Toshiyasu Sasaoka

Articles in Scholarly Journals [Incomplete List]

  1. Telmisartan reduced blood pressure and HOMA-IR with increasing plasma leptin level in hypertensive and type 2 diabetic patients
    Diabetes Research and Clinical Practice, vol. 77, no. 2, pp. 210–214, 2007
  2. Coenzyme Q10 prevents high glucose-induced oxidative stress in human umbilical vein endothelial cells
    European Journal of Pharmacology, vol. 566, no. 1-3, pp. 1–10, 2007
  3. Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity
    Pharmacology & Therapeutics, vol. 112, no. 3, pp. 799–809, 2006
  4. Novel G423S Mutation of Human  7 Nicotinic Receptor Promotes Agonist-Induced Desensitization by a Protein Kinase C-Dependent Mechanism
    Molecular Pharmacology, vol. 71, no. 3, pp. 777–786, 2006
  5. Chronic Nicotine Exposure Enhances Insulin-Induced Mitogenic Signaling via Up-Regulation of  7 Nicotinic Receptors in Isolated Rat Aortic Smooth Muscle Cells
    Endocrinology, vol. 148, no. 2, pp. 790–799, 2006
  6. Impact of Src Homology 2-Containing Inositol 5'-Phosphatase 2 Gene Polymorphisms Detected in a Japanese Population on Insulin Signaling
    Journal of Clinical Endocrinology & Metabolism, vol. 90, no. 5, pp. 2911–2919, 2005
  7. Interleukin-1  Inhibits Insulin Signaling with Phosphorylating Insulin Receptor Substrate-1 on Serine Residues in 3T3-L1 Adipocytes
    Molecular Endocrinology, vol. 20, no. 1, pp. 114–124, 2005
  8. Marine Alkaloids (−)-Pictamine and (−)-Lepadin B Block Neuronal Nicotinic Acetylcholine Receptors
    Biological & Pharmaceutical Bulletin, vol. 28, no. 4, pp. 611–614, 2005
  9. Altered Subcellular Distribution of Estrogen Receptor   Is Implicated in Estradiol-Induced Dual Regulation of Insulin Signaling in 3T3-L1 Adipocytes
    Endocrinology, vol. 147, no. 2, pp. 1020–1028, 2005
  10. Impact of the Liver-Specific Expression of SHIP2 (SH2-Containing Inositol 5'-Phosphatase 2) on Insulin Signaling and Glucose Metabolism in Mice
    Diabetes, vol. 54, no. 7, pp. 1958–1967, 2005
  11. Antiangiogenic activity of ?-eudesmol in vitro and in vivo
    European Journal of Pharmacology, vol. 512, no. 2-3, pp. 105–115, 2005
  12. Inhibition of endogenous SHIP2 ameliorates insulin resistance caused by chronic insulin treatment in 3T3-L1 adipocytes
    Diabetologia, vol. 48, no. 2, pp. 336–344, 2005
  13. SH2-containing Inositol Phosphatase 2 Predominantly Regulates Akt2, and Not Akt1, Phosphorylation at the Plasma Membrane in Response to Insulin in 3T3-L1 Adipocytes
    Journal of Biological Chemistry, vol. 279, no. 15, pp. 14835–14843, 2004
  14. Deletion of the PDGFR-  Gene Affects Key Fibroblast Functions Important for Wound Healing
    Journal of Biological Chemistry, vol. 280, no. 10, pp. 9375–9389, 2004
  15. Alkaloids Indolizidine 235B', Quinolizidine 1-epi-207I, and the Tricyclic 205B are Potent and Selective Noncompetitive Inhibitors of Nicotinic Acetylcholine Receptors
    Molecular Pharmacology, vol. 66, no. 4, pp. 1061–1069, 2004
  16. Nicotinic Enhancement of Proliferation in Bovine and Porcine Cerebral Microvascular Endothelial Cells
    Biological & Pharmaceutical Bulletin, vol. 27, no. 12, pp. 1951–1956, 2004
  17. Impact of Src Homology 2-Containing Inositol 5'-Phosphatase 2 on the Regulation of Insulin Signaling Leading to Protein Synthesis in 3T3-L1 Adipocytes Cultured with Excess Amino Acids
    Endocrinology, vol. 145, no. 7, pp. 3215–3223, 2004
  18. BMC Pharmacology, vol. 4, no. 1, p. 18, 2004
  19. Dual Role of Src Homology Domain 2-Containing Inositol Phosphatase 2 in the Regulation of Platelet-Derived Growth Factor and Insulin-Like Growth Factor I Signaling in Rat Vascular Smooth Muscle Cells
    Endocrinology, vol. 144, no. 9, pp. 4204–4214, 2003
  20. Association of the polymorphisms in the 5'-untranslated region of PTEN gene with type 2 diabetes in a Japanese population
    FEBS Letters, vol. 554, no. 3, pp. 450–454, 2003
  21. Active Src expression is induced after rat peripheral nerve injury
    Glia, vol. 42, no. 2, pp. 184–193, 2003
