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ISRN Neurology
Volume 2012 (2012), Article ID 134289, 11 pages
doi:10.5402/2012/134289
Review Article
Role of Vitamin D in Parkinson’s Disease
Vietnamese American Medical Research Foundation, Westminster, CA 92683, USA
Received 18 October 2011; Accepted 29 November 2011
Academic Editors: M.-C. Chartier-Harlin, S. Lorenzl, and G. Meco
Copyright © 2012 Khanh Lương and Lan Nguyễn. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- S. Abou-Raya, M. Helmii, and A. Abou-Raya, “Bone and mineral metabolism in older adults with Parkinson's disease,” Age and Ageing, vol. 38, no. 6, pp. 675–680, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- Y. Sato, M. Kaji, T. Tsuru, and K. Oizumi, “Risk factors for hip fracture among elderly patients with Parkinson's disease,” Journal of the Neurological Sciences, vol. 182, no. 2, pp. 89–93, 2001. View at Publisher · View at Google Scholar · View at Scopus
- Y. Sato, J. Iwamoto, and Y. Honda, “Amelioration of osteoporosis and hypovitaminosis D by sunlight exposure in Parkinson's disease,” Parkinsonism and Related Disorders, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- B. Lorefält, G. Toss, and A.-K. Granérus, “Bone mass in elderly patients with Parkinson's disease,” Acta Neurologica Scandinavica, vol. 116, no. 4, pp. 248–254, 2007. View at Publisher · View at Google Scholar · View at PubMed
- M. Invernizzi, S. Carda, G. S. Viscontini, and C. Cisari, “Osteoporosis in Parkinson's disease,” Parkinsonism and Related Disorders, vol. 15, no. 5, pp. 339–346, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- U. Fiszer, E. Mix, S. Fredrikson, V. Kostulas, and H. Link, “Parkinson's disease and immunological abnormalities: increase of HLA-DR expression on monocytes in cerebrospinal fluid and of CD45RO+ T cells in peripheral blood,” Acta Neurologica Scandinavica, vol. 90, no. 3, pp. 160–166, 1994. View at Scopus
- P. L. McGeer, S. Itagaki, B. E. Boyes, and E. G. McGeer, “Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains,” Neurology, vol. 38, no. 8, pp. 1285–1291, 1988. View at Scopus
- P. L. McGeer and S. E. G. Itagaki McGeer, “Expression of the histocompatibility glycoprotein HLA-DR in neurological disease,” Acta Neuropathologica, vol. 76, no. 6, pp. 550–557, 1988. View at Scopus
- N. Tokuda and R. B. Levy, “1,25-Dihydroxyvitamin D3 stimulates phagocytosis but suppresses HLA-DR and CD13 antigen expression in human mononuclear phagocytes,” Proceedings of the Society for Experimental Biology and Medicine, vol. 211, no. 3, pp. 244–250, 1996. View at Scopus
- N. Tokuda, N. Mizuki, M. Kasahara, and R. B. Levy, “1,25-dihydroxyvitamin D3 down-regulation of HLA-DR on human peripheral blood monocytes,” Immunology, vol. 75, no. 2, pp. 349–354, 1992. View at Scopus
- K. Tamaki, A. Saitoh, and Y. Kubota, “1,25-Dihydroxyvitamin D3 decreases the interferon-γ (IFN-γ) induced HLA-DR expression but not intercellular adhesion molecule 1 (ICAM-1) on human keratinocytes,” Regional Immunology, vol. 3, no. 5, pp. 223–227, 1990.
- T. Tone, H. Eto, K. Katsuoka, K. Nishioka, and S. Nishiyama, “Suppression of gamma-interferon induced HLA-DR antigen expression on normal and transformed keratinocytes by 1,25 (OH)2 vitamin D3,” The Japanese Journal of Dermatology, vol. 101, no. 5, pp. 519–525, 1991. View at Scopus
- D. W. Eyles, S. Smith, R. Kinobe, M. Hewison, and J. J. McGrath, “Distribution of the Vitamin D receptor and 1α-hydroxylase in human brain,” Journal of Chemical Neuroanatomy, vol. 29, no. 1, pp. 21–30, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- T. H. J. Burne, J. J. McGrath, D. W. Eyles, and A. Mackay-Sim, “Behavioural characterization of Vitamin D receptor knockout mice,” Behavioural Brain Research, vol. 157, no. 2, pp. 299–308, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- C. R. Scherzer, A. C. Eklund, L. J. Morse et al., “Molecular markers of early Parkinson's disease based on gene expression in blood,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 3, pp. 955–960, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J. S. Kim, Y. I. Kim, C. Song et al., “Association of vitamin D receptor gene polymorphism and Parkinson's disease in Koreans,” Journal of Korean Medical Science, vol. 20, no. 3, pp. 495–498, 2005. View at Scopus
- M. W. Butler, A. Burt, T. L. Edwards et al., “Vitamin D receptor gene as a candidate gene for Parkinson disease,” Annals of Human Genetics, vol. 75, no. 2, pp. 201–210, 2011. View at Publisher · View at Google Scholar · View at PubMed
- M. Stefanovic, E. Topic, A. M. Ivanisevic, M. Relja, and M. Korsic, “Genotyping of CYP2D6 in Parkinson's disease,” Clinical Chemistry and Laboratory Medicine, vol. 38, no. 9, pp. 929–934, 2000. View at Scopus
- M. Singh, V. K. Khanna, R. Shukla, and D. Parmar, “Association of polymorphism in cytochrome P450 2D6 and N-acetyltransferase-2 with Parkinson's disease,” Disease Markers, vol. 28, no. 2, pp. 87–93, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- S. J. McCann, S. M. Pond, K. M. James, and D. G. Le Couteur, “The association between polymorphisms in the cytochrome P-450 2D6 gene and Parkinson's disease: a case-control study and meta-analysis,” Journal of the Neurological Sciences, vol. 153, no. 1, pp. 50–53, 1997. View at Publisher · View at Google Scholar · View at Scopus
