MicroPET/CT Imaging of [18F]-FEPPA in the Nonhuman Primate: A Potential Biomarker of Pathogenic Processes Associated with Anesthetic-Induced Neurotoxicity
Figure 6
Electron micrograph (EM) showing a normal pyramidal neuron in the frontal cortex with intact cytoplasm and nuclear membrane from a control infant monkey (a). EM figure showing nuclear condensation (advanced state of apoptosis) and mitochondrial swelling and typical cell body swelling (necrosis) of pyramidal neurons (note nucleolus in the nucleus) in the frontal cortex (b) from a subject exposed to the inhaled anesthetic combination (N2O + ISO) for 8 h. Nu = nucleus. Cyt = cytoplasm. Scale bar = 0.5 μm.
