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ISRN Cardiology
Volume 2012 (2012), Article ID 180710, 13 pages
doi:10.5402/2012/180710
Review Article
Carotid Artery Disease and Stroke: Assessing Risk with Vessel Wall MRI
1Department of Radiology, University of Washington, Seattle, WA 98109, USA
2VPDiagnostics Incorporation, Seattle, WA 98101, USA
Received 26 August 2012; Accepted 3 October 2012
Academic Editors: A. Becker, F. Quaini, and J. J. van Lieshout
Copyright © 2012 William S. Kerwin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- S. L. Murphy, J. Xu, and K. D. Kochanek, “Deaths: preliminary data for 2010,” National Vital Statistics Reports, vol. 60, no. 4, pp. 1–51, 2012.
- World Health Organization, “Cardiovascular diseases (CVDs),” Fact Sheet no. 317, 2011.
- R. J. Wityk, D. Lehman, M. Klag, J. Coresh, H. Ahn, and B. Litt, “Race and sex differences in the distribution of cerebral atherosclerosis,” Stroke, vol. 27, no. 11, pp. 1974–1980, 1996. View at Scopus
- T. M. Dumont and A. I. Rughani, “National trends in carotid artery revascularization surgery: clinical article,” Journal of Neurosurgery, vol. 116, no. 6, pp. 1251–1257, 2012. View at Publisher · View at Google Scholar · View at Scopus
- D. W. Taylor and H. J. M. Barnett, “Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis,” The New England Journal of Medicine, vol. 325, no. 7, pp. 445–453, 1991. View at Scopus
- J. F. Toole, “Endarterectomy for asymptomatic carotid artery stenosis,” JAMA, vol. 273, no. 18, pp. 1421–1428, 1995. View at Publisher · View at Google Scholar · View at Scopus
- A. L. Abbott and G. A. Donnan, “Does the “high risk” patient with asymptomatic carotid stenosis really exist?” European Journal of Vascular and Endovascular Surgery, vol. 35, no. 5, pp. 524–533, 2008. View at Publisher · View at Google Scholar · View at Scopus
- P. A. Schneider and A. R. Naylor, “Transatlantic debate. asymptomatic carotid artery stenosis-medical therapy alone versus medical therapy plus carotid endarterectomy or stenting,” European Journal of Vascular and Endovascular Surgery, vol. 40, no. 2, pp. 274–281, 2010. View at Publisher · View at Google Scholar · View at Scopus
- L. Dong, H. R. Underhill, W. Yu et al., “Geometric and compositional appearance of atheroma in an angiographically normal carotid artery in patients with atherosclerosis,” American Journal of Neuroradiology, vol. 31, no. 2, pp. 311–316, 2010. View at Publisher · View at Google Scholar · View at Scopus
- N. Takaya, C. Yuan, B. Chu et al., “Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI—initial results,” Stroke, vol. 37, no. 3, pp. 818–823, 2006. View at Publisher · View at Google Scholar · View at Scopus
- N. Altaf, S. T. MacSweeney, J. Gladman, and D. P. Auer, “Carotid intraplaque hemorrhage predicts recurrent symptoms in patients with high-grade carotid stenosis,” Stroke, vol. 38, no. 5, pp. 1633–1635, 2007. View at Publisher · View at Google Scholar · View at Scopus
- N. Altaf, L. Daniels, P. S. Morgan et al., “Detection of intraplaque hemorrhage by magnetic resonance imaging in symptomatic patients with mild to moderate carotid stenosis predicts recurrent neurological events,” Journal of Vascular Surgery, vol. 47, no. 2, pp. 337–342, 2008. View at Publisher · View at Google Scholar · View at Scopus
- N. Singh, A. R. Moody, D. J. Gladstone et al., “Moderate carotid artery stenosis: MR imaging-depicted intraplaque hemorrhage predicts risk of cerebrovascular ischemic events in asymptomatic men,” Radiology, vol. 252, no. 2, pp. 502–508, 2009. View at Publisher · View at Google Scholar · View at Scopus
- Y. Kurosaki, K. Yoshida, H. Endo, M. Chin, and S. Yamagata, “Association between carotid atherosclerosis plaque with high signal intensity on T1-weighted imaging and subsequent ipsilateral ischemic events,” Neurosurgery, vol. 68, no. 1, pp. 62–67, 2011. View at Publisher · View at Google Scholar · View at Scopus
- U. Sadat, Z. Teng, V. E. Young et al., “Association between biomechanical structural stresses of atherosclerotic carotid plaques and subsequent ischaemic cerebrovascular events—a longitudinal in vivo magnetic resonance imaging-based finite element Study,” EJVES Extra, vol. 40, no. 4, pp. 485–491, 2010. View at Publisher · View at Google Scholar · View at Scopus
