- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Submit a Manuscript
- Table of Contents
Case Reports in Urology
Volume 2013 (2013), Article ID 651081, 4 pages
Renal Cell Carcinoma Metastatic to Thyroid Gland, Presenting Like Anaplastic Carcinoma of Thyroid
1Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City, Riyadh 59046, Saudi Arabia
2Histopathology and Cytopathology, King Fahad Medical City, Riyadh 59046, Saudi Arabia
Received 27 February 2013; Accepted 26 March 2013
Academic Editors: G. Lombardi and F. M. Solivetti
Copyright © 2013 Khalid Riaz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background. Renal cell carcinoma (RCC) has unpredictable and diverse behavior. The classic triad of hematuria, loin pain, and abdominal mass is uncommon. At time of diagnosis, 25%–30% of patients are found to have metastases. Bones, lungs, liver, and brain are the frequent sites of metastases. RCC with metastasis to the head and neck region and thyroid gland is the rarest manifestation and anaplastic carcinoma behaving metastatic thyroid mass is an extremely rare presentation of RCC. Case Presentation. A 56-year-old Saudi man with past history of right radical nephrectomy 5 years back presented with 3 months history of rapid increasing neck mass with dysphagia, presenting like anaplastic thyroid carcinoma. Tru-cut biopsy turned out to be metastatic renal cell carcinoma. Patient was treated with radiation therapy 30 Gy in 10 fractions to mass. Patient died 4 months after the discovery of anaplastic thyroid looking metastasis. Conclusion. Rapidly progressing thyroid metastases secondary to RCC are rare and found often unresectable which are not amenable to surgery. Palliative radiotherapy can be considered for such patients.
Renal cell carcinoma (RCC) has unpredictable and diverse behavior. Due to widespread use of modern imaging, the incidence of RCC over last 20 years has progressively increased . About 30%–50% of patients are found to have metastases at the time of diagnosis. While bone, lymph nodes, lungs, and brain constitute expected metastatic sites, metastasis may turn up at the unusual locations (skin, testis, maxillary antrum, and cervix) [2–4].
Metastasis of RCC to the head and neck region is rare manifestation [5, 6]. The breast and lung cancers are known to metastasize to the thyroid and in some cases they are detected only at autopsy .
The common presenting symptoms of metastatic RCC to the thyroid gland are enlarged solitary or multiple neck swellings, dysphagia, and dyspnea depending on the location and the extent of invasion by metastatic deposits . To differentiate a primary thyroid malignancy from RCC, the clinical and radiographic findings are often nonspecific; however, the histopathological and immunohistochemical features are sufficiently distinctive.
Herein, a rare case of thyroid gland metastasis presenting like anaplastic thyroid cancer following an open right radical nephrectomy five years back in a 56-year-old male with a stage pT2N0 M0 and Fuhrman grade II RCC is reported.
2. Case Presentation
A 56-year-old Saudi man presented during routine followup with neck swelling and hoarse voice. He had noticed this swelling for 3 months and it had been rapidly increasing in size over a week causing dyspnea and dysphagia to solids. His previous medical history revealed that, five years back, he underwent left radical nephrectomy; the histopathological findings were consistent with papillary cell type renal cell carcinoma (Figure 1). Tumor was not infiltrating through the capsule. Hilar vessels, margins, and bladder cuff were free of tumor. Stage was made pT2N0 M0. He had no other medical comorbidities and no history of smoking and her weight was stable.
On physical examination, there was hard fixed palpable in thyroid gland. The rest of examination was normal. Computed tomography (CT) scan of his neck was performed which revealed a mass of 8 × 7.5 cm size in right lobe of thyroid gland with vascular enhancement (Figure 2). No cervical lymphadenopathy was found and postnephrectomy renal bed was clear. The bone scan and CT chest revealed no other distant metastases. Differential diagnosis was anaplastic thyroid carcinoma or lymphoma.
Subsequently tru-cut biopsy was taken from thyroid mass, which revealed clear cell histology, and immunohistochemistry revealed CD10 positivity and TTF-1 negativity (Figure 3). Findings were consistent with metastatic RCC. Patient was given palliative radiotherapy 30 Gy in 10 fractions to relieve the obstructive symptoms as tumor was unresectable and then he was started on sunitinib 50 mg orally daily. Patient died 4 months after the discovery of thyroid metastasis.
