Table 1: Predictive parameters of asthma persistence at follow-up end point (univariate analysis).

Persistent Remission P value Atopic dermatitis 85 (70.3%) 39 (36.8%) <0.001 Sensitization to ≥2 food allergens 15 (12.4%) 4 (3.7%) 0.02 Sensitization to ≥2 airborne allergens 40 (33.1%) 7 (6.6%) <0.001 Allergen polysensitization 47 (38.8%) 12 (11.3%) <0.001 Total serum IgE >45 IU/mL 59 (48.8%) 30 (28.3%) 0.002 Blood eosinophil count ≥470/mm3 39 (32.2%) 15 (14.2%) 0.001 Mother with asthma 27 (22.5%) 20 (19.1%) 0.52 Father with asthma 28 (23.3%) 19 (18.6%) 0.33 Initial severity 62 (51.2%) 34 (32.1%) 0.004

Allergen sensitization: presence of allergen-specific IgE ≥0.35 kU/L to at least one of the common aeroallergens (dust mites, cat or dog dander, seed plant, or birch pollen) or one of the common food allergens (cow’s milk, eggs, peanuts, wheat, soybean, and fish). Allergen sensitization was single or multiple (≥2 specific food allergen-positive IgE or ≥2 specific airborne allergen-positive IgE). Allergen polysensitization was defined as ≥2 allergen-specific IgE, regardless of allergen class. Initial severity: two previous hospital admissions due to exacerbation. Hypereosinophilia: absolute eosinophil count of ≥470/ mm3.