Table 6: Prevalence of cardiac ion channel-related mutations in SIDS cohorts‡.

Number of SIDS cases   Gene Total with mutation Functionally significant related genes        SCN5A 542 28 (5.2%) 26 (4.8%)  SCN1B 292 0 0  SCN1Bb 292 1 (0.3%) 1 (0.3%)  SCN2B 292 0 0  SCN3B 292 2 (0.7%) 2 (0.7%)  SCN4B 292 1 (0.3%) 1 (0.3%)  CAV3 335 6 (1.8%) 5 (1.5%)  GPD1-L 221 2 (0.9%) 2 (0.9%)  SNTA1 292 8 (2.7%) 3 (1.0%) related genes        KCND3 292 1 (0.3%) 0 related genes        KCNQ1 409 9 (2.2%) 4 (1.0%)  KCNE1 367 1 (0.3%) 0 related genes        KCNH2 409 8 (2.0%) 2 (0.5%)  KCNE2 367 2 (0.5%) 1 (0.3%) related genes        KCNJ2 201 0 0 related genes        KCNJ8 292 2 (0.7%) 2 (0.7%) Intracellular calcium cycling related genes        RYR2 134 2 (1.5%) 2 (1.5%) Gap junctional current related genes        GJA1 292 2 (0.7%) 1 (0.3%)

: ATP-sensitive potassium current; : inward rectifier potassium current; : rapid delayed rectifier potassium current; : slow delayed rectifier potassium current; : fast sodium current; : transient outward potassium current. ‡Based on data listed in Table 5.