Metastasis to the thyroid gland is an uncommon manifestation. However, autopsy results show that 1.9% to 22.4% of patients with generalized malignancies have metastasis to the thyroid gland . According to one large autopsy series, malignant melanoma (39%) and breast carcinoma (21%) and lung account for the largest number of tumors metastasizing to the thyroid gland as part of widely disseminated disease (excluding lymphoma and leukemia) and thyroid gland metastases from renal cell carcinoma are rarest  and further anaplastic like presentation of thyroid metastasis is extremely rare.
Although micrometastases are present in about 25% of RCCs at the time of the diagnosis of the primary malignancy (synchronous), metastatic disease can develop as part of the latency of the tumor with delayed development of metastases after many years of dormancy (metachronous) as seen in our patient .
The thyroid gland is one of the most vascularized organs in the body and one would expect it to be the site of metastatic disease. It has been suggested that the thyroid gland, when altered by goiter, neoplasms, or thyroiditis, is more vulnerable to metastatic growth due to metabolic changes with a decrease in oxygen and iodine content .
Surgical treatment of patients with solitary thyroid gland metastases is recommended because of the unusually good prognosis in patients reported in the literature when they were treated with definitive surgical therapy with mean 5-year survival rate 30–60% . However our patient was treated with radiation therapy as the tumor was unresectable.
In conclusion, thyroid metastases secondary to RCC are rare and the importance of this case lies in the fact that, on initial presentation, it mimicked the rapid growth of anaplastic thyroid carcinoma, for such cases radiation therapy can be an option.
Conflict of Interests
The authors have no potential conflict of interests, and no grants or funds were received for this case report.
Written informed consent was taken from patient for the publication of this case report.
- M. A. Tunio, A. Hashmi, and M. Rafi, “Need for a new trial to evaluate postoperative radiotherapy in renal cell carcinoma: a meta-analysis of randomized controlled trials,” Annals of Oncology, vol. 21, no. 9, pp. 1839–1845, 2010.
- M. A. Tunio, A. Hashmi, and M. Rafi, “Epistaxis and proptosis—unusual primary manifestations of metastatic renal cell carcinoma,” Pakistan Journal of Medical Sciences, vol. 25, no. 6, pp. 1012–1014, 2009.
- M. A. Tunio, A. Hashmi, and M. Rafi, “Renal cell carcinoma presenting as skin and ipsilateral testicular metastasis,” Isra Medical Journal, vol. 1, pp. 79–81, 2009.
- M. Arifi, K. Riaz, M. A. Tunio, and M. Asiri, “Uterine cervix metastasis as an initial manifestation of metastatic renal cell carcinoma: a case report and review of literature,” Journal of Nuclear Medicine & Radiation Therapy, vol. 6, pp. 1–3, 2012.
- M. A. Tunio, M. Asiri, S. Ahmad, and M. Fareed, “Tongue metastasis as an initial manifestation of metastasis in renal cell carcinoma: a case report,” Journal of Solid Tumors, vol. 2, pp. 39–42, 2012.
- M. A. Tunio, M. Asiri, Y. Bayoumi, M. Fareed, and S. Ahmad, “Thyroid gland as an initial site of delayed metastasis from renal cell carcinoma: a case report,” Journal of Solid Tumors, vol. 2, pp. 50–52, 2012.
- C. S. Heffess, B. M. Wenig, and L. D. Thompson, “Metastatic renal cell carcinoma to the thyroid gland: a clinicopathologic study of 36 cases,” Cancer, vol. 95, no. 9, pp. 1869–1878, 2002.
- A. Lasser, J. G. Rothman, and V. J. Calamia, “Renal-cell carcinoma metastatic to the thyroid. Aspiration cytology and histologic findings,” Acta Cytologica, vol. 29, no. 5, pp. 856–858, 1985.
- M. Kihara, H. Yokomise, and A. Yamauchi, “Metastasis of renal cell carcinoma to the thyroid gland 19 years after nephrectomy: a case report,” Auris Nasus Larynx, vol. 31, no. 1, pp. 95–100, 2004.
- H. L. Koo, J. Jang, S. J. Hong, Y. Shong, and G. Gong, “Renal cell carcinoma metastatic to follicular adenoma of the thyroid gland: a case report,” Acta Cytologica, vol. 48, no. 1, pp. 64–68, 2004.
- A. Machens and H. Dralle, “Outcome after thyroid surgery for metastasis from renal cell cancer,” Surgery, vol. 147, no. 1, pp. 65–71, 2010.