- S. L. Ho, M. H. W. Kung, L. S. W. Li, I. J. Lauder, and D. B. Ramsden, “Cytochrome P4502D6 (debrisoquine 4-hydroxylase) and Parkinson's disease in Chinese and Caucasians,” European Journal of Neurology, vol. 6, no. 3, pp. 323–329, 1999. View at Scopus
- S. I. Woo, J. W. Kim, H. G. Seo et al., “CYP2D6*4 polymorphism is not associated with Parkinson's disease and has no protective role against Alzheimer's disease in the Korean population,” Psychiatry and Clinical Neurosciences, vol. 55, no. 4, pp. 373–377, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- U. M. Zanger, S. Raimundo, and M. Eichelbaum, “Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 369, no. 1, pp. 23–37, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- S. Singh, K. Singh, D. K. Patel et al., “The expression of cyp2d22, an ortholog of human cyp2d6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinson's disease phenotype and nicotine-mediated neuroprotection,” Rejuvenation Research, vol. 12, no. 3, pp. 185–197, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- C. J. Lin, A. Dardis, S. D. Wijesuriya, M. A. Abdullah, S. J. Casella, and W. L. Miller, “Lack of mutations in CYP2D6 and CYP27 in patients with apparent deficiency of vitamin D 25-hydroxylase,” Molecular Genetics and Metabolism, vol. 80, no. 4, pp. 469–472, 2003. View at Publisher · View at Google Scholar · View at Scopus
- S. Shojaee, F. Sina, S. S. Banihosseini et al., “Genome-wide linkage analysis of a parkinsonian-pyramidal syndrome pedigree by 500 K SNP arrays,” American Journal of Human Genetics, vol. 82, no. 6, pp. 1375–1384, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- K. Wilhelmsen, D. Mirel, K. Marder et al., “Is there a genetic susceptibility locus for Parkinson's disease on chromosome 22q13?” Annals of Neurology, vol. 41, no. 6, pp. 813–817, 1997. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- C. Zaleski, A. S. Bassett, K. Tam, A. L. Shugar, E. W. C. Chow, and E. McPherson, “The Co-occurrence of early onset Parkinson disease and 22q11.2 deletion syndrome,” American Journal of Medical Genetics, Part A, vol. 149, no. 3, pp. 525–528, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J. Booij, T. Van Amelsvoort, and E. Boot, “Co-occurrence of early-onset Parkinson disease and 22q11.2 deletion syndrome: potential role for dopamine transporter imaging,” American Journal of Medical Genetics A, vol. 152, no. 11, pp. 2937–2938, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- S. Stagi, E. Lapi, E. Gambineri et al., “Bone density and metabolism in subjects with microdeletion of chromosome 22q11 (del22q11),” European Journal of Endocrinology, vol. 163, no. 2, pp. 329–337, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- D. G. Changaris, L. C. Keil, and W. B. Severs, “Angiotensin II immunohistochemistry of the rat brain,” Neuroendocrinology, vol. 25, no. 5, pp. 257–274, 1978. View at Scopus
- D. P. Healy and M. P. Printz, “Distribution of immunoreactive angiotensin II, angiotensin I, angiotensinogen, and renin in the central nervous system of intact and nephrectomized rats,” Hypertension, vol. 6, supplement 2, pp. 130–136, 1984. View at Scopus
- D. Ganten, K. Hermann, and C. Bayer, “Angiotensin synthesis in the brain and increased turnover in hypertensive rats,” Science, vol. 221, no. 4613, pp. 869–871, 1983. View at Scopus
- V. J. Dzau, J. Ingelfinger, R. E. Pratt, and K. E. Ellison, “Identification of renin and angiotensinogen messenger RNA sequences in mouse and rat brains,” Hypertension, vol. 8, no. 6, pp. 544–548, 1986. View at Scopus
- G. S. Zubenko, L. Volicer, and L. K. Direnfeld, “Cerebrospinal fluid levels of angiotensin-converting enzyme in Alzheimer's disease, Parkinson's disease and progressive supranuclear palsy,” Brain Research, vol. 328, no. 2, pp. 215–221, 1985. View at Publisher · View at Google Scholar
- C. H. Konings, M. A. Kuiper, P. L. M. Bergmans, A. M. Grijpma, G. J. van Kamp, and C. E. Wolters, “Increased angiotensin-eonverting enzyme activity in cerebrospinal fluid of treated patients with Parkinson's disease,” Clinica Chimica Acta, vol. 231, no. 1, pp. 101–106, 1994. View at Publisher · View at Google Scholar · View at Scopus
- R. Kurosaki, Y. Muramatsu, H. Kato et al., “Effect of angiotensin-converting enzyme inhibitor perindopril on interneurons in MPTP-treated mice,” European Neuropsychopharmacology, vol. 15, no. 1, pp. 57–67, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- T. A. Jenkins, J. Y. F. Wong, D. W. Howells, F. A. O. Mendelsohn, and S. Y. Chai, “Effect of chronic angiotensin-converting enzyme inhibition on striatal dopamine content in the MPTP-treated mouse,” Journal of Neurochemistry, vol. 73, no. 1, pp. 214–219, 1999. View at Publisher · View at Google Scholar · View at Scopus
- K. A. Reardon, F. A. O. Mendelsohn, S. Y. Chai, and M. K. Horne, “The angiotensin converting enzyme (ACE) inhibitor, perindopril, modifies the clinical features of Parkinson's disease,” Australian and New Zealand Journal of Medicine, vol. 30, no. 1, pp. 48–53, 2000. View at Scopus
