Adverse events after tocilizumab therapy. (a), (b) Photographs show the bilateral fundus images of retinopathy with bilateral multiple cotton-wool spots and retinal hemorrhages around the optic disc. (c), (d), and (e) Rashes on the palms and planta pedis resemble pustulosis palmoplantaris, and (f) diffuse pruritic erythema around the lumbar region appeared 20 days after the first infusion of tocilizumab. (g) Skin ulceration on the right external malleolus appeared immediately after the second infusion of tocilizumab.