Conference Papers in Science

Conference Paper

Small Changes in Cardiac Troponin Levels Are Common in Patients with Myocardial Infarction: Diagnostic Implications

Table 1

Studies reporting cTn change in patients with myocardial infarction.


Study cohort	Number of patients in study	Number of patients with MI	Only NSTEMI	Percent of MI patients with <20–25% cTn change during study	Percent of MI patients with <30% cTn change during study	Percent of MI patients with <50–60% cTn change during study	Time during which cTn change was evaluated in the study (h)	cTn change recorded during the hospital stay required for diagnosis	cTn assay used	Symptom time (h)^b	Reference

Suspected ACS in ER	332	110	No	28%	NR	38%	9.4	No	Roche cobas/E170 hs-cTnT	4	[16]

Suspected ACS in ER and patients admitted to the hospital	784	165	Yes	25%	NR	47%	6	>20% or >5 ng/L	Roche cobas/E170 hs-cTnT	NR*	[14]

Suspected ACS in ER	454	142	No	5%^#	NR	11%	24	>20%	Siemens Stratus CS TnI		[17]

Suspected ACS in ER	381	51	No	25%	25%	NR	6	>20%	Ortho VITROS TnI	3.9	[19]

Suspected ACS in ER	939	200	Yes	51%	0.62	NR	2	No	Roche cobas/E170 hs-cTnT	NR	[18]

Suspected ACS in ER	1818	413	No	23%	27%	33%	3	>20%	Abbott Architect STAT high sensitive TnI	4.3	[20]

Suspected ACS in ER	590	65	Yes	36%	NR	50%	2	>4.2 ng/L	Roche cobas/E170 hs-cTnT		[13]

NR: not reported. ACS: acute coronary syndrome. MI: myocardial infarction. CCU: coronary care unit. ER: emergency room. NSTEMI: non ST-elevation myocardial infarction. Median time since start of symptom at baseline in hours. Median symptom time 20 h if <20% change, and median symptom time 12 h if >20% change. Symptom time <8 h or <12 h respectively required for inclusion in study. 16% had a <20% cTnI change at 6 h.