- J. J. Lin, K. C. Yueh, D. C. Chang, and S. Z. Lin, “Association between genetic polymorphism of angiotensin-converting enzyme gene and Parkinson's disease,” Journal of the Neurological Sciences, vol. 199, no. 1-2, pp. 25–29, 2002. View at Publisher · View at Google Scholar · View at Scopus
- J. J. Lin, K. C. Yueh, S. Z. Lin, H. J. Harn, and J. T. Liu, “Genetic polymorphism of the angiotensin converting enzyme and l-dopa-induced adverse effects in Parkinson's disease,” Journal of the Neurological Sciences, vol. 252, no. 2, pp. 130–134, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- G. Mellick, D. D. Buchanan, S. J. McCann et al., “The ACE deletion Polymorphism is not associated with Parkinson's disease,” European Neurology, vol. 41, no. 2, pp. 103–106, 1999. View at Publisher · View at Google Scholar · View at Scopus
- E. Pascale, C. Purcaro, E. Passarelli et al., “Genetic polymorphism of Angiotensin-Converting Enzyme is not associated with the development of Parkinson's disease and of l-dopa-induced adverse effects,” Journal of the Neurological Sciences, vol. 276, no. 1-2, pp. 18–21, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J. L. Pérez-Castrillón, I. Justo, A. Sanz, D. De Luis, and A. Dueñas, “Effect of angiotensin converting enzyme inhibitors on 1.25-(OH)2 D levels of hypertensive patients. Relationship with ACE polymorphisms,” Hormone and Metabolic Research, vol. 38, no. 12, pp. 812–816, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- W. Xiang, J. Kong, S. Chen et al., “Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems,” American Journal of Physiology, vol. 288, no. 1, pp. E125–E132, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- H. Hagiwara, H. Furuhashi, K. Nakaya, and Y. Nakamura, “Effects of vitamin D3 and related compounds on angiotensin converting enzyme activity of endothelial cells and on release of plasminogen activator from them,” Chemical and Pharmaceutical Bulletin, vol. 36, no. 12, pp. 4858–4864, 1988. View at Scopus
- J. R. Hascalovici, J. Vaya, S. Khatib et al., “Brain sterol dysregulation in sporadic AD and MCI: relationship to heme oxygenase-1,” Journal of Neurochemistry, vol. 110, no. 4, pp. 1241–1253, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- D. E. Barañano and S. H. Snyder, “Neural roles for heme oxygenase: contrasts to nitric oxide synthase,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 20, pp. 10996–11002, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- R. Castellani, M. A. Smith, P. L. Richey, and G. Perry, “Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease,” Brain Research, vol. 737, no. 1-2, pp. 195–200, 1996. View at Publisher · View at Google Scholar · View at Scopus
- I. Mateo, J. Infante, P. Sánchez-Juan et al., “Serum heme oxygenase-1 levels are increased in Parkinson's disease but not in Alzheimer's disease,” Acta Neurologica Scandinavica, vol. 121, no. 2, pp. 136–138, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- E. Oermann, H. J. Bidmon, O. W. Witte, and K. Zilles, “Effects of 1α,25 dihydroxyvitamin D3 on the expression of HO-1 and GFAP in glial cells of the photothrombotically lesioned cerebral cortex,” Journal of Chemical Neuroanatomy, vol. 28, no. 4, pp. 225–238, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J. Soós, J. I. Engelhardt, L. Siklós, L. Havas, and K. Majtényi, “The expression of PARP, NF-κB and parvalbumin is increased in Parkinson disease,” NeuroReport, vol. 15, no. 11, pp. 1715–1718, 2004. View at Publisher · View at Google Scholar · View at Scopus
- H. Wang, M. Shimoji, S. W. Yu, T. M. Dawson, and V. L. Dawson, “Apoptosis inducing factor and PARP-mediated injury in the MPTP mouse model of Parkinson's disease,” Annals of the New York Academy of Sciences, vol. 991, pp. 132–139, 2003. View at Scopus
- A. S. Mandir, S. Przedborski, V. Jackson-Lewis et al., “Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 10, pp. 5774–5779, 1999. View at Scopus
- A. Iwashita, K. Mihara, S. Yamazaki et al., “A new poly(ADP-ribose) polymerase inhibitor, FR261529 [2-(4-chlorophenyl)-5-quinoxalinecarboxamide], ameliorates methamphetamine-induced dopaminergic neurotoxicity in mice,” Journal of Pharmacology and Experimental Therapeutics, vol. 310, no. 3, pp. 1114–1124, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- H. Yokoyama, H. Kuroiwa, T. Tsukada, H. Uchida, H. Kato, and T. Araki, “Poly(ADP-ribose)polymerase inhibitor can attenuate the neuronal death after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice,” Journal of Neuroscience Research, vol. 88, no. 7, pp. 1522–1536, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J. Infante, P. Sánchez-Juan, I. Mateo et al., “Poly (ADP-ribose) polymerase-1 (PARP-1) genetic variants are protective against Parkinson's disease,” Journal of the Neurological Sciences, vol. 256, no. 1-2, pp. 68–70, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- M. Bhatia, J. B. Kirkland, and K. A. Mecking-Gill, “Modulation of poly(ADP-ribose) polymerase during neurophilic and monocytic differentiation of promyelocytic (NB4) and myelocytic (HL-60) leakaemia cells,” Biochemical Journal, vol. 308, pp. 131–137, 1995.
