Case Reports in Veterinary Medicine
Volume 2013 (2013), Article ID 357645, 5 pages
Addisonian Crisis due to Metastatic Adenocarcinoma in a Pygmy Goat
1William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, One Shield Avenue, Davis, CA 95616, USA
2Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California Davis, Davis, One Shield Avenue, Davis, CA 95616, USA
3Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California Davis, Davis, One Shield Avenue, Davis, CA 95616, USA
4Department of Veterinary Medicine and Surgery, University of Missouri, 900 East Campus Drive, Columbia, MO 65211, USA
Received 31 May 2013; Accepted 18 July 2013
Academic Editors: N. D. Giadinis, C. Hyun, L. G. Papazoglou, and M. Pizarro
Copyright © 2013 Nora Nogradi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
A 15-year-old Pygmy doe was evaluated for acute onset of lethargy, anorexia, and weakness. Adrenal insufficiency was diagnosed based on physical exam findings, blood work abnormalities (hyponatremia, hyperkalemia, azotemia, and hypoglycemia), and lack of cortisol response to the ACTH stimulation test. Abdominal ultrasound exam revealed an intact urinary tract and multiple bilateral peri-renal masses. The doe was treated with intravenous fluid therapy aimed at correcting the electrolyte abnormalities and intravenous corticosteroids. She responded favorably to medical therapy in 24 hours, with dramatic improvement in attitude and appetite. Fluid therapy was discontinued, and the doe was discharged from the hospital on steroid supplementation. She deteriorated rapidly and died at home 36 hours after discharge. Necropsy results revealed metastatic adenocarcinoma originating from the uterus that infiltrated the urinary bladder, the region of the adrenal glands, the left and right renal lymph nodes, the left kidney, the caudal vena cava, the submandibular lymph nodes, the diaphragm, the lungs, and the omentum. Addison’s syndrome in ruminants should be considered as an uncommon sequel of intra-abdominal neoplastic processes.