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| (1) The site of origin must be within the field of previous radiation | |
| (2) The patient should have received a significant amount of radiation therapy (greater than 2,500 rads) | |
| (3) An interval of at least 3–5 years must elapse between the time of irradiation and the development of the sarcoma | |
| (4) The second primary cancer needs to be histologically different from the primary neoplasm | |
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