Case Reports in Pathology
Volume 2012 (2012), Article ID 427628, 3 pages
Melanocyte Colonization and Pigmentation of Breast Carcinoma: Pathological and Clinical Aspects
1Department of Endocrine and Breast Surgery, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
2Department of Pathology, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark
3Department of Plastic Surgery, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark
Received 18 November 2012; Accepted 6 December 2012
Academic Editors: E. Miele, D. Miliaras, A. Pich, and D. Tsuruta
Copyright © 2012 Marco Mele et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Introduction. Melanocyte colonization of breast carcinoma by nonneoplastic melanocytes of epidermal origin is a rare and serious condition first described in 1977. We report on the exceptional clinical and pathological features of this migration phenomenon in a 74-year-old patient. Discussion. The pathogenesis by which melanocyte migration takes place is not known, but a breached basement membrane is considered essential. Conclusion. Histological examination and additional staining of skin are essential to differentiate breast cancer melanosis from malignant melanoma.