Research Article
Targeted Disruption of Calcium/NFAT Signaling Reveals a Left-Right Determination Disorder in the Pharyngeal Arch Artery
Table 1
Appearance of right aortic arch after injection to mother mouse.
| Drugs | of fetuses | % of right aortic arch + right ductus arteriosus | % of other abnormalities |
| FK506 | | | | 6.0 mg/kg | 3 | 0 | 33 | 3.0 mg/kg | 31 | 32 | 0 | 0.8 mg/kg | 30 | 23 | 3 | 0.05 mg/kg | 13 | 0 | 0 | Saline | 34 | 0 | 0 | FTY720 | | | | 6.0 mg/kg | 8 | 0 | 0 | 3.0 mg/kg | 26 | 0 | 0 | Saline | 32 | 0 | 0 | Rapamycin | | | | 1.0 mg/kg | 8 | 0 | 0 | 0.1 mg/kg | 16 | 0 | 0 | 0.01 mg/kg | 14 | 0 | 0 | Saline | 24 | 0 | 0 |
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Injection was performed during 6.5, 7.5, and 8.5 days after pregnancy.
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