- J. G. Mabley, R. Wallace, P. Pacher, K. Murphy, and C. Szabó, “Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D,” International Journal of Molecular Medicine, vol. 19, no. 6, pp. 947–952, 2007. View at Scopus
- M. Shen and A. Yen, “Nicotinamide cooperates with retinoic acid and 1,25-dihydroxyvitamin D3 to regulate cell differentiation and cell cycle arrest of human myeloblastic leukemia cells,” Oncology, vol. 76, no. 2, pp. 91–100, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- M. Moore, A. Piazza, Y. Nolan, and M. A. Lynch, “Treatment with dexamethasone and vitamin D3 attenuates neuroinflammatory age-related changes in rat hippocampus,” Synapse, vol. 61, no. 10, pp. 851–861, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- A. K. McAllister, “Neurotrophins and neuronal differentiation in the central nervous system,” Cellular and Molecular Life Sciences, vol. 58, no. 8, pp. 1054–1060, 2001. View at Scopus
- T. Numakawa, T. Matsumoto, M. Numakawa, M. Richards, S. Yamawaki, and H. Kunugi, “Protection action of neurotrophic factors and estrogen against oxidative stress-mediated neurodegeneration,” Journal of Toxicology, vol. 2011, Article ID 405194, 12 pages, 2011. View at Publisher · View at Google Scholar · View at PubMed
- E. Garbayo, E. Ansorena, J. L. Lanciego, M. J. Blanco-Prieto, and M. S. Aymerich, “Long-term neuroprotection and neurorestoration by glial cell-derived neurotrophic factor microspheres for the treatment of Parkinson's disease,” Movement Disorders, vol. 26, no. 10, pp. 1943–1947, 2011. View at Publisher · View at Google Scholar · View at PubMed
- M. H. Voutilainen, S. Bäck, E. Pörsti et al., “Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's disease,” Journal of Neuroscience, vol. 29, no. 30, pp. 9651–9659, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- Z.-P. Sun, L. Gong, S.-H. Huang, Z. Geng, L. Cheng, and Z.-Y. Chen, “Intracellular trafficking and secretion of cerebral dopamine neurotrophic factor in neurosecretory cells,” Journal of Neurochemistry, vol. 117, no. 1, pp. 121–132, 2011. View at Publisher · View at Google Scholar · View at PubMed
- Q. Yan, M. J. Radeke, C. R. Matheson, J. Talvenheimo, A. A. Welcher, and S. C. Feinstein, “Immunocytochemical localization of TrkB in the central nervous system of the adult rat,” Journal of Comparative Neurology, vol. 378, no. 1, pp. 135–157, 1997. View at Publisher · View at Google Scholar · View at Scopus
- S. Marco, J. Saura, E. Prez-Navarro, M. J. Mart, E. Tolosa, and J. Alberch, “Regulation of c-Ret, GFRα1, and GFRα2 in the substantia nigra pars compacta in a rat model of Parkinson's disease,” Journal of Neurobiology, vol. 52, no. 4, pp. 343–351, 2002. View at Publisher · View at Google Scholar · View at PubMed
- M. Mogi, A. Togari, T. Kondo et al., “Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinson's disease,” Neuroscience Letters, vol. 270, no. 1, pp. 45–48, 1999. View at Publisher · View at Google Scholar · View at Scopus
- D. W. Howells, M. J. Porritt, J. Y. F. Wong et al., “Reduced BDNF mRNA expression in the Parkinson's disease substantia nigra,” Experimental Neurology, vol. 166, no. 1, pp. 127–135, 2000. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- P. Scalzo, A. Kümmer, T. L. Bretas, F. Cardoso, and A. L. Teixeira, “Serum levels of brain-derived neurotrophic factor correlate with motor impairment in Parkinson's disease,” Journal of Neurology, vol. 257, no. 4, pp. 540–545, 2010. View at Publisher · View at Google Scholar · View at PubMed
- J.-M. Choi, J.-H. Hong, M.-J. Chae et al., “Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease,” Neuroscience Letters, vol. 493, no. 3, pp. 97–101, 2011. View at Publisher · View at Google Scholar · View at PubMed
- L. Chen, Y. Wang, H. Xiao et al., “The 712A/G polymorphism of Brain-derived neurotrophic factor is associated with Parkinson's disease but not Major Depressive Disorder in a Chinese Han population,” Biochemical and Biophysical Research Communications, vol. 408, no. 2, pp. 318–321, 2011. View at Publisher · View at Google Scholar · View at PubMed
- P. Naveilhan, I. Neveu, C. Baudet et al., “1,25-dihydroxyvitamin D3 regulates the expression of the low-affinity neurotrophin receptor,” Molecular Brain Research, vol. 41, no. 1-2, pp. 259–268, 1996. View at Publisher · View at Google Scholar · View at Scopus
- B. Sanchez, E. Lopez-Martin, C. Segura, J. L. Labandeira-Garcia, and R. Perez-Fernandez, “1,25-Dihydroxyvitamin D3 increases striatal GDNF mRNA and protein expression in adult rats,” Molecular Brain Research, vol. 108, no. 1-2, pp. 143–146, 2002. View at Publisher · View at Google Scholar · View at Scopus
- P. Naveilhan, I. Neveu, D. Wion, and P. Brachet, “1,25-Dihydroxyvitamin D3, an inducer of glial cell line-derived neurotrophic factor,” NeuroReport, vol. 7, no. 13, pp. 2171–2175, 1996. View at Scopus
- F. Féron, T. H. J. Burne, J. Brown et al., “Developmental Vitamin D3 deficiency alters the adult rat brain,” Brain Research Bulletin, vol. 65, no. 2, pp. 141–148, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- M. P. Smith, A. Fletcher-Turner, D. M. Yurek, and W. A. Cass, “Calcitriol protection against dopamine loss induced by intracerebroventricular administration of 6-hydroxydopamine,” Neurochemical Research, vol. 31, no. 4, pp. 533–539, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- B. Sanchez, J. L. Relova, R. Gallego, I. Ben-Batalla, and R. Perez-Fernandez, “1,25-Dihydroxyvitamin D3 administration to 6-hydroxydopamine-lesioned rats increases glial cell line-derived neurotrophic factor and partially restores tyrosine hydroxylase expression in substantia nigra and striatum,” Journal of Neuroscience Research, vol. 87, no. 3, pp. 723–732, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- H. Ryu, J. Lee, K. Zaman et al., “Sp1 and Sp3 are oxidative stress-inducible, antideath transcription factors in cortical neurons,” Journal of Neuroscience, vol. 23, no. 9, pp. 3597–3606, 2003.
- J. Wang and M. J. Bannon, “Sp1 and Sp3 activate transcription of the human dopamine transporter gene,” Journal of Neurochemistry, vol. 93, no. 2, pp. 474–482, 2005. View at Publisher · View at Google Scholar · View at PubMed
- S. Yajima, S. H. Lee, T. Minowa, and M. M. Mouradian, “Sp family transcription factors regulate expression of rat D2 dopamine receptor gene,” DNA and Cell Biology, vol. 17, no. 5, pp. 471–479, 1998.
