|
Trial | Kapp et al. [7] | Perez et al. [5] | Emami et al. [8] | Engin et al. [9] | Vernon et al. [10] | Overgaard et al. [11] | Jones et al. [12] |
|
Organization | Stanford University | Mallinckrodt Institute of Radiology | Mallinckrodt Institute of Radiology | Thomas Jefferson University | Some European and Canadian centers | Danish Cancer Society | Duke University |
Country | USA | USA | USA | USA | Europe/Canada | Europe | USA |
Year of publication | 1990 | 1991 | 1992 | 1993 | 1996 | 1996 | 2005 |
Design | Monocenter | Monocenter | Monocenter | Monocenter | Multicenter | Multicenter | Monocenter |
Number of patients | 70 | 307 | 173 | 41 | 236 | 70 | 108 |
Number of tumors | 179 | N/D | 240 | 44 | N/D | 134 | N/D |
Type of tumors | Chest wall, neck nodes, melanoma | Chest wall, neck nodes, melanoma | Superficial | Chest wall, neck nodes | Chest wall | Melanoma | Chest wall, neck nodes, melanoma |
Therapy | | | | | | | |
HT+ | RT + HT 42.5°C (6 HTs) | RT + HT 42.5°C × 45–60′ (2 HTs) | RT + HT 42.5°C (8 HTs) | RT + HT 42.5°C (8 HTs) | RT + HT 42.5°C | RT + HT 43°C × 60′ (3 HTs) | RT + HT 10 < CEM43°C < 100 (10 HTs) |
HT− | RT + HT 42.5°C (2 HTs) | RT only | RT + HT 42.5°C (4 HTs) | RT + HT 42.5°C (4 HTs) | RT only | RT | RT |
Complete local response (%) | | | | | | | |
HT+ | 52% | 32% | 57.8% | 55% | 59% | 62% (immed.)/46% (2 yr) | 66% |
HT− | 51% | 30% | 54.7% | 59% | 41% | 35% (immed.)/28% (2 yr) | 42% |
Overall survival | | | | | | | |
HT+ |
N/D |
Statistically insignificant |
Statistically insignificant |
N/D |
Statistically insignificant |
Statistically insignificant |
Statistically insignificant |
HT− |
Disease-free survival | | | | | | | |
HT+ |
N/D | Enhanced |
N/D |
N/D | Enhanced |
N/D | Enhanced |
HT− | | | |
Burns | | | | | | | |
HT+ |
N/D | 30% |
N/D | 40% | 11% |
N/D | 46% |
HT− | 0% | 40% | 2% | 5.7% |
Complications (overall) | | | | | | | |
HT+ | 5% needed medication; 3% needed surgery | N/D | 18% of severe complications | N/D | Pain | 27% pain, incl. 8% moderate and 6% severe | 16% needed pause of treatment |
Authors estimation | Negative | Negative | Negative | Negative | Positive | Positive | Positive |
Final estimation | Negative | Negative | Negative | Negative | Dubious | Dubious | Dubious |
|