 79, no. 10, pp. 3125–3128, 1982