Volume 2012 (2012), Article ID 945198, 5 pages
Monitoring Organic Reactions by Micellar Electrokinetic Chromatography
1College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China
2Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, CAS, Dalian 116023, China
Received 19 December 2011; Accepted 29 January 2012
Academic Editors: E. Boselli, M. C. Monti, and A. I. Suarez
Copyright © 2012 Chun Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
A method was established to monitor organic reactions by micellar capillary electrokinetic chromatography (MEKC). After optimizing conditions such as the composition of the solvents, the surfactant, and the apparent pH (pH*) of the system, the method was utilized to analyze the reaction of glycidyl methacrylate (GMA) and allyl amine. The main products were identified in the electropherograms. The reaction procedure was monitored in real time. This method was found to have common applicability, being able to separate and detect nonaqueous soluble, nonionic, and low-UV-Vis absorbance compounds. It provides a rapid and low-cost way to understand organic reactions and to direct synthesis works.