- F. D. Kolodgie, H. K. Gold, A. P. Burke et al., “Intraplaque hemorrhage and progression of coronary atheroma,” The New England Journal of Medicine, vol. 349, no. 24, pp. 2316–2325, 2003. View at Publisher · View at Google Scholar · View at Scopus
- R. Virmani, F. D. Kolodgie, A. P. Burke et al., “Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 10, pp. 2054–2061, 2005. View at Publisher · View at Google Scholar · View at Scopus
- A. V. Finn, M. Nakano, R. Polavarapu et al., “Hemoglobin directs macrophage differentiation and prevents foam cell formation in human atherosclerotic plaques,” Journal of the American College of Cardiology, vol. 59, no. 2, pp. 166–177, 2012. View at Publisher · View at Google Scholar · View at Scopus
- J. N. E. Redgrave, J. K. Lovett, P. J. Gallagher, and P. M. Rothwell, “Histological assessment of 526 symptomatic carotid plaques in relation to the nature and timing of ischemic symptoms: the Oxford plaque study,” Circulation, vol. 113, no. 19, pp. 2320–2328, 2006. View at Publisher · View at Google Scholar · View at Scopus
- A. R. Moody, R. E. Murphy, P. S. Morgan et al., “Characterization of complicated carotid plaque with magnetic resonance direct thrombus imaging in patients with cerebral ischemia,” Circulation, vol. 107, no. 24, pp. 3047–3052, 2003. View at Publisher · View at Google Scholar · View at Scopus
- B. Chu, A. Kampschulte, M. S. Ferguson et al., “Hemorrhage in the atherosclerotic carotid plaque: a high-resolution MRI study,” Stroke, vol. 35, no. 5, pp. 1079–1084, 2004. View at Publisher · View at Google Scholar · View at Scopus
- A. Kampschulte, M. S. Ferguson, W. S. Kerwin et al., “Differentiation of intraplaque versus juxtaluminal hemorrhage/thrombus in advanced human carotid atherosclerotic lesions by in vivo magnetic resonance imaging,” Circulation, vol. 110, no. 20, pp. 3239–3244, 2004. View at Publisher · View at Google Scholar · View at Scopus
- R. Bitar, A. R. Moody, G. Leung et al., “In vivo 3D high-spatial-resolution MR imaging of intraplaque hemorrhage,” Radiology, vol. 249, no. 1, pp. 259–267, 2008. View at Publisher · View at Google Scholar · View at Scopus
- J. Y. Yoo, H. C. Yeon, Y. Ko et al., “High signal intensity halo around the carotid artery on maximum intensity projection images of time-of-flight MR angiography: a new sign for intraplaque hemorrhage,” Journal of Magnetic Resonance Imaging, vol. 27, no. 6, pp. 1341–1346, 2008. View at Publisher · View at Google Scholar · View at Scopus
- H. Ota, V. L. Yarnykh, M. S. Ferguson et al., “Carotid intraplaque hemorrhage imaging at 3.0-T MR imaging: comparison of the diagnostic performance of three T1-weighted sequences,” Radiology, vol. 254, no. 2, pp. 551–563, 2010. View at Publisher · View at Google Scholar · View at Scopus
- Y. Qiao, M. Etesami, S. Malhotra et al., “Identification of intraplaque hemorrhage on MR angiography images: a comparison of contrast-enhanced mask and time-of-flight techniques,” American Journal of Neuroradiology, vol. 32, no. 3, pp. 454–459, 2011. View at Publisher · View at Google Scholar · View at Scopus
- C. Yuan, L. M. Mitsumori, M. S. Ferguson et al., “In vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaques,” Circulation, vol. 104, no. 17, pp. 2051–2056, 2001. View at Scopus
- A. R. Moody, J. G. Pollock, A. R. O'Connor, and M. Bagnall, “Lower-limb deep venous thrombosis: direct MR imaging of the thrombus,” Radiology, vol. 209, no. 2, pp. 349–355, 1998. View at Scopus
- J. Wang, M. S. Ferguson, N. Balu, C. Yuan, T. S. Hatsukami, and P. Bornert, “Improved carotid intraplaque hemorrhage imaging using a slab-selective phase-sensitive inversion-recovery (SPI) sequence,” Magnetic Resonance in Medicine, vol. 64, no. 5, pp. 1332–1340, 2010. View at Publisher · View at Google Scholar · View at Scopus
- J. Wang, P. Börnert, H. Zhao, et al., “Simultaneous noncontrast angiography and intraPlaque hemorrhage (SNAP) imaging for carotid atherosclerotic disease evaluation,” Magnetic Resonance in Medicine. In press. View at Publisher · View at Google Scholar
- A. Halliday, A. Mansfield, J. Marro, et al., “Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial,” The Lancet, vol. 363, no. 9420, pp. 1491–1502, 2004. View at Publisher · View at Google Scholar · View at Scopus
