The modulation reestablishes the apoptosis, the natural cell-killing process, and after 48 h, the effect is obviously acting. Immediately after the treatment, there is no difference between the samples, but 24 hours later, the difference is obvious (HT29 xenograft model on single-tumor-bearing mice, heating single shot, 30 min to 42°C. Animals were sacrificed 24 h after the treatment).