Metal-Based Drugs
Volume 7 (2000), Issue 5, Pages 271-274
http://dx.doi.org/10.1155/MBD.2000.271

Effects of Organoantimony(III) Compounds of Sterically Hindered Bifunctional Tetradentate Ligands on the Reproductive System of Male Rats

1Department of Chemistry, University of Rajasthan, Jaipur 302 004, India
2Department of Zoology, University of Rajasthan, Jaipur 302 004, India

Received 13 December 2000; Accepted 19 January 2001

Copyright © 2000 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The antifertility activity of organoantimony(III) complexes PhSb[RC(NC6H4S)CH2(NC6H4S)CR′] {R' = CH3 (R1) and R = R' = CF3 (R2)} derived from corresponding sterically hinlered bifuinctional tetradentate ligands in the male rats was determined. The administration of compounds R1 and R2 at the dose level of 20 mg/kg. b. wt. siignificantly reduced the weights of testes and epididymides. Auxiliary glands showed a significant reduction after the treatment of compound R1 only. Treated animals showed a notable depression of spermatogenesis. The preleptotene spermatocytes were decreased by 76.19 and 47.06; the secondary spermatocytes by 87.4% and 54.87337; and the step-19 spermatids by 72.9 and 46.77% respectively, following the compound R1 and R2 treatment. Reduced sperm count and motility resulted in 100% negative fertility in both the treated groups. A significant fall in the content of various biochemical parameters of eproductive tissues was observed after R1 and R2 treatment in comparison to controls.