Research Article

Generation of Constitutive Active ERK Mutants as Tools for Cancer Research in Zebrafish

Figure 4

Kinome profile clustering of embryos ectopically expressing ERK2WT, ERK2 triple mutant, and FGF8. Simplified representation of FGF-ERK signalling pathways to downstream specific target clusters (up). Clusters are based on a Bionavigator-based clustering algorithm, which groups peptides into clusters according to treatment-based response similarities (down). AKT is Protein Kinase B (PKB), PLCγ is Phospholipase Cγ.
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