- D. P. Figlewicz, S. B. Evans, J. Murphy, M. Hoen, and D. G. Baskin, “Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat,” Brain Research, vol. 964, no. 1, pp. 107–115, 2003. View at Publisher · View at Google Scholar · View at Scopus
- M. Takahashi, T. Yamada, I. Tooyama et al., “Insulin receptor mRNA in the substantia nigra in Parkinson's disease,” Neuroscience Letters, vol. 204, no. 3, pp. 201–204, 1996. View at Publisher · View at Google Scholar · View at Scopus
- R. Sandyk, “The relationship between diabetes mellitus and Parkinson's disease,” International Journal of Neuroscience, vol. 69, no. 1–4, pp. 125–130, 1993. View at Scopus
- M. D'Amelio, P. Ragonese, G. Callari et al., “Diabetes preceding Parkinson's disease onset. A case-control study,” Parkinsonism and Related Disorders, vol. 15, no. 9, pp. 660–664, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- Q. Xu, Y. Park, X. Huang et al., “Diabetes and risk of Parkinson's disease,” Diabetes Care, vol. 34, no. 4, pp. 910–915, 2011. View at Publisher · View at Google Scholar · View at PubMed
- E. Schernhammer, J. Hansen, K. Rugbjerg, L. Wermuth, and B. Ritz, “Diabetes and the risk of developing Parkinson's disease in Denmark,” Diabetes Care, vol. 34, no. 5, pp. 1102–1108, 2011. View at Publisher · View at Google Scholar · View at PubMed
- K. M. Powers, T. Smith-Weller, G. M. Franklin, W. T. Longstreth, P. D. Swanson, and H. Checkoway, “Diabetes, smoking, and other medical conditions in relation to Parkinson's disease risk,” Parkinsonism and Related Disorders, vol. 12, no. 3, pp. 185–189, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- C. Becker, G. P. Brobert, S. Johansson, S. S. Jick, and C. R. Meier, “Diabetes in patients with idiopathic parkinson's disease,” Diabetes Care, vol. 31, no. 9, pp. 1808–1812, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- M. A. Fishel, G. S. Watson, T. J. Montine et al., “Hyperinsulinemia provokes synchronous increases in central inflammation and β-amyloid in normal adults,” Archives of Neurology, vol. 62, no. 10, pp. 1539–1544, 2005. View at Publisher · View at Google Scholar · View at Scopus
- J. K. Morris, H. Zhang, A. A. Gupte, G. L. Bomhoff, J. A. Stanford, and P. C. Geiger, “Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease,” Brain Research, vol. 1240, no. C, pp. 185–195, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- K. R. Wilhelm, K. Yanamandra, M. A. Gruden et al., “Immune reactivity towards insulin, its amyloid and protein S100B in blood sera of Parkinson's disease patients,” European Journal of Neurology, vol. 14, no. 3, pp. 327–334, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- M. H. Van Woert and P. S. Mueller, “Glucose, insulin, and free fatty acid metabolism in Parkinson's disease treated with levodopa,” Clinical Pharmacology and Therapeutics, vol. 12, no. 2, pp. 360–367, 1971. View at Scopus
- A. E. Boyd 3rd. A.E., H. E. Lebovitz, and J. M. Feldman, “Endocrine function and glucose metabolism in patients with Parkinson's disease and their alternation by L-Dopa,” Journal of Clinical Endocrinology and Metabolism, vol. 33, no. 5, pp. 829–837, 1971. View at Scopus
- E. Murzi, Q. Contreras, L. Teneud et al., “Diabetes decreases limbic extracellular dopamine in rats,” Neuroscience Letters, vol. 202, no. 3, pp. 141–144, 1996. View at Publisher · View at Google Scholar · View at Scopus
- H. Shimizu, Y. Shimomura, M. Takahashi, I. Kobayashi, and S. Kobayashi, “Dopamine receptor in the streptozotocin-induced diabetic rats,” Experimental and Clinical Endocrinology, vol. 95, no. 2, pp. 263–266, 1990. View at Scopus
- H. Kaur, K. C. Donaghue, A. K. Chan et al., “Vitamin D deficiency is associated with retinopathy in children and adolescents with type 1 diabetes,” Diabetes Care, vol. 34, no. 6, pp. 1400–1402, 2011. View at Publisher · View at Google Scholar · View at PubMed
- Y.-F. Yiu, Y.-H. Chan, K.-H. Yiu et al., “Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes,” Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 5, pp. E830–E835, 2011. View at Publisher · View at Google Scholar · View at PubMed
- J. Verhaeghe, A. M. H. Suiker, R. Van Bree et al., “Increased clearance of 1,25(OH)2D3 and tissue-specific responsiveness to 1,25(OH)2D3 in diabetic rats,” American Journal of Physiology, vol. 265, no. 2, pp. E215–E223, 1993. View at Scopus
- Y. Sato, M. Kikuyama, and K. Oizumi, “High prevalence of vitamin D deficiency and reduced bone mass in Parkinson's disease,” Neurology, vol. 49, no. 5, pp. 1273–1278, 1997. View at Scopus
- M. L. Evatt, M. R. DeLong, M. Kumari, P. Auinger, M. P. McDermott, and V. Tangpricha, “High prevalence of hypovitaminosis D status in patients with early Parkinson disease,” Archives of Neurology, vol. 68, no. 3, pp. 314–319, 2011. View at Publisher · View at Google Scholar · View at PubMed
- P. Knekt, A. Kilkkinen, H. Rissanen, J. Marniemi, K. Sääksjärvi, and M. Heliövaara, “Serum vitamin D and the risk of Parkinson disease,” Archives of Neurology, vol. 67, no. 7, pp. 808–811, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- K. T. Peeyush, B. Savitha, A. Sherin, T. R. Anju, P. Jes, and C. S. Paulose, “Cholinergic, dopaminergic and insulin receptors gene expression in the cerebellum of streptozotocin-induced diabetic rats: functional regulation with Vitamin D3 supplementation,” Pharmacology Biochemistry and Behavior, vol. 95, no. 2, pp. 216–222, 2010. View at Publisher · View at Google Scholar · View at PubMed
- X. Cui, M. Pelekanos, T. H. J. Burne, J. J. McGrath, and D. W. Eyles, “Maternal vitamin D deficiency alters the expression of genes involved in dopamine specification in the developing rat mesencephalon,” Neuroscience Letters, vol. 486, no. 3, pp. 220–223, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J. Y. Wang, J. N. Wu, T. L. Cherng et al., “Vitamin D3 attenuates 6-hydroxydopamine-induced neurotoxicity in rats,” Brain Research, vol. 904, no. 1, pp. 67–75, 2001. View at Publisher · View at Google Scholar · View at Scopus
