Targeted Disruption of Calcium/NFAT Signaling Reveals a Left-Right Determination Disorder in the Pharyngeal Arch Artery

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">Drugs</td><td align="center">% of right aortic arch + right ductus arteriosus</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">siRNA of NFATc4</td><td align="center">31 (11/35)</td></tr><tr><td align="left">siRNA of NFATc1</td><td align="center">Embryonic lethal</td></tr><tr><td align="left">Phosphate buffer (pH 7.4)</td><td align="center">20 (6/30)</td></tr><tr><td align="left"><i> </i>Saline</td><td align="center">  0 (0/24)</td></tr><tr><td align="left"><i> </i>KCL</td><td align="center">  0 (0/18)</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Appearance of right aortic arch after infusion of NFATc4 siRNA into amniotic fluid.

Developmental Biology Journal

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Table 3

Table 3: Targeted Disruption of Calcium/NFAT Signaling Reveals a Left-Right Determination Disorder in the Pharyngeal Arch Artery 