|
| Patients | Premedication dose route | Steps | Duration | Success rate |
|
| Abe et al. (2010) [50] | 3 (carboplatin replaced by cisplatin after desensitization) | Dexamethasone 20 mg, promethazine 50 mg, ranitidine 50 mg | From 1 : 1000 to 1 : 10 on 1st day (in 3 steps), from 1 : 10 to 1 : 1 on 2nd day (in 2 steps) | 2 days (3 hours on 1st day, 9 hours on 2nd day) | 100% |
|
| Gomez et al. (2009) [51] | 7 | Dexamethasone at least 20 mg iv 30, clemastine 2 mg iv | From 1 : 1000 to 1 : 1 in 4 steps | 2 hours | 71% |
|
| Hesterberg et al. (2009) [52] | 30 | Fexofenadine 180 mg po and/or desloratadine 5 mg po BID, Dexamethasone 10 mg po | From 1 : 100 to 1 : 1 (in 8–10 steps) | 11 hours | 99% |
|
| Castells et al. (2008) [53] | 63 (60 hypersensitive to carboplatin, 3 to cisplatin) | Diphenhydramine or hydroxyzine 25 mg po or iv, famotidine 20 mg iv or ranitidine 50 mg iv, lorazepam (0.5-1 mg po or iv as needed for anxiety) | From 1 : 100 to 1 : 1 in 12 steps | 5.8 hours | Severe reactions in 6% of courses (full target dose with treatment) |
|
| Confino-Cohen et al. (2005) [54] | 23 | Dexamethasone 8–12 mg iv, ondansetron iv | From 1 : 1000 to 1 : 1 in 4 steps | 6 hours | 86.9% |
|
| Lee et al. (2005) [55] | 31 (1st desensitization in intensive care unit—subsequent as outpatient) | Diphenhydramine 25 mg iv, famotidine 20 mg iv Lorazepam 1 mg (as needed for anxiety) | From 1 : 100 to 1 : 1 in 12 steps(higher concentrations as outpatient) | 5.8 hours (inpatient) 3.8 hours (outpatient) | 85% courses without symptoms (full target dose with treatment) |
|
| Markman et al. (2004) [56] | 5 (desensitization and retreatment with carboplatin or cisplatin) | Zileuton 600 mg po QID (5 days), montelukast sodium 10 mg po QD (5 days), indomethacin 50 mg po TID (1 day), albuterol sulfate 8 mg po BID (1 day), famotidine 20 mg iv, dexamethasone 20 mg iv, diphenhydramine 50 mg iv | From 1 : 1000 to 1 : 1 in 4 steps | 90 minutes | 80% |
|
| Jones et al. (2003) [57] | 5 (carboplatin replaced by cisplatin after desensitization) | Dexamethasone 20 mg po (4 days ), diphenhydramine 50 mg po (4 days), ranitidine 50 mg iv, dexamethasone 20 mg iv, ondansetron 8 mg iv | From 1 : 1000 to 1 : 1 in 4 steps | 2 hours | 60% |
|
| Rose et al. (2003) [33] | 33 | Dexamethasone 20 mg po or iv 6 hours before, Dexamethasone 20 mg iv and diphenhydramine 50 mg iv 30 minutes before | From 1 : 1000 to 1 : 1 in 4 steps | 16.5 hours | 79% |
|