  22. Reduction of blood glucose level by orexins in fasting normal and streptozotocin-diabetic mice
    European Journal of Pharmacology, vol. 448, no. 2-3, pp. 245–252, 2002
  23. Membrane Localization of Src Homology 2-Containing Inositol 5'-Phosphatase 2 via Shc Association Is Required for the Negative Regulation of Insulin Signaling in Rat1 Fibroblasts Overexpressing Insulin Receptors
    Molecular Endocrinology, vol. 16, no. 10, pp. 2371–2381, 2002
  24. Association of SH2-Containing Inositol Phosphatase 2 With the Insulin Resistance of Diabetic db/db Mice
    Diabetes, vol. 51, no. 8, pp. 2387–2394, 2002
  25. Effects of Pimobendan on Adverse Cardiac Events and Physical Activities in Patients With Mild to Moderate Chronic Heart Failure
    Circulation Journal, vol. 66, no. 2, pp. 149–149, 2002
  26. Pioglitazone Ameliorates Tumor Necrosis Factor- -Induced Insulin Resistance by a Mechanism Independent of Adipogenic Activity of Peroxisome Proliferator-Activated Receptor- 
    Diabetes, vol. 50, no. 5, pp. 1083–1092, 2001
  27. Growth Hormone Induces Cellular Insulin Resistance by Uncoupling Phosphatidylinositol 3-Kinase and Its Downstream Signals in 3T3-L1 Adipocytes
    Diabetes, vol. 50, no. 8, pp. 1891–1900, 2001
  28. Tyrosine Phosphorylation-Dependent and -Independent Role of Shc in the Regulation of IGF-1-Induced Mitogenesis and Glycogen Synthesis
    Endocrinology, vol. 142, no. 12, pp. 5226–5235, 2001
  29. Overexpression of SH2-Containing Inositol Phosphatase 2 Results in Negative Regulation of Insulin-Induced Metabolic Actions in 3T3-L1 Adipocytes via Its 5'-Phosphatase Catalytic Activity
    Molecular and Cellular Biology, vol. 21, no. 5, pp. 1633–1646, 2001
  30. Potential Role of Gab1 and Phospholipase C-? in Osmotic Shock-Induced Glucose Uptake in 3T3-L1 Adipocytes
    Hormone and Metabolic Research, vol. 33, no. 7, pp. 402–406, 2001
  31. Glucosamine enhances platelet-derived growth factor-induced DNA synthesis via phosphatidylinositol 3-kinase pathway in rat aortic smooth muscle cells
    Atherosclerosis, vol. 157, no. 2, pp. 341–352, 2001
  32. SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes
    Diabetologia, vol. 44, no. 10, pp. 1258–1267, 2001
  33. Retinoblastoma Protein Phosphorylation via PI 3-Kinase and mTOR Pathway Regulates Adipocyte Differentiation
    Biochemical and Biophysical Research Communications, vol. 275, no. 1, pp. 115–120, 2000
  34. Molecular Cloning of Rat SH2-Containing Inositol Phosphatase 2 (SHIP2) and Its Role in the Regulation of Insulin Signaling
    Biochemical and Biophysical Research Communications, vol. 260, no. 1, pp. 265–272, 1999
  35. Intracellular Signalling Pathways of Okadaic Acid Leading to Mitogenesis in Rat1 Fibroblast Overexpressing Insulin Receptors Okadaic Acid Regulates Shc Phosphorylation by Mechanisms Independent of Insulin
    Cellular Signalling, vol. 11, no. 11, pp. 797–803, 1999
  36. Role of the Src Homology 2 (SH2) Domain and C-Terminus Tyrosine Phosphorylation Sites of SH2-Containing Inositol Phosphatase (SHIP) in the Regulation of Insulin-Induced Mitogenesis
    Endocrinology, vol. 140, no. 10, pp. 4585–4594, 1999
  37. Synergistic Role of the Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase Cascade in the Regulation of Insulin Receptor Trafficking
    Endocrinology, vol. 140, no. 8, pp. 3826–3834, 1999
  38. Involvement of Heat Shock Protein 90 in the Degradation of Mutant Insulin Receptors by the Proteasome
    Journal of Biological Chemistry, vol. 273, no. 18, pp. 11183–11188, 1998
  39. Relative Involvement of Shc Tyrosine 239/240 and Tyrosine 317 on Insulin Induced Mitogenic Signaling in Rat1 Fibroblasts Expressing Insulin Receptors
    Biochemical and Biophysical Research Communications, vol. 252, no. 1, pp. 139–144, 1998
  40. Functional Importance of Heat Shock Protein 90 Associated with Insulin Receptor on Insulin-Stimulated Mitogenesis
    Biochemical and Biophysical Research Communications, vol. 237, no. 2, pp. 345–347, 1997
