Volume 2012 (2012), Article ID 707586, 6 pages
Withaferin A Induces Proteasome-Dependent Degradation of Breast Cancer Susceptibility Gene 1 and Heat Shock Factor 1 Proteins in Breast Cancer Cells
1Department of Surgery, University of Kansas School of Medicine, Kansas City, KS 66160, USA
2Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS 66045, USA
Received 23 May 2012; Accepted 1 August 2012
Academic Editors: A. Azem, A.-M. Lambeir, B. Penke, and A. Tavares
Copyright © 2012 Xuan Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- P. Uma Devi, “Withania somnifera dunal (Ashwagandha): potential plant source of a promising drug for cancer chemotherapy and radiosensitization,” Indian Journal of Experimental Biology, vol. 34, no. 10, pp. 927–932, 1996.
- S. D. Stan, Y. Zeng, and S. V. Singh, “Ayurvedic medicine constituent withaferin a causes G2 and M phase cell cycle arrest in human breast cancer cells,” Nutrition and Cancer, vol. 60, no. 1, pp. 51–60, 2008.
- S. D. Stan, E. R. Hahm, R. Warin, and S. V. Singh, “Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo,” Cancer Research, vol. 68, no. 18, pp. 7661–7669, 2008.
- M. Kaileh, W. Vanden Berghe, A. Heyerick et al., “Withaferin A strongly elicits IκB kinase β hyperphosphorylation concomitant with potent inhibition of its kinase activity,” Journal of Biological Chemistry, vol. 282, no. 7, pp. 4253–4264, 2007.
- S. Koduru, R. Kumar, S. Srinivasan, M. B. Evers, and C. Damodaran, “Notch-1 inhibition by withaferin-A: a therapeutic target against colon carcinogenesis,” Molecular Cancer Therapeutics, vol. 9, no. 1, pp. 202–210, 2010.
- Y. Yu, A. Hamza, T. Zhang et al., “Withaferin A targets heat shock protein 90 in pancreatic cancer cells,” Biochemical Pharmacology, vol. 79, no. 4, pp. 542–551, 2010.
- J. Lee, E. R. Hahm, and S. V. Singh, “Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells,” Carcinogenesis, vol. 31, no. 11, pp. 1991–1998, 2010.
- P. Bargagna-Mohan, A. Hamza, Y. E. Kim et al., “The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin,” Chemistry and Biology, vol. 14, no. 6, pp. 623–634, 2007.
- R. J. Linger and P. A. Kruk, “BRCA1 16 years later: risk-associated BRCA1 mutations and their functional implications,” FEBS Journal, vol. 277, no. 15, pp. 3086–3096, 2010.
- J. T. Holt, M. E. Thompson, C. Szabo et al., “Growth retardation and tumour inhibition by BRCA1,” Nature Genetics, vol. 12, no. 3, pp. 298–302, 1996.
- M. Boettcher, J. Fredebohm, A. M. Gholami et al., “Decoding pooled RNAi screens by means of barcode tiling arrays,” BMC Genomics, vol. 11, no. 1, article 7, 2010.
- W. Liu, W. Zong, G. Wu et al., “Turnover of BRCA1 involves in radiation-induced apoptosis,” PLoS ONE, vol. 5, no. 12, Article ID e14484, 2010.
- F. Rastelli, S. Biancanelli, A. Falzetta et al., “Triple-negative breast cancer: current state of the art,” Tumori, vol. 96, no. 6, pp. 875–888, 2010.
- L. Meng, V. L. Gabai, and M. Y. Sherman, “Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis,” Oncogene, vol. 29, no. 37, pp. 5204–5213, 2010.
- S. K. Calderwood, “Heat shock proteins in breast cancer progression—a suitable case for treatment?” International Journal of Hyperthermia, vol. 26, no. 7, pp. 681–685, 2010.
- C. Dai, L. Whitesell, A. B. Rogers, and S. Lindquist, “Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis,” Cell, vol. 130, no. 6, pp. 1005–1018, 2007.
- N. Zaarur, V. L. Gabai, J. A. Porco Jr., S. Calderwood, and M. Y. Sherman, “Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors,” Cancer Research, vol. 66, no. 3, pp. 1783–1791, 2006.
- X. Zhang, A. K. Samadi, K. F. Roby, B. Timmermann, and M. S. Cohen, “Inhibition of cell growth and induction of apoptosis in ovarian carcinoma cell lines CaOV3 and SKOV3 by natural withanolide Withaferin A,” Gynecologic Oncology, vol. 124, no. 3, pp. 606–612, 2012.
- X. Zhang, R. Mukerji, A. K. Samadi, and M. S. Cohen, “Down-regulation of estrogen receptor-alpha and REarranged during Transfection tyrosine kinase is associated with Withaferin A-induced apoptosis in MCF-7 breast cancer cells,” BMC Complementary and Alternative Medicine, vol. 11, pp. 84–93, 2011.
- C. I. Holmberg, S. A. Illman, M. Kallio, A. Mikhailov, and L. Sistonen, “Formation of nuclear HSF1 granules varies depending on stress stimuli,” Cell Stress and Chaperones, vol. 5, no. 3, pp. 219–228, 2000.
- M. Sano, S. Tokudome, N. Shimizu et al., “Intramolecular control of protein stability, subnuclear compartmentalization, and coactivator function of peroxisome proliferator-activated receptor γ coactivator 1α,” Journal of Biological Chemistry, vol. 282, no. 35, pp. 25970–25980, 2007.
- A. D. Choudhury, H. Xu, and R. Baer, “Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression,” Journal of Biological Chemistry, vol. 279, no. 32, pp. 33909–33918, 2004.
- C.-X. Deng and S. G. Brodie, “Roles of BRCA1 and its interacting proteins,” BioEssays, vol. 22, no. 8, pp. 728–737, 2000.
- I. Bae, S. Fan, Q. Meng et al., “BRCA1 induces antioxidant gene expression and resistance to oxidative stress,” Cancer Research, vol. 64, no. 21, pp. 7893–7909, 2004.
- V. L. Gabai, L. Meng, G. Kim, T. A. Mills, I. J. Benjamin, and M. Y. Sherman, “Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR,” Molecular and Cellular Biology, vol. 32, no. 5, pp. 929–940, 2012.
- S. Santagata, R. Hu, N. U. Lin et al., “High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 45, pp. 18378–18383, 2011.