- H. J. M. Barnett, D. W. Taylor, M. Eliasziw et al., “Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis,” The New England Journal of Medicine, vol. 339, no. 20, pp. 1415–1425, 1998. View at Publisher · View at Google Scholar · View at Scopus
- J. M. U-King-Im, T. Y. Tang, A. Patterson et al., “Characterisation of carotid atheroma in symptomatic and asymptomatic patients using high resolution MRI,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 79, no. 8, pp. 905–912, 2008. View at Publisher · View at Google Scholar · View at Scopus
- U. Sadat, R. A. Weerakkody, D. J. Bowden et al., “Utility of high resolution MR imaging to assess carotid plaque morphology: a comparison of acute symptomatic, recently symptomatic and asymptomatic patients with carotid artery disease,” Atherosclerosis, vol. 207, no. 2, pp. 434–439, 2009. View at Publisher · View at Google Scholar · View at Scopus
- J. K. DeMarco, H. Ota, H. R. Underhill et al., “MR carotid plaque imaging and contrast-enhanced MR angiography identifies lesions associated with recent ipsilateral thromboembolic symptoms: an in vivo study at 3T,” American Journal of Neuroradiology, vol. 31, no. 8, pp. 1395–1402, 2010. View at Publisher · View at Google Scholar · View at Scopus
- Y. Qiao, M. Etesami, B. C. Astor, S. R. Zeiler, H. H. Trout III, and B. A. Wasserman, “Carotid plaque neovascularization and hemorrhage detected by MR imaging are associated with recent cerebrovascular ischemic events,” American Journal of Neuroradiology, vol. 33, no. 4, pp. 755–760, 2012. View at Publisher · View at Google Scholar · View at Scopus
- T. Saam, J. Cai, L. Ma et al., “Comparison of symptomatic and asymptomatic atherosclerotic carotid plaque features with in vivo MR imaging,” Radiology, vol. 240, no. 2, pp. 464–472, 2006. View at Publisher · View at Google Scholar · View at Scopus
- R. E. Murphy, A. R. Moody, P. S. Morgan et al., “Prevalence of complicated carotid atheroma as detected by magnetic resonance direct thrombus imaging in patients with suspected carotid artery stenosis and previous acute cerebral ischemia,” Circulation, vol. 107, no. 24, pp. 3053–3058, 2003. View at Publisher · View at Google Scholar · View at Scopus
- J. S. McNally, S.-E. Kim, H.-C. Yoon et al., “Carotid magnetization-prepared rapid acquisition with gradient-echo signal is associated with acute territorial cerebral ischemic events detected by diffusion-weighted MRI,” Circulation, vol. 5, no. 3, pp. 376–382, 2012. View at Publisher · View at Google Scholar · View at Scopus
- H. R. Underhill, C. Yuan, V. L. Yarnykh et al., “Predictors of surface disruption with MR imaging in asymptomatic carotid artery stenosis,” American Journal of Neuroradiology, vol. 31, no. 3, pp. 487–493, 2010. View at Publisher · View at Google Scholar · View at Scopus
- N. Takaya, C. Yuan, B. Chu et al., “Presence of intraplaque hemorrhage stimulates progression of carotid atherosclerotic plaques: a high-resolution magnetic resonance imaging study,” Circulation, vol. 111, no. 21, pp. 2768–2775, 2005. View at Publisher · View at Google Scholar · View at Scopus
- H. R. Underhill, C. Yuan, V. L. Yarnykh et al., “Arterial remodeling in the subclinical carotid artery: a natural history study,” Journal of the American College of Cardiology, vol. 2, no. 12, pp. 1381–1389, 2009. View at Publisher · View at Google Scholar · View at Scopus
- K. Yamada, S. Yoshimura, M. Kawasaki et al., “Embolic complications after carotid artery stenting or carotid endarterectomy are associated with tissue characteristics of carotid plaques evaluated by magnetic resonance imaging,” Atherosclerosis, vol. 215, no. 2, pp. 399–404, 2011. View at Publisher · View at Google Scholar · View at Scopus
- S. Yoshimura, K. Yamada, M. Kawasaki et al., “High-intensity signal on time-of-flight magnetic resonance angiography indicates carotid plaques at high risk for cerebral embolism during stenting,” Stroke, vol. 42, no. 11, pp. 3132–3137, 2011. View at Publisher · View at Google Scholar · View at Scopus
- S. Glagov, E. Weisenberg, and C. K. Zarins, “Compensatory enlargement of human atherosclerotic coronary arteries,” The New England Journal of Medicine, vol. 316, no. 22, pp. 1371–1375, 1987. View at Scopus