- K. Shinpo, S. Kikuchi, H. Sasaki, F. Moriwaka, and K. Tashiro, “Effect of 1,25-dihydroxyvitamin D3 on cultured mesencephalic dopaminergic neurons to the combined toxicity caused by L-buthionine sulfoximine and 1-methyl-4-phenylpyridine,” Journal of Neuroscience Research, vol. 62, no. 3, pp. 374–382, 2000. View at Publisher · View at Google Scholar · View at Scopus
- L. Derex and P. Trouillas, “Reversible Parkinsonism, hypophosphoremia, and hypocalcemia under vitamin D therapy: case report,” Movement Disorders, vol. 12, no. 4, pp. 612–613, 1997. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- D. J. Surmeier, “Calcium, ageing, and neuronal vulnerability in Parkinson's disease,” Lancet Neurology, vol. 6, no. 10, pp. 933–938, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- G. Martella, G. Madeo, T. Schirinzi et al., “Altered profile and D2-dopamine receptor modulation of high voltage-activated calcium current in striatal medium spiny neurons from animal models of Parkinson's disease,” Neuroscience, vol. 177, pp. 240–251, 2011. View at Publisher · View at Google Scholar · View at PubMed
- C. R. Lee and J. M. Tepper, “A calcium-activated nonselective cation conductance underlies the plateau potential in rat substantia nigra GABAergic neurons,” Journal of Neuroscience, vol. 27, no. 24, pp. 6531–6541, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- C. S. Chan, T. S. Gertler, and D. J. Surmeier, “A molecular basis for the increased vulnerability of substantia nigra dopamine neurons in aging and Parkinson's disease,” Movement Disorders, vol. 25, no. 1, pp. S63–S70, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- C. S. Chan, T. S. Gertler, and D. J. Surmeier, “Calcium homeostasis, selective vulnerability and Parkinson's disease,” Trends in Neurosciences, vol. 32, no. 5, pp. 249–256, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- A. Kupsch, M. Gerlach, S. C. Pupeter et al., “Pretreatment with nimodipine prevents MPTP-induced neurotoxicity at the nigral, but not at the striatal level in mice,” NeuroReport, vol. 6, no. 4, pp. 621–625, 1995. View at Scopus
- A. Kupsch, J. Sautter, J. Schwarz, P. Riederer, M. Gerlach, and W. H. Oertel, “1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in non-human primates is antagonized by pretreatment with nimodipine at the nigral, but not at the striatal level,” Brain Research, vol. 741, no. 1-2, pp. 185–196, 1996. View at Publisher · View at Google Scholar · View at Scopus
- S. Schuster, E. Doudnikoff, D. Rylander et al., “Antagonizing L-type Ca2+ Channel Reduces Development of Abnormal Involuntary Movement in the Rat Model of L-3,4-Dihydroxyphenylalanine-Induced Dyskinesia,” Biological Psychiatry, vol. 65, no. 6, pp. 518–526, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- E. Dursun, D. Gezen-Ak, and S. Yilmazer, “A novel perspective for Alzheimer's disease: vitamin D receptor suppression by amyloid-β and preventing the amyloid-β induced alterations by vitamin D in cortical neurons,” Journal of Alzheimer's Disease, vol. 23, no. 2, pp. 207–219, 2011. View at Publisher · View at Google Scholar · View at PubMed
- L. D. Brewer, N. M. Porter, D. S. Kerr, P. W. Landfield, and O. Thibault, “Chronic 1α,25-(OH)2vitamin D3 treatment reduces Ca2+-mediated hippocampal biomarkers of aging,” Cell Calcium, vol. 40, no. 3, pp. 277–286, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- L. D. Brewer, V. Thibault, K. C. Chen, M. C. Langub, P. W. Landfield, and N. M. Porter, “Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons,” Journal of Neuroscience, vol. 21, no. 1, pp. 98–108, 2001. View at Scopus
- J. J. Shan, B. Li, N. Taniguchi, and P. K. T. Pang, “Inhibition of membrane L-type calcium channel activity and intracellular calcium concentration by 24R,25-dihydroxyvitamin D3 in vascular smooth muscle,” Steroids, vol. 61, no. 11, pp. 657–663, 1996. View at Publisher · View at Google Scholar · View at Scopus
- C. W. K. Wu and H. H. Yeh, “Nerve growth factor rapidly increases muscarinic tone in mouse medial septum/diagonal band of Broca,” Journal of Neuroscience, vol. 25, no. 17, pp. 4232–4242, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- B. Poucet and T. Herrmann, “Septum and medial frontal cortex contribution to spatial problem-solving,” Behavioural Brain Research, vol. 37, no. 3, pp. 269–280, 1990. View at Publisher · View at Google Scholar · View at Scopus
- D. S. Olton, J. A. Walker, and F. H. Gage, “Hippocampal connections and spatial discrimination,” Brain Research, vol. 139, no. 2, pp. 295–308, 1978. View at Publisher · View at Google Scholar · View at Scopus
- T. Nishio, S. Furukawa, I. Akiguchi, and N. Sunohara, “Medial nigral dopamine neurons have rich neurotrophin support in humans,” NeuroReport, vol. 9, no. 12, pp. 2847–2851, 1998. View at Scopus
- V. Silani, A. Pizzuti, A. Falini et al., “β-Nerve growth factor (β-NGF) mRNA expression in the Parkinsonian adrenal gland,” Experimental Neurology, vol. 113, no. 2, pp. 166–170, 1991. View at Publisher · View at Google Scholar
- L. Lorigados Pedre, N. Pavón Fuentes, L. Alvarez González et al., “Nerve growth factor levels in parkinson disease and experimental parkinsonian rats,” Brain Research, vol. 952, no. 1, pp. 122–127, 2002. View at Publisher · View at Google Scholar · View at Scopus
- K. Shimoke and H. Chiba, “Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease,” Journal of Neuroscience Research, vol. 63, no. 5, pp. 402–409, 2001. View at Publisher · View at Google Scholar · View at Scopus
