Review Article
Hypersensitivity Reactions Associated with Platinum Antineoplastic Agents: A Systematic Review
Table 5
Castells’ 12-step desensitization protocol.
| | Step | Solution | Rate (mL/h) | Time (in minutes) | Volume infused per step (mL) |
| | 1 | 100-fold dilution of final target concentration | 2.0 | 15 | 0.50 | | 2 | 5.0 | 15 | 1.25 | | 3 | 10.0 | 15 | 2.50 | | 4 | 20.0 | 15 | 5.00 |
| | 5 | 10-fold dilution of final target concentration | 5.0 | 15 | 1.25 | | 6 | 10.0 | 15 | 2.50 | | 7 | 20.0 | 15 | 5.00 | | 8 | 40.0 | 15 | 10.00 |
| | 9 | Concentration was calculated by subtracting the cumulative dose administered in steps 1–8 from the total target dose | 10.0 | 15 | 2.50 | | 10 | 20.0 | 15 | 5.00 | | 11 | 40.0 | 15 | 10.00 | | 12 | 75.0 | prolonged to complete target dose | 232.50 |
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