- Y. Luo, N. Polissar, C. Han et al., “Accuracy and uniqueness of three in vivo measurements of atherosclerotic carotid plaque morphology with black blood MRI,” Magnetic Resonance in Medicine, vol. 50, no. 1, pp. 75–82, 2003. View at Publisher · View at Google Scholar · View at Scopus
- X. Zhao, H. R. Underhill, Q. Zhao et al., “Discriminating carotid atherosclerotic lesion severity by luminal stenosis and plaque burden: a comparison utilizing high-resolution magnetic resonance imaging at 3.0 tesla,” Stroke, vol. 42, no. 2, pp. 347–353, 2011. View at Publisher · View at Google Scholar · View at Scopus
- T. Saam, W. S. Kerwin, B. Chu et al., “Sample size calculation for clinical trials using magnetic resonance imaging for the quantitative assessment of carotid atherosclerosis,” Journal of Cardiovascular Magnetic Resonance, vol. 7, no. 5, pp. 799–808, 2005. View at Publisher · View at Google Scholar · View at Scopus
- A. Varghese, L. A. Crowe, R. H. Mohiaddin et al., “Interstudy reproducibility of three-dimensional volume-selective fast spin echo magnetic resonance for quantifying carotid artery wall volume,” Journal of Magnetic Resonance Imaging, vol. 21, no. 2, pp. 187–191, 2005. View at Publisher · View at Google Scholar · View at Scopus
- M. A. Syed, J. N. Oshinski, C. Kitchen, A. Ali, R. J. Charnigo, and A. A. Quyyumi, “Variability of carotid artery measurements on 3-Tesla MRI and its impact on sample size calculation for clinical research,” International Journal of Cardiovascular Imaging, vol. 25, no. 6, pp. 581–589, 2009. View at Publisher · View at Google Scholar · View at Scopus
- F. Li, V. L. Yarnykh, T. S. Hatsukami et al., “Scan-rescan reproducibility of carotid atherosclerotic plaque morphology and tissue composition measurements using multicontrast MRI at 3T,” Journal of Magnetic Resonance Imaging, vol. 31, no. 1, pp. 168–176, 2010. View at Publisher · View at Google Scholar · View at Scopus
- B. A. Wasserman, B. C. Astor, A. Richey Sharrett, C. Swingen, and D. Catellier, “MRI measurements of carotid plaque in the atherosclerosis risk in communities (ARIC) study: methods, reliability and descriptive statistics,” Journal of Magnetic Resonance Imaging, vol. 31, no. 2, pp. 406–415, 2010. View at Publisher · View at Google Scholar · View at Scopus
- R. Van't Klooster, P. J. H. De Koning, R. A. Dehnavi et al., “Automatic lumen and outer wall segmentation of the carotid artery using deformable three-dimensional models in MR angiography and vessel wall images,” Journal of Magnetic Resonance Imaging, vol. 35, no. 1, pp. 156–165, 2012. View at Publisher · View at Google Scholar · View at Scopus
- T. Saam, C. Yuan, B. Chu et al., “Predictors of carotid atherosclerotic plaque progression as measured by noninvasive magnetic resonance imaging,” Atherosclerosis, vol. 194, no. 2, pp. e34–e42, 2007. View at Publisher · View at Google Scholar · View at Scopus
- V. L. Yarnykh and C. Yuan, “Multislice double inversion-recovery black-blood imaging with simultaneous slice reinversion,” Journal of Magnetic Resonance Imaging, vol. 17, no. 4, pp. 478–483, 2003. View at Publisher · View at Google Scholar · View at Scopus
- S. Zhang, T. S. Hatsukami, N. L. Polissar, C. Han, and C. Yuan, “Comparison of carotid vessel wall area measurements using three different contrast-weighted black blood mr imaging techniques,” Magnetic Resonance Imaging, vol. 19, no. 6, pp. 795–802, 2001. View at Publisher · View at Google Scholar · View at Scopus
- D. A. Steinman and B. K. Rutt, “On the nature and reduction of plaque-mimicking flow artifacts in black blood MRI of the carotid bifurcation,” Magnetic Resonance in Medicine, vol. 39, no. 4, pp. 635–641, 1998. View at Publisher · View at Google Scholar · View at Scopus
- L. Antiga, B. A. Wasserman, and D. A. Steinman, “On the overestimation of early wall thickening at the carotid bulb by black blood MRI, with implications for coronary and vulnerable plaque imaging,” Magnetic Resonance in Medicine, vol. 60, no. 5, pp. 1020–1028, 2008. View at Publisher · View at Google Scholar · View at Scopus
- N. Balu, V. L. Yarnykh, B. Chu, J. Wang, T. Hatsukami, and C. Yuan, “Carotid plaque assessment using fast 3D isotropic resolution black-blood MRI,” Magnetic Resonance in Medicine, vol. 65, no. 3, pp. 627–637, 2011. View at Publisher · View at Google Scholar · View at Scopus