- Y. Hirata, T. Meguro, and K. Kiuchi, “Differential effect of nerve growth factor on dopaminergic neurotoxin-induced apoptosis,” Journal of Neurochemistry, vol. 99, no. 2, pp. 416–425, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- M. Salinas, R. Diaz, N. G. Abraham, C. M. R. De Galarreta, and A. Cuadrado, “Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner,” Journal of Biological Chemistry, vol. 278, no. 16, pp. 13898–13904, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- P. Forander, S. Soderstrom, C. Humpel, and I. Strömberg, “Chronic infusion of nerve growth factor into rat striatum increases cholinergic markers and inhibits striatal neuronal discharge rate,” European Journal of Neuroscience, vol. 8, no. 9, pp. 1822–1832, 1996. View at Scopus
- R. K. Chaturvedi, S. Shukla, K. Seth, and A. K. Agrawal, “Nerve growth factor increases survival of dopaminergic graft, rescue nigral dopaminergic neurons and restores functional deficits in rat model of Parkinson's disease,” Neuroscience Letters, vol. 398, no. 1-2, pp. 44–49, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- M. Li, S. Z. Zhang, Y. W. Guo et al., “Human umbilical vein-derived dopaminergic-like cell transplantation with nerve growth factor ameliorates motor dysfunction in a rat model of parkinson's disease,” Neurochemical Research, vol. 35, no. 10, pp. 1522–1529, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- A. Cornet, C. Baudet, I. Neveu, A. Baron-Van Evercooren, P. Brachet, and P. Naveilhan, “1,25-Dihydroxyvitamin D3 regulates the expression of VDR and NGF gene in Schwann cells in vitro,” Journal of Neuroscience Research, vol. 53, no. 6, pp. 742–746, 1998. View at Publisher · View at Google Scholar · View at Scopus
- I. M. Musiol and D. Feldman, “1,25-dihydroxyvitamin D3 induction of nerve growth factor in L929 mouse fibroblasts: effect of vitamin D receptor regulation and potency of vitamin D3 analogs,” Endocrinology, vol. 138, no. 1, pp. 12–18, 1997. View at Publisher · View at Google Scholar · View at Scopus
- T. D. Veenstra, M. Fahnestock, and R. Kumar, “An AP-1 site in the nerve growth factor promoter is essential for 1,25-dihydroxyvitamin D3-mediated nerve growth factor expression in osteoblasts,” Biochemistry, vol. 37, no. 17, pp. 5988–5994, 1998. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J. A. McClain, L. L. Phillips, and H. L. Fillmore, “Increased MMP-3 and CTGF expression during lipopolysaccharide-induced dopaminergic neurodegeneration,” Neuroscience Letters, vol. 460, no. 1, pp. 27–31, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- S. Lorenzl, N. Calingasan, L. Yang et al., “Matrix metalloproteinase-9 is elevated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice,” NeuroMolecular Medicine, vol. 5, no. 2, pp. 119–131, 2004. View at Publisher · View at Google Scholar · View at PubMed
- S. Y. Kim, M. S. Woo, J. S. Park, J. W. Hyun, Y. S. Kim, and H. S. Kim, “The neuroprotective role of tissue inhibitor of metalloproteinase-2 in MPP+- or 6-OHDA-treated SK-N-BE(2)C and SH-SY5Y human neuroblastoma cells,” Neuroscience Letters, vol. 468, no. 2, pp. 136–140, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- S. Kim, M. Moon, and S. Park, “Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease,” Journal of Endocrinology, vol. 202, no. 3, pp. 431–439, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- P. M. Timms, N. Mannan, G. A. Hitman et al., “Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders?” Monthly Journal of the Association of Physicians, vol. 95, no. 12, pp. 787–796, 2002. View at Publisher · View at Google Scholar · View at Scopus
- D. D. Dean, Z. Schwartz, J. Schmitz et al., “Vitamin D regulation of metalloproteinase activity in matrix vesicles,” Connective Tissue Research, vol. 35, no. 1–4, pp. 331–336, 1996. View at Scopus
- K. Bahar-Shany, A. Ravid, and R. Koren, “Upregulation of MMP-9 production by TNFα in keratinocytes and its attenuation by vitamin D,” Journal of Cellular Physiology, vol. 222, no. 3, pp. 729–737, 2010. View at Publisher · View at Google Scholar · View at PubMed
- K. Nakagawa, Y. Sasaki, S. Kato, N. Kubodera, and T. Okano, “22-Oxa-1α,25-dihydroxyvitamin D3 inhibits metastasis and angiogenesis in lung cancer,” Carcinogenesis, vol. 26, no. 6, pp. 1044–1054, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- E. Ricciotti and G. A. Fitzgerald, “Prostaglandins and inflammation,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 31, no. 5, pp. 986–1000, 2011. View at Publisher · View at Google Scholar · View at PubMed
- M. B. Mattammal, R. Strong, V. M. Lakshmi, H. D. Chung, and A. H. Stephenson, “Prostaglandin H synthetase-mediated metabolism of dopamine: implication for Parkinson's disease,” Journal of Neurochemistry, vol. 64, no. 4, pp. 1645–1654, 1995. View at Scopus
- T. Wang, Z. Pei, W. Zhang et al., “MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration,” FASEB Journal, vol. 19, no. 9, pp. 1134–1136, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- E. Carrasco, D. Casper, and P. Werner, “PGE2 receptor EP1 renders dopaminergic neurons selectively vulnerable to low-level oxidative stress and direct PGE2 neurotoxicity,” Journal of Neuroscience Research, vol. 85, no. 14, pp. 3109–3117, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- C. Knott, G. Stern, and G. P. Wilkin, “Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2,” Molecular and Cellular Neuroscience, vol. 16, no. 6, pp. 724–739, 2000. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- P. Teismann, K. Tieu, D. K. Choi et al., “Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 9, pp. 5473–5478, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- P. Teismann and B. Ferger, “Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease,” Synapse, vol. 39, no. 2, pp. 167–174, 2001. View at Publisher · View at Google Scholar
- H. Chen, S. M. Zhang, M. A. Hernán et al., “Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease,” Archives of Neurology, vol. 60, no. 8, pp. 1059–1064, 2003. View at Publisher · View at Google Scholar · View at PubMed
