I am an Assistant Professor in the Department of Biochemistry and the Director of the Multiphoton Imaging Facility at Weill Medical College of Cornell University (WCMC). My graduate (PhD) work at the Centre for Cellular and Molecular Biology, India, consisted of steady state and time resolved fluorescence spectroscopy in model membranes, which I extended to advanced optical microscopy (including wide-field and confocal fluorescence microscopy) to study intracellular trafficking in tissue culture cells during my postdoctoral research at the Columbia and Cornell University Medical colleges. I have further enhanced my abilities to meaningfully contribute to clinical and translational research by earning, in 2010, a Master of Science degree in Clinical Investigation from WCMC. As the Director of the Multiphoton Imaging facility at WCMC over the past four years, I have combined this scientific expertise along with my ability to form effective collaborations with researchers from various specialties, to create a thriving project with the overall goal of developing and validating a variety of “optical biopsy” techniques to potentially assist in intra-surgical decision-making. Our laboratory concentrates on two optical imaging approaches, namely multiphoton microscopy and full field optical coherence tomography, both of which can generate high-resolution three-dimensional image sets from fresh (unprocessed and unstained) human and animal tissues. The ultimate goal of optical biopsies is to enable “interventional pathology,” where a surgeon and/or a pathologist will have access to detailed histological information about the tissue during a surgery or an endoscopy, without the need to excise the tissue or to administer any exogenous contrast agent. This information, in turn, will likely allow them to make more informed decisions about resection margins, features to be biopsied or not, and sparing sensitive structures in the surgical field (e.g., critical nerves).
Biography Updated on 1 March 2012