  41. Fatty acid induced insulin resistance in rat-1 fibroblasts overexpressing human insulin receptors: impaired insulin-stimulated mitogen-activated protein kinase activity
    Diabetologia, vol. 40, no. 8, pp. 894–901, 1997
  42. Functional Importance of Shc Tyrosine 317on Insulin Signaling in Rat1 Fibroblasts Expressing Insulin Receptors
    Journal of Biological Chemistry, vol. 272, no. 14, pp. 9581–9586, 1997
  43. Involvement of ErbB2 in the Signaling Pathway Leading to Cell Cycle Progression from a Truncated Epidermal Growth Factor Receptor Lacking the C-terminal Autophosphorylation Sites
    Journal of Biological Chemistry, vol. 271, no. 14, pp. 8338–8344, 1996
  44. Functional Importance of Amino-terminal Domain of Shc for Interaction with Insulin and Epidermal Growth Factor Receptors in Phosphorylation-independent Manner
    Journal of Biological Chemistry, vol. 271, no. 33, pp. 20082–20087, 1996
  45. The dominant negative effect of a kinase-defective insulin receptor on insulin-like growth factor-I-stimulated signaling in Rat-1 fibroblasts*1
    Metabolism, vol. 45, no. 12, pp. 1474–1482, 1996
  46. Hsp70 Family Molecular Chaperones and Mutant Insulin Receptor: Differential Binding Specificities of BiP and Hsp70/Hsc70 Determines Accumulation or Degradation of Insulin Receptor
    Biochemical and Biophysical Research Communications, vol. 218, no. 2, pp. 449–453, 1996
  47. Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways
    Endocrinology, vol. 137, no. 10, pp. 4427–4434, 1996
  48. Functional characterization of hybrid receptors composed of a truncated insulin receptor and wild type insulin-like growth factor 1 or insulin receptors
    Endocrinology, vol. 136, no. 5, pp. 1978–1986, 1995
  49. Mechanisms of Enhanced Transmembrane Signaling by an Insulin Receptor Lacking a Cytoplasmic [IMAGE]-Subunit Domain
    Journal of Biological Chemistry, vol. 270, no. 18, pp. 10885–10892, 1995
  50. Insulin Stimulates the Tyrosine Dephosphorylation of pp125 Focal Adhesion Kinase
    Journal of Biological Chemistry, vol. 270, no. 3, pp. 991–994, 1995
  51. Negative Feedback Regulation and Desensitization of Insulin- and Epidermal Growth Factor-stimulated p21[IMAGE] Activation
    Journal of Biological Chemistry, vol. 270, no. 43, pp. 25320–25323, 1995
  52. Insulin and epidermal growth factor influence guanine nucleotide- releasing factor by distinct mechanisms
    Endocrinology, vol. 135, no. 6, pp. 2412–2417, 1994
  53. A truncated human insulin receptor missing the COOH-terminal 365 amino acid residues does not undergo insulin-mediated receptor migration or aggregation
    Endocrinology, vol. 132, no. 4, pp. 1453–1462, 1993
  54. Transmembrane Signaling by an Insulin Receptor Lacking a Cytoplasmic  -Subunit Domain
    Proceedings of the National Academy of Sciences, vol. 90, no. 10, pp. 4379–4383, 1993
  55. A mutation (Trp1193?Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance
    Diabetologia, vol. 36, no. 5, pp. 414–422, 1993
  56. Binding specificity and intramolecular signal transmission of uncleaved insulin proreceptor in transformed lymphocytes from a patient with extreme insulin resistance
    Diabetologia, vol. 32, no. 6, pp. 371–377, 1989
  57. Unprocessed insulin proreceptor in cultured fibroblasts from a patient with extreme insulin resistance
    Metabolism, vol. 38, no. 10, pp. 990–996, 1989
  58. Receptor binding and biologic activity of biosynthetic human insulin and mini-proinsulin produced by recombinant gene technology
    Diabetes Research and Clinical Practice, vol. 7, no. 1, pp. 25–28, 1989
  59. Unprocessed insulin proreceptors due to point mutation at the cleavage site
    Diabetes Research and Clinical Practice, vol. 7, pp. S35–S39, 1989
  60. W-7 specifically inhibits insulin-induced increase in glucose transport
    Diabetes Research and Clinical Practice, vol. 6, no. 2, pp. 109–113, 1989
  61. Insulin resistance by unprocessed insulin proreceptors point mutation at the cleavage site
    Biochemical and Biophysical Research Communications, vol. 153, no. 2, pp. 657–663, 1988