Bone marrow specimen of the patient with systemic mastocytosis. (a) Diffuse infiltration of the bone marrow with neoplastic mast cells and massive displacement of hematopoetic cells (HE). (b) Induction of myelofibrosis by neoplastic cells (modified Gomori stain). (c) Residual hematopoiesis besides neoplastic infiltrates (HE). (d) Giemsa staining shows cytoplasmatic granules of neoplastic mast cells 200.