- J. Moreno, A. V. Krishnan, S. Swami, L. Nonn, D. M. Peehl, and D. Feldman, “Regulation of prostaglandin metabolism by calcitriol attenuates growth stimulation in prostate cancer cells,” Cancer Research, vol. 65, no. 17, pp. 7917–7925, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- R. Aparna, J. Subhashini, K. R. Roy et al., “Selective inhibition of cyclooxygenase-2 (COX-2) by 1 α,25-dihydroxy- 16-ene-23-yne-vitamin D3, a less calcemic vitamin D analog,” Journal of Cellular Biochemistry, vol. 104, no. 5, pp. 1832–1842, 2008. View at Publisher · View at Google Scholar · View at PubMed
- A. Prigione, I. U. Isaias, A. Galbussera et al., “Increased oxidative stress in lymphocytes from untreated Parkinson's disease patients,” Parkinsonism and Related Disorders, vol. 15, no. 4, pp. 327–328, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- D. T. Dexter, C. J. Carter, F. R. Wells et al., “Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease,” Journal of Neurochemistry, vol. 52, no. 2, pp. 381–389, 1989. View at Scopus
- D. T. Dexter, A. E. Holley, W. D. Flitter et al., “Increased levels of lipid hydroperoxides in the Parkinsonian Substantia nigra: an HPLC and ESR study,” Movement Disorders, vol. 9, no. 1, pp. 92–97, 1994. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- H. Saggu, J. Cooksey, D. Dexter et al., “A selective increase in particulate superoxide dismutase activity in parkinsonian substantia nigra,” Journal of Neurochemistry, vol. 53, no. 3, pp. 692–697, 1989. View at Scopus
- G. Tesco, S. Latorraca, P. Piersanti, S. Sorbi, S. Piacentini, and L. Amaducci, “Free radical injury in skin cultured fibroblasts from Alzheimer's disease patients,” Annals of the New York Academy of Sciences, vol. 673, pp. 149–153, 1992. View at Publisher · View at Google Scholar · View at Scopus
- M. S. Cohen, D. E. Mesler, R. G. Snipes, and T. K. Gray, “1,25-Dihydroxyvitamin D3 activates secretion of hydrogen peroxide by human monocytes,” Journal of Immunology, vol. 136, no. 3, pp. 1049–1053, 1986. View at Scopus
- R. Levy and H. L. Malech, “Effect of 1,25-dihydroxyvitamin D3, lipopolysaccharide, or lipoteichoic acid on the expression of NADPH oxidase components in cultured human monocytes,” Journal of Immunology, vol. 147, no. 9, pp. 3066–3071, 1991. View at Scopus
- B. Y. Bao, H. J. Ting, J. W. Hsu, and Y. F. Lee, “Protective role of 1α, 25-dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells,” International Journal of Cancer, vol. 122, no. 12, pp. 2699–2706, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- D. Somjen, S. Katzburg, M. Grafi-Cohen, E. Knoll, O. Sharon, and G. H. Posner, “Vitamin D metabolites and analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cell line,” Journal of Steroid Biochemistry and Molecular Biology, vol. 123, no. 1-2, pp. 85–89, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- S. Hunot, F. Boissière, B. Faucheux et al., “Nitric oxide synthase and neuronal vulnerability in Parkinson's disease,” Neuroscience, vol. 72, no. 2, pp. 355–363, 1996. View at Publisher · View at Google Scholar · View at Scopus
- M. K. Barthwal, N. Srivastava, R. Shukla et al., “Polymorphonuclear leukocyte nitrite content and antioxidant enzymes in Parkinson's disease patients,” Acta Neurologica Scandinavica, vol. 100, no. 5, pp. 300–304, 1999.
- S. Singh, T. Das, A. Ravindran et al., “Involvement of nitric oxide in neurodegeneration: a study on the experimental models of Parkinson's disease,” Redox Report, vol. 10, no. 2, pp. 103–109, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- Y. Muramatsu, R. Kurosaki, H. Watanabe et al., “Cerebral alterations in a MPTP-mouse model of Parkinson's disease—an immunocytochemical study,” Journal of Neural Transmission, vol. 110, no. 10, pp. 1129–1144, 2003. View at Publisher · View at Google Scholar · View at PubMed
- J. B. Schulz, R. T. Matthews, M. M.K. Muqit, S. E. Browne, and M. F. Beal, “Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice,” Journal of Neurochemistry, vol. 64, no. 2, pp. 936–939, 1995.
- T. Dehmer, J. Lindenau, S. Haid, J. Dichgans, and J. B. Schulz, “Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo,” Journal of Neurochemistry, vol. 74, no. 5, pp. 2213–2216, 2000. View at Scopus
- D. Kaur, D. Lee, S. Ragapolan, and J. K. Andersen, “Glutathione depletion in immortalized midbrain-derived dopaminergic neurons results in increases in the labile iron pool: implications for Parkinson's disease,” Free Radical Biology and Medicine, vol. 46, no. 5, pp. 593–598, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J. M. Chang, M. C. Kuo, H. T. Kuo et al., “1-α,25-Dihydroxyvitamin D3 regulates inducible nitric oxide synthase messenger RNA expression and nitric oxide release in macrophage-like RAW 264.7 cells,” Journal of Laboratory and Clinical Medicine, vol. 143, no. 1, pp. 14–22, 2004. View at Publisher · View at Google Scholar · View at Scopus
- E. Garcion, S. Nataf, A. Berod, F. Darcy, and P. Brachet, “1,25-Dihydroxyvitamin D3 inhibits the expression of inducible nitric oxide synthase in rat central nervous system during experimental allergic encephalomyelitis,” Molecular Brain Research, vol. 45, no. 2, pp. 255–267, 1997. View at Publisher · View at Google Scholar · View at Scopus
- O. Equils, Y. Naiki, A. M. Shapiro et al., “1,25-Dihydroxyvitamin D3 inhibits lipopolysaccharide-induced immune activation in human endothelial cells,” Clinical and Experimental Immunology, vol. 143, no. 1, pp. 58–64, 2006. View at Publisher · View at Google Scholar · View at PubMed
- E. Garcion, L. Sindji, G. Leblondel, P. Brachet, and F. Darcy, “1,25-dihydroxyvitamin D3 regulates the synthesis of γ-glutamyl transpeptidase and glutathione levels in rat primary astrocytes,” Journal of Neurochemistry, vol. 73, no. 2, pp. 859–866, 1999. View at Publisher · View at Google Scholar · View at Scopus