Richard Aspinall

Richard Aspinall received his B.S. degree in microbiology from Bristol University, and his Ph.D. degree on the development of the immune system from Birmingham University. On completion he taught anatomy for a year and then moved to Oxford University. From there he moved to the position of Senior Scientific Officer at the Institute of Animal Physiology in Cambridge where he worked on immunological tolerance. Whilst there he was asked to help start a biotechnology company which he joined, and stayed for four years. He then returned to academia in the mid 1990s and is now in the Faculty of Medicine at Imperial College London where he works on a therapeutic approach to age associated immune deficiencies. He is a Member of the British Society for Immunology, the British Transplantation Society, the British Society for Research on Ageing, and is now a Member of MRC College of Experts. In addition he has served on the editorial boards of the journals “Mechanisms of Ageing and Development” and also “Biogerontology”, is a Section Editor on “Immunity and Ageing” and until recently was Chairman of the British Society for Research on Ageing.

Biography Updated on 9 May 2007

Articles in Scholarly Journals [Incomplete List]

  1. T cell development, ageing and Interleukin-7
    Mechanisms of Ageing and Development, vol. 127, no. 6, pp. 572–578, 2006
  2. Cancer, aging and the immune system
    Aging Health, vol. 2, no. 2, pp. 229–239, 2006
  3. Interleukin-7: An Interleukin for Rejuvenating the Immune System
    Annals of the New York Academy of Sciences, vol. 1019, no. 1, pp. 116–122, 2004
  4. Evidence of thymic reconstitution after highly active antiretroviral therapy in HIV-1 infection
    HIV Medicine, vol. 5, no. 2, pp. 67–73, 2004
  5. Reversal of thymic atrophy
    Experimental Gerontology, vol. 39, no. 4, pp. 673–678, 2004
  6. Age-related changes in the function of T cells
    Microscopy Research and Technique, vol. 62, no. 6, pp. 508–513, 2003
  7. Intracellular Adhesion Molecule 1 Plays a Key Role in Acquired Immunity to Salmonellosis
    Infection and Immunity, vol. 71, no. 10, pp. 5881–5891, 2003
  8. Thymic Output during Initial Highly Active Antiretroviral Therapy (HAART) and during HAART Supplementation with Interleukin 2 and/or with HIV Type 1 Immunogen (Remune)
    AIDS Research and Human Retroviruses, vol. 19, no. 2, pp. 103–109, 2003
  9. My T's gone cold, I'm wondering why...
    Nature Immunology, vol. 4, no. 3, Article ID ni0303-203, 2 pages, 2003
  10. Effect of CD4+ and CD8+ cell depletion on wound healing
    British Journal of Surgery, vol. 88, no. 2, pp. 298–304, 2002
  11. Thymic activity in late-stage HIV-1 infected individuals receiving highly active antiretroviral therapy: potential effect of steroid therapy
    HIV Medicine, vol. 3, no. 1, pp. 56–61, 2002
  12. Molecular quantitation of thymic output in mice and the effect of IL-7
    European Journal of Immunology, vol. 32, no. 10, pp. 2827–2836, 2002
  13. Age-associated changes in thymopoiesis
    Springer Seminars in Immunopathology, vol. 24, no. 1, pp. 87–101, 2002
  14. Age-associated thymic atrophy is linked to a decline in IL-7 production
    Experimental Gerontology, vol. 37, no. 2-3, pp. 455–463, 2002
  15. A simple method for the measurement of sjTREC levels in blood
    Mechanisms of Ageing and Development, vol. 121, no. 1-3, pp. 59–67, 2001
  16. Age-Associated Thymic Atrophy Is Not Associated with a Deficiency in the CD44+CD25-CD3-CD4-CD8- Thymocyte Population
    Cellular Immunology, vol. 212, no. 2, pp. 150–157, 2001
  17. Both age and gender affect thymic output: more recent thymic migrants in females than males as they age
    Clinical and Experimental Immunology, vol. 125, no. 3, pp. 409–413, 2001
  18. Thymic atrophy in the mouse is a soluble problem of the thymic environment
    Vaccine, vol. 18, no. 16, pp. 1629–1637, 2000
  19. Erythrocyte Transfusion Causes Immunosuppression After Total Hip Replacement
    Clinical Orthopaedics and Related Research, vol. 381, pp. 145–155, 2000
  20. ROLE OF THE THYMUS IN T LYMPHOCYTE RECONSTITUTION
    Transplantation, vol. 69, no. 11, pp. 2238–2239, 2000
  21. Journal of Clinical Immunology, vol. 20, no. 4, pp. 250–256, 2000
  22. Production of human allotype-specific anti-CD45 monoclonal antibodies
    Immunology Letters, vol. 68, no. 2-3, pp. 333–337, 1999
  23. Does the immune system of a mouse age faster than the immune system of a human?
    BioEssays, vol. 21, no. 6, pp. 519–524, 1999
  24. Age-related changes in the absolute number of CD95 positive cells in T cell subsets in the blood
    Experimental Gerontology, vol. 33, no. 6, pp. 581–591, 1998
  25. Prolonged survival of skin grafts following treatment with an antibody to a putative cell triggering molecule, QCA-1
    European Journal of Immunology, vol. 21, no. 12, pp. 3053–3056, 1991
  26. Invariant involvement of IL-2 in thymocyte differentiation
    Immunology Today, vol. 12, no. 7, p. 246, 1991
  27. T-cell development in the fetus and the invariant series hypothesis
    Immunology Today, vol. 12, no. 1, pp. 7–10, 1991
  28. Increased yields of IL-2 in media conditioned by MLA 144 cells
    Journal of Immunological Methods, vol. 101, no. 1, pp. 79–84, 1987
  29. Lymphocyte differentiation and major histocompatibility complex antigen expression in the embryonic thymus
    Nature, vol. 284, no. 5752, Article ID 284177a0, 2 pages, 1980