International Scholarly Research Notices

Research Article

Generation of Constitutive Active ERK Mutants as Tools for Cancer Research in Zebrafish

Table 2

MAPK activating mutations.
OrganismGene nameActivating mutations Reference
RatrERK2/MAPK1 L73PS151D D319N Emrick et al. 2001 [24]
YeastFUS3 L63P D317N Hall et al. 1996 [25]
Drosophilarolled (rl)  D334N Brunner et al. 1994 [26]
ZebrafishzMAPK3/ERK1 L106P*S184D**D352N*** 
zMAPK1/ERK2 L84P*S162D**D330N*** 
Single mutant, containing L to P substitution.
**Double mutant, containing L to P and S to D substitutions.
***Triple mutants, containing L to P and S to D and D to N substitutions.