- I. Koktzoglou and D. Li, “Diffusion-prepared segmented steady-state free precession: application to 3D black-blood cardiovascular magnetic resonance of the thoracic aorta and carotid artery walls,” Journal of Cardiovascular Magnetic Resonance, vol. 9, no. 1, pp. 33–42, 2007. View at Publisher · View at Google Scholar · View at Scopus
- G. Mihai, Y. C. Chung, M. Kariisa, S. V. Raman, O. P. Simonetti, and S. Rajagopalan, “Initial feasibility of a multi-station high resolution three-dimensional dark blood angiography protocol for the assessment of peripheral arterial disease,” Journal of Magnetic Resonance Imaging, vol. 30, no. 4, pp. 785–793, 2009. View at Publisher · View at Google Scholar · View at Scopus
- C. Yuan, E. Lin, J. Millard, and J. N. Hwang, “Closed contour edge detection of blood vessel lumen and outer wall boundaries in black-blood MR images,” Magnetic Resonance Imaging, vol. 17, no. 2, pp. 257–266, 1999. View at Publisher · View at Google Scholar · View at Scopus
- H. M. Ladak, J. B. Thomas, J. R. Mitchell, B. K. Rutt, and D. A. Steinman, “A semi-automatic technique for measurement of arterial wall from black blood MRI,” Medical Physics, vol. 28, no. 6, pp. 1098–1107, 2001. View at Scopus
- C. Han, W. S. Kerwin, T. S. Hatsukami, J. N. Hwang, and C. Yuan, “Detecting objects in image sequences using rule-based control in an active contour model,” IEEE Transactions on Biomedical Engineering, vol. 50, no. 6, pp. 705–710, 2003. View at Publisher · View at Google Scholar · View at Scopus
- I. M. Adame, R. J. Van Der Geest, B. A. Wasserman, M. A. Mohamed, J. H. C. Reiber, and B. P. F. Lelieveldt, “Automatic segmentation and plaque characterization in atherosclerotic carotid artery MR images,” Magnetic Resonance Materials in Physics, Biology and Medicine, vol. 16, no. 5, pp. 227–234, 2004. View at Publisher · View at Google Scholar · View at Scopus
- W. Kerwin, D. Xu, F. Liu et al., “Magnetic resonance imaging of carotid atherosclerosis: plaque analysis,” Topics in Magnetic Resonance Imaging, vol. 18, no. 5, pp. 371–378, 2007. View at Publisher · View at Google Scholar · View at Scopus
- V. Mani, P. Muntner, S. S. Gidding et al., “Cardiovascular magnetic resonance parameters of atherosclerotic plaque burden improve discrimination of prior major adverse cardiovascular events,” Journal of Cardiovascular Magnetic Resonance, vol. 11, no. 1, article 10, 2009. View at Publisher · View at Google Scholar · View at Scopus
- R. Corti, V. Fuster, Z. A. Fayad et al., “Lipid lowering by simvastatin induces regression of human atherosclerotic lesions: two years' follow-up by high-resolution noninvasive magnetic resonance imaging,” Circulation, vol. 106, no. 23, pp. 2884–2887, 2002. View at Publisher · View at Google Scholar · View at Scopus
- H. R. Underhill, C. Yuan, X. Q. Zhao et al., “Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: a high-resolution magnetic resonance imaging trial,” American Heart Journal, vol. 155, no. 3, pp. 584.e1–584.e8, 2008. View at Publisher · View at Google Scholar · View at Scopus
- J. M. S. Lee, M. D. Robson, L. M. Yu et al., “Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: a randomized, placebo-controlled, magnetic resonance imaging study,” Journal of the American College of Cardiology, vol. 54, no. 19, pp. 1787–1794, 2009. View at Publisher · View at Google Scholar · View at Scopus
- X.-Q. Zhao, L. Dong, T. Hatsukami, et al., “MR imaging of carotid plaque composition during lipid-lowering therapy: a prospective assessment of effect and time course,” Journal of the American College of Cardiology, vol. 4, no. 9, pp. 977–986, 2011. View at Publisher · View at Google Scholar · View at Scopus
- J. N. Redgrave, P. Gallagher, J. K. Lovett, and P. M. Rothwell, “Critical cap thickness and rupture in symptomatic carotid plaques: the oxford plaque study,” Stroke, vol. 39, no. 6, pp. 1722–1729, 2008. View at Publisher · View at Google Scholar · View at Scopus
- R. Virmani, E. R. Ladich, A. P. Burke, and F. D. Kolodgie, “Histopathology of carotid atherosclerotic disease,” Neurosurgery, vol. 59, no. 5, pp. S219–S3, 2006. View at Scopus
- R. Virmani, F. D. Kolodgie, A. P. Burke, A. Farb, and S. M. Schwartz, “Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 20, no. 5, pp. 1262–1275, 2000. View at Scopus
