Scholarly Research Exchange
Volume 2008 (2008), Article ID 434329, 5 pages
doi:10.3814/2008/434329
Research Article
New Approach for the Synthesis of Pyrido[1,2-a]pyrimidines
Organic Chemistry Research Center, Department of Chemistry, KTHM College, Gangapur Road, Nashik 422002, India
Received 1 March 2008; Accepted 13 August 2008
Copyright © 2008 Raghunath B. Toche et al. This is an open access article distributed under the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- N. Hossain, J. Rozenski, E. De Clercq, and P. Herdewijn, “Synthesis and antiviral activity of the -analogues of 1,5-anhydrohexitol nucleosides (1,5-anhydro-2,3-dideoxy-D-ribohexitol nucleosides),” Journal of Organic Chemistry, vol. 62, no. 8, pp. 2442–2447, 1997.
- R. W. Sabnis and D. W. Rangnekar, “Synthesis of thieno[2,3-d]pyrimidine derivatives and their
fluorescent and biological properties,” Indian Journal of Technology, vol. 28, no. 2, pp. 54–58, 1990.
- S. Joseph and J. M. Burke, “Optimization of an anti-HIV hairpin ribozyme by in vitro selection,” The Journal of Biological Chemistry, vol. 268, no. 33, pp. 24515–24518, 1993.
- B. C. Bookser, B. G. Ugarkar, M. C. Matelich, et al., “Adenosine kinase inhibitors. 6. Synthesis, water solubility, and antinociceptive activity of 5-phenyl-7-(5-deoxy--d-ribofuranosyl) pyrrolo[2,3-d]pyrimidines substituted at C4 with glycinamides and related compounds,” Journal of Medicinal Chemistry, vol. 48, no. 24, pp. 7808–7820, 2005. View at Publisher · View at Google Scholar · View at PubMed
- P. G. Baraldi, B. Cacciari, R. Romagnoli, et al., “7-substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: a study on the importance of modifications at the side chain on the activity and solubility,” Journal of Medicinal Chemistry, vol. 45, no. 1, pp. 115–126, 2002. View at Publisher · View at Google Scholar
- S. C. Goodacre, L. J. Street, D. J. Hallett, et al., “Imidazo[1,2-]pyrimidines as functionally selective and orally bioavailable 2/3 binding site agonists for the treatment of anxiety disorders,” Journal of Medicinal Chemistry, vol. 49, no. 1, pp. 35–38, 2006. View at Publisher · View at Google Scholar · View at PubMed
- C. Chen, K. M. Wilcoxen, C. Q. Huang, et al., “Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylamino-pyrazolo[1,5-]pyrimidine (NBI 30775/R121919) and structure-activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists,” Journal of Medicinal Chemistry, vol. 47, no. 19, pp. 4787–4798, 2004. View at Publisher · View at Google Scholar · View at PubMed
- S. Wang, A. Folkes, I. Chuckowree, et al., “Studies on pyrrolopyrimidines as selective Inhibitors of multidrug-resistance-associated protein in multidrug resistance,” Journal of Medicinal Chemistry, vol. 47, no. 6, pp. 1329–1338, 2004. View at Publisher · View at Google Scholar · View at PubMed
- A. Gangjee, H. D. Jain, J. Phan, et al., “Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates,” Journal of Medicinal Chemistry, vol. 49, no. 3, pp. 1055–1065, 2006. View at Publisher · View at Google Scholar · View at PubMed
- O. Bruno, C. Brullo, S. Schenone, et al., “Synthesis, antiplatelet and antithrombotic activities of new 2-substituted benzopyrano[4,3-d]pyrimidin-4-cycloamines and 4-amino/cycloamino-benzopyrano[4, 3-d]pyrimidin-5-ones,” Bioorganic & Medicinal Chemistry, vol. 14, no. 1, pp. 121–130, 2006. View at Publisher · View at Google Scholar · View at PubMed
- G. La Vielle, T. Dubuffet, O. Muller, M. Millan, A. Dekeyne, and M. Brocco, “Preparation of pyrimidin-4-one derivatives, their pharmaceutical compositions and use as 2/5-HT2c double antagonists,” (Les Laboratories Servier, France) FR 2823752 Al20021025, 2002.
- R. T. Venkatasubramanian, D. G. Sathe, D. Govind, and C. V. Suryavanshi, “A process for the preparation of antipschotic 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1
-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2,-]pyrimidin-4-one,” (RRG Life Sciences). Limited, India) PCT International Application WO 2001085731 A20011115, 2001.
- K. L. E. Josephine, P. S. M. Aloysius, and B. F. Paul, “Benzothieno[3,2-c]pyridines as 2 antagonists,” (Janssen Pharmaceutica N.V. Belg.) PCT International Application WO 2000020422 Al 20000413, 2000, Chemical Abstracts, 132, 265188t.
- K. L. E. Josehine, V. D. Keybus, F. M. Alfons, and M. J. Carolus, “Tricyclic g(d)3-piperidines as g(a)2-antagonists,” PCT International Application WO 2000020421 A2 200002413, 2000,
Chemical Abstracts, 132, 265187c.
- L. E. J. Kennis, F. P. Bischoff, C. J. Mertens, et al., “New 2-substituted 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine having highly active and potent central -antagonistic activity as potential antidepressants,” Bioorganic & Medicinal Chemistry Letters, vol. 10, no. 1, pp. 71–74, 2000. View at Publisher · View at Google Scholar
- K. L. E. Josephine, C. J. Love, and P. F. Bischoff, “1,2,3,4-tetrahydro-benzofuro[3,2-c]pyridine derivatives,” PCT International Application WO/1998/045297 Al 19981015, 1998,
Chemical Abstracts, 129, 302654c.
- C. J. Coulson, R. E. Ford, E. Hunt, et al., European Journal of Medicinal Chemistry, vol. 9, p. 13, 1974.
- H. Wamhoff and F. Korte, “The synthesis of heterocyclic compounds starting from lactones, lactams, and thiollactones,” Synthesis, vol. 1972, no. 4, pp. 151–175, 1972. View at Publisher · View at Google Scholar
- H. J. Willenbrock, H. Wamhoff, and F. Korte, “Über Reactions des -Acetyl-γ-butyrolactones mit heterocyclishen Amines,” Justus Liebigs Annalen der Chemie, vol. 1, p. 103, 1973.
- R. B. Toche, B. K. Ghotekar, M. A. Kazi, D. B. Kendre, and M. N. Jachak, “Synthesis of fused pyrimidines from amines and cyclic -formylesters,” Tetrahedron, vol. 63, no. 34, pp. 8157–8163, 2007. View at Publisher · View at Google Scholar