Table 1: Oxidative disturbances found in SAMP8.

Target Modification References Protein carbonylation Increased [22–25] Lipid peroxidation Increased [22, 24, 26–28] Nucleic acid oxidation Increased [25, 29] Mn SOD Decreased activity [30] Glutathione reductase Not modified or decreased activity [22, 31] Catalase Not modified or decreased activity [22, 31] Glutamine synthetase Decreased activity [24] NO synthase Increased activity [32–34] Accumulation of 8-oxoguanine Increased [35]