- T. Saam, M. S. Ferguson, V. L. Yarnykh et al., “Quantitative evaluation of carotid plaque composition by in vivo MRI,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 1, pp. 234–239, 2005. View at Publisher · View at Google Scholar · View at Scopus
- J. Cai, T. S. Hatsukami, M. S. Ferguson et al., “In vivo quantitative measurement of intact fibrous cap and lipid-rich necrotic core size in atherosclerotic carotid plaque: comparison of high-resolution, contrast-enhanced magnetic resonance imaging and histology,” Circulation, vol. 112, no. 22, pp. 3437–3444, 2005. View at Publisher · View at Google Scholar · View at Scopus
- N. Takaya, J. Cai, M. S. Ferguson et al., “Intra- and interreader reproducibility of magnetic resonance imaging for quantifying the lipid-rich necrotic core is improved with gadolinium contrast enhancement,” Journal of Magnetic Resonance Imaging, vol. 24, no. 1, pp. 203–210, 2006. View at Publisher · View at Google Scholar · View at Scopus
- F. Liu, D. Xu, M. S. Ferguson et al., “Automated in vivo segmentation of carotid plaque MRI with morphology-enhanced probability maps,” Magnetic Resonance in Medicine, vol. 55, no. 3, pp. 659–668, 2006. View at Publisher · View at Google Scholar · View at Scopus
- C. Yuan, W. S. Kerwin, M. S. Ferguson et al., “Contrast-enhanced high resolution MRI for atherosclerotic carotid artery tissue characterization,” Journal of Magnetic Resonance Imaging, vol. 15, no. 1, pp. 62–67, 2002. View at Publisher · View at Google Scholar · View at Scopus
- B. A. Wasserman, W. I. Smith, H. H. Trout, R. O. Cannon, R. S. Balaban, and A. E. Arai, “Carotid artery atherosclerosis: in vivo morphologic characterization with gadolinium-enhanced double-oblique MR imaging—initial results,” Radiology, vol. 223, no. 2, pp. 566–573, 2002. View at Scopus
- W. S. Kerwin, F. Liu, V. Yarnykh et al., “Signal features of the atherosclerotic plaque at 3.0 Tesla versus 1.5 Tesla: impact on automatic classification,” Journal of Magnetic Resonance Imaging, vol. 28, no. 4, pp. 987–995, 2008. View at Publisher · View at Google Scholar · View at Scopus
- W. Liu, N. Balu, J. Sun et al., “Segmentation of carotid plaque using multicontrast 3D gradient echo MRI,” Journal of Magnetic Resonance Imaging, vol. 35, no. 4, pp. 812–819, 2012. View at Publisher · View at Google Scholar · View at Scopus
- B. C. Te Boekhorst, R. Van 'T Klooster, S. M. Bovens et al., “Evaluation of multicontrast MRI including fat suppression and inversion recovery spin echo for identification of intra-plaque hemorrhage and lipid core in human carotid plaque using the mahalanobis distance measure,” Magnetic Resonance in Medicine, vol. 67, no. 6, pp. 1764–1775, 2012. View at Publisher · View at Google Scholar · View at Scopus
- C. Karmonik, P. Basto, K. Vickers et al., “Quantitative segmentation of principal carotid atherosclerotic lesion components by feature space analysis based on multicontrast MRI at 1.5 T,” IEEE Transactions on Biomedical Engineering, vol. 56, no. 2, pp. 352–360, 2009. View at Publisher · View at Google Scholar · View at Scopus
- J. M. A. Hofman, W. J. Branderhorst, H. M. M. Ten Eikelder et al., “Quantification of atherosclerotic plaque components using in vivo MRI and supervised classifiers,” Magnetic Resonance in Medicine, vol. 55, no. 4, pp. 790–799, 2006. View at Publisher · View at Google Scholar · View at Scopus
- D. Tang, C. Yang, J. Zheng et al., “3D MRI-based multicomponent FSI models for atherosclerotic plaques,” Annals of Biomedical Engineering, vol. 32, no. 7, pp. 947–960, 2004. View at Publisher · View at Google Scholar · View at Scopus
- S. A. Kock, J. V. Nygaard, N. Eldrup et al., “Mechanical stresses in carotid plaques using MRI-based fluid-structure interaction models,” Journal of Biomechanics, vol. 41, no. 8, pp. 1651–1658, 2008. View at Publisher · View at Google Scholar · View at Scopus
- H. Gao, Q. Long, M. Graves, J. H. Gillard, and Z. Y. Li, “Carotid arterial plaque stress analysis using fluid-structure interactive simulation based on in-vivo magnetic resonance images of four patients,” Journal of Biomechanics, vol. 42, no. 10, pp. 1416–1423, 2009. View at Publisher · View at Google Scholar · View at Scopus
- C. Yuan, S. X. Zhang, N. L. Polissar et al., “Identification of fibrous cap rupture with magnetic resonance imaging is highly associated with recent transient ischemic attack or stroke,” Circulation, vol. 105, no. 2, pp. 181–185, 2002. View at Publisher · View at Google Scholar · View at Scopus
