Conference Papers in Science

Conference Paper

Critical Analysis of Electromagnetic Hyperthermia Randomized Trials: Dubious Effect and Multiple Biases

Table 2

Clinical results of Vernon et al. trial [10].


	DHG		MRC BrI		MRC BrR		ESHO		PMH		TOTAL
	RT	TRT	RT	TRT	RT	TRT	RT	TRT	RT	TRT	RT	TRT

Total	19	19	12	18	59	90	29	27	16	17	135	171

CR	14	14	8	10	17	51	11	21	5	5	55	101
%	74c	74%	67%	56%	29%	57%	38%	78%	31%	29%	41%	59%
Difference	0%		−11%		28%		40%		−2%		18%
OR	1		0,65		3,23		5,73		0,92		2,3
Local recurrence after CR	6	3	0	1	6	3	4	8	1	2	17	17
%	32%	16%	0%	6%	10%	3%	14%	30%	6%	12%	13%	10%
Difference	−16%		6%		−7%		16%		6%		−3%
Progression elsewhere	9	11	2	3	12	42	7	18	1	1	31	75
%	47%	58%	17%	17%	20%	47%	24%	67%	6%	6%	23%	44%
Difference	11%		0%		26%		43%		0%		21%
Dead	2	6	2	4	9	36	3	6	0	0	16	52
%	11%	32%	17%	22%	15%	40%	10%	22%	0%	0%	12%	30%
Difference	21%		6%		25%		12%		0%		19%

No CR	5	5	4	8	42	39	18	8	11	12	80	70
%	26%	26%	33%	44%	71%	43%	62%	30%	69%	71%	59%	41%
Difference	0%		11%		−28%		−32%		2%		−18%
Progression elsewhere	5	3	4	5	33	31	14	5	10	11	66	55
%	26%	16%	33%	28%	56%	34%	48%	19%	63%	65%	49%	32%
Difference	−11%		−6%		−21%		−30%		2%		−17%
Dead	4	3	4	5	35	36	9	4	6	6	58	54
%	21%	16%	33%	28%	59%	40%	31%	15%	38%	35%	43%	32%
Difference	−5%		−6%		−19%		−16%		−2%		−11%

All patients
Actuarial survival at 2 years	12	13	15	12	6	5	11	10	17	13	5	4
%	65%	62%	48%	44%	32%	21%	42%	68%	46%	59%	41%	36%
Difference	−3%		−4%		−11%		26%		13%		−5%
Progression elsewhere	14	14	6	8	45	73	21	23	11	12	97	130
%	74%	74%	50%	44%	76%	81%	72%	85%	69%	71%	72%	76%
Difference	0%		−6%		5%		13%		2%		4%
Dead	6	9	6	9	44	72	12	10	6	6	74	106
%	32%	47%	50%	50%	75%	80%	41%	37%	38%	35%	55%	62%
Difference	16%		0%		5%		−4%		−2%		7%