Volume 2013 (2013), Article ID 176027, 26 pages
Memory and Self–Neuroscientific Landscapes
1Physiological Psychology, University of Bielefeld, Universitaetsstraße 25, 33615 Bielefeld, Germany
2Center of Excellence “Cognitive Interaction Technology” (CITEC), University of Bielefeld, 33615 Bielefeld, Germany
3Hanse Institute of Advanced Science, P. O. Box 1344, 27733 Delmenhorst, Germany
Received 13 March 2013; Accepted 22 April 2013
Academic Editors: C. Bishop and Y. Bozzi
Copyright © 2013 Hans J. Markowitsch. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Relations between memory and the self are framed from a number of perspectives—developmental aspects, forms of memory, interrelations between memory and the brain, and interactions between the environment and memory. The self is seen as dividable into more rudimentary and more advanced aspects. Special emphasis is laid on memory systems and within them on episodic autobiographical memory which is seen as a pure human form of memory that is dependent on a proper ontogenetic development and shaped by the social environment, including culture. Self and episodic autobiographical memory are seen as interlocked in their development and later manifestation. Aside from content-based aspects of memory, time-based aspects are seen along two lines—the division between short-term and long-term memory and anterograde—future-oriented—and retrograde—past-oriented memory. The state dependency of episodic autobiographical is stressed and implications of it—for example, with respect to the occurrence of false memories and forensic aspects—are outlined. For the brain level, structural networks for encoding, consolidation, storage, and retrieval are discussed both by referring to patient data and to data obtained in normal participants with functional brain imaging methods. It is elaborated why descriptions from patients with functional or dissociative amnesia are particularly apt to demonstrate the facets in which memory, self, and personal temporality are interwoven.
In this review I will stress the importance of memory for a healthy self and will point to constituents that are necessary to develop and maintain an integrated interplay between information processing and self-development. Data from neurological and psychiatric patients will be used to demonstrate the challenges this interplay undergoes when somatic and psychic prerequisites are impaired or altered. Furthermore, a modern view on memory systems and processes is provided. From this data it will be concluded that there is an intimate relation between autobiographical memory and the self . The data will also reveal that the self is constituted of a number of features and therefore goes beyond memory as such [2–7].
2. Memory Is of Survival Value and Constitutes the Essence of a Personality
Memory constitutes an essential feature of our personality. This was already stated in 1870 in a booklet by Hering  (which in 1895 was translated into English ). He wrote on page 12 (my translation):
Memory connects innumerable single phenomena into a whole, and just as the body would be scattered like dust in countless atoms if the attraction of matter did not hold it together so consciousness—without the connecting power of memory—would fall apart in as many fragments as it contains moments.
Hering therefore stated that human memory is necessary in our present to recruit ideas and facts from the past in order to manage our future . Furthermore, memory is the glue which makes us a unique personality. However, not only we as human beings possess the ability to store information perceived in the environment. Every animal learns about its social and biological environment. Long-term storage of information has most likely a survival value: For an animal it is helpful to maintain information on good and bad food, as healthy and tasting food prolongs life and is emotionally satisfying. On the other hand, the avoidance of poisonous food helps to maintain a healthy body and to avoid being intoxicated. In this way, memory has survival value for an individual. Similarly, it can be proposed that memorizing odors of members of the