- V. C. Cappendijk, A. G. H. Kessels, S. Heeneman et al., “Comparison of lipid-rich necrotic core size in symptomatic and asymptomatic carotid atherosclerotic plaque: initial results,” Journal of Magnetic Resonance Imaging, vol. 27, no. 6, pp. 1356–1361, 2008. View at Publisher · View at Google Scholar · View at Scopus
- H. Gao, Q. Long, S. Kumar Das et al., “Study of carotid arterial plaque stress for symptomatic and asymptomatic patients,” Journal of Biomechanics, vol. 44, no. 14, pp. 2551–2557, 2011. View at Publisher · View at Google Scholar · View at Scopus
- M. Cuchel and D. J. Rader, “Macrophage reverse cholesterol transport: key to the regression of atherosclerosis?” Circulation, vol. 113, no. 21, pp. 2548–2555, 2006. View at Publisher · View at Google Scholar · View at Scopus
- A. C. Newby, “Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 12, pp. 2108–2114, 2008. View at Publisher · View at Google Scholar · View at Scopus
- S. Jander, M. Sitzer, R. Schumann et al., “Inflammation in high-grade carotid stenosis: a possible role for macrophages and T cells in plaque destabilization,” Stroke, vol. 29, no. 8, pp. 1625–1630, 1998. View at Scopus
- T. Husain, C. R. Abbott, D. J. A. Scott, and M. J. Gough, “Macrophage accumulation within the cap of carotid atherosclerotic plaques is associated with the onset of cerebral ischemic events,” Journal of Vascular Surgery, vol. 30, no. 2, pp. 269–276, 1999. View at Publisher · View at Google Scholar · View at Scopus
- R. Mofidi, T. B. Crotty, P. McCarthy, S. J. Sheehan, D. Mehigan, and T. V. Keaveny, “Association between plaque instability, angiogenesis and symptomatic carotid occlusive disease,” British Journal of Surgery, vol. 88, no. 7, pp. 945–950, 2001. View at Publisher · View at Google Scholar · View at Scopus
- M. J. McCarthy, I. M. Loftus, M. M. Thompson et al., “Angiogenesis and the atherosclerotic carotid plaque: an association between symptomatology and plaque morphology,” Journal of Vascular Surgery, vol. 30, no. 2, pp. 261–268, 1999. View at Publisher · View at Google Scholar · View at Scopus
- E. Lancelot, V. Amirbekian, I. Brigger et al., “Evaluation of matrix metalloproteinases in atherosclerosis using a novel noninvasive imaging approach,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 3, pp. 425–432, 2008. View at Publisher · View at Google Scholar · View at Scopus
- M. J. Lipinski, J. C. Frias, V. Amirbekian et al., “Macrophage-specific lipid-based nanoparticles improve cardiac magnetic resonance detection and characterization of human atherosclerosis,” Journal of the American College of Cardiology, vol. 2, no. 5, pp. 637–647, 2009. View at Publisher · View at Google Scholar · View at Scopus
- P. M. Winter, A. M. Morawski, S. D. Caruthers et al., “Molecular imaging of angiogenesis in early-stage atherosclerosis with alpha(v)beta3-integrin-targeted nanoparticles,” Circulation, vol. 108, no. 18, pp. 2270–2274, 2003. View at Publisher · View at Google Scholar · View at Scopus
- M. E. Kool, V. C. Cappendijk, K. B. J. M. Cleutjens et al., “Accumulation of ultrasmall superparamagnetic particles of iron oxide in human atherosclerotic plaques can be detected by in vivo magnetic resonance imaging,” Circulation, vol. 107, no. 19, pp. 2453–2458, 2003. View at Publisher · View at Google Scholar · View at Scopus
- R. A. Trivedi, J. M. U-King-Im, M. J. Graves et al., “In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI,” Stroke, vol. 35, no. 7, pp. 1631–1635, 2004. View at Publisher · View at Google Scholar · View at Scopus
- A. J. Patterson, T. Y. Tang, M. J. Graves, K. H. Müller, and J. H. Gillard, “In vivo carotid plaque MRI using quantitative measurements with ultrasmall superparamagnetic iron oxide particles: a dose-response study to statin therapy,” NMR in Biomedicine, vol. 24, no. 1, pp. 89–95, 2011. View at Publisher · View at Google Scholar · View at Scopus
- T. Y. Tang, S. P. S. Howarth, S. R. Miller et al., “Correlation of carotid atheromatous plaque inflammation using USPIO-enhanced MR imaging with degree of luminal Stenosis,” Stroke, vol. 39, no. 7, pp. 2144–2147, 2008. View at Publisher · View at Google Scholar · View at Scopus
