Andrew D. Hollenbach0000-0003-2044-8737
Andrew D. Hollenbach received his Ph.D. degree from Johns Hopkins University, Baltimore, Md, USA, in 1994, and conducted his postdoctoral training in the Laboratory of Dr. Gerard Grosveld at St. Jude Children’s Research Hospital, Memphis, Tenn, USA. He accepted a position in the Department of Genetics at Louisiana State University Health Sciences Center, Shreveport, La, USA, in April 2003 where he presently serves as an Associate Professor. His research focuses on understanding how phosphorylation of the transcription factor Pax3 regulates its biological activity to control muscle development and how alteration of this activity contributes to the development of the childhood solid muscle tumor alveolar rhabdomyosarcoma (ARMS) and melanoma. Towards this end, his lab has identified the three sites of phosphorylation on Pax3; they have identified the kinases responsible for phosphorylating these sites, and they have determined that the pattern of Pax3 phosphorylation changes significantly during the first eight hours of myogenesis. They also focus on the oncogenic fusion protein, Pax3-FOXO1, which results from the characteristic t(2;13) reciprocal chromosomal translocation, the hallmark of ARMS. His lab has determined that the pattern of phosphorylation on Pax3-FOXO1 is significantly different from wild-type Pax3. Dr. Hollenbach is interested in elucidating how the altered phosphorylation of Pax3-FOXO1 changes the normal functions of wild-type Pax3 to contribute to the development of ARMS. A second project involves examining how phosphorylation of Pax3 contributes to melanoma development. In addition to having increased levels of Pax3, Dr. Hollenbach’s lab has discovered that Pax3 has an altered pattern of phosphorylation in a metastatic melanoma cell line relative to wild-type melanocytes. His lab is interested in elucidating how this altered phosphorylation affects normal Pax3 regulation to promote melanoma cell survival.
Biography Updated on 17 October 2013