- S. P. S. Howarth, T. Y. Tang, R. Trivedi et al., “Utility of USPIO-enhanced MR imaging to identify inflammation and the fibrous cap: a comparison of symptomatic and asymptomatic individuals,” European Journal of Radiology, vol. 70, no. 3, pp. 555–560, 2009. View at Publisher · View at Google Scholar · View at Scopus
- T. Y. Tang, S. P. S. Howarth, S. R. Miller et al., “Comparison of the inflammatory burden of truly asymptomatic carotid atheroma with atherosclerotic plaques contralateral to symptomatic carotid stenosis: an ultra small superparamagnetic iron oxide enhanced magnetic resonance study,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 78, no. 12, pp. 1337–1343, 2007. View at Publisher · View at Google Scholar · View at Scopus
- W. Kerwin, A. Hooker, M. Spilker et al., “Quantitative magnetic resonance imaging analysis of neovasculature volume in carotid atherosclerotic plaque,” Circulation, vol. 107, no. 6, pp. 851–856, 2003. View at Publisher · View at Google Scholar · View at Scopus
- W. S. Kerwin, K. D. O'Brien, M. S. Ferguson, N. Polissar, T. S. Hatsukami, and C. Yuan, “Inflammation in carotid atherosclerotic plaque: a dynamic contrast-enhanced MR imaging study,” Radiology, vol. 241, no. 2, pp. 459–468, 2006. View at Publisher · View at Google Scholar · View at Scopus
- W. S. Kerwin, M. Oikawa, C. Yuan, G. P. Jarvik, and T. S. Hatsukami, “MR imaging of adventitial vasa vasorum in carotid atherosclerosis,” Magnetic Resonance in Medicine, vol. 59, no. 3, pp. 507–514, 2008. View at Publisher · View at Google Scholar · View at Scopus
- H. Chen, J. Cai, X. Zhao et al., “Localized measurement of atherosclerotic plaque inflammatory burden with dynamic contrast-enhanced MRI,” Magnetic Resonance in Medicine, vol. 64, no. 2, pp. 567–573, 2010. View at Publisher · View at Google Scholar · View at Scopus
- S. M. Grundy, G. J. Balady, M. H. Criqui et al., “Primary prevention of coronary heart disease: guidance from Framingham: a statement for healthcare professionals from the AHA task force on risk reduction,” Circulation, vol. 97, no. 18, pp. 1876–1887, 1998. View at Scopus
- H. C. Stary, A. B. Chandler, R. E. Dinsmore et al., “A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis: a report from the Committee on Vascular Lesions of the council on arteriosclerosis, American heart association,” Circulation, vol. 92, no. 5, pp. 1355–1374, 1995. View at Scopus
- J. M. Cai, T. S. Hatsukami, M. S. Ferguson, R. Small, N. L. Polissar, and C. Yuan, “Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging,” Circulation, vol. 106, no. 11, pp. 1368–1373, 2002. View at Publisher · View at Google Scholar · View at Scopus
- A. C. Lindsay, L. Biasiolli, J. M. S. Lee et al., “Plaque features associated with increased cerebral infarction after minor stroke and TIA: a prospective, case-control, 3-T carotid artery MR imaging study,” Journal of the American College of Cardiology, vol. 5, no. 4, pp. 388–396, 2012. View at Publisher · View at Google Scholar · View at Scopus
- T. M. Freilinger, A. Schindler, C. Schmidt et al., “Prevalence of nonstenosing, complicated atherosclerotic plaques in cryptogenic stroke,” Journal of the American College of Cardiology, vol. 5, no. 4, pp. 397–405, 2012. View at Publisher · View at Google Scholar · View at Scopus
- J. P. Parmar, W. J. Rogers, J. P. Mugler et al., “Magnetic resonance imaging of carotid atherosclerotic plaque in clinically suspected acute transient ischemic attack and acute ischemic stroke,” Circulation, vol. 122, no. 20, pp. 2031–2038, 2010. View at Publisher · View at Google Scholar · View at Scopus
- L. Gury-Paquet, A. Millon, F. Salami, et al., “Carotid plaque high-resolution MRI at 3 T: evaluation of a new imaging score for symptomatic plaque assessment,” Magnetic Resonance Imaging, vol. 30, no. 10, pp. 1424–1431, 2012. View at Publisher · View at Google Scholar
- H. R. Underhill, T. S. Hatsukami, J. Cai et al., “A noninvasive imaging approach to assess plaque severity: the carotid atherosclerosis score,” American Journal of Neuroradiology, vol. 31, no. 6, pp. 1068–1075, 2010. View at Publisher · View at Google Scholar · View at Scopus
- R. L. Sacco, J. H. Ellenberg, J. P. Mohr et al., “Infarcts of undetermined cause: the NINCDS Stroke Data Bank,” Annals of Neurology, vol. 25, no. 4, pp. 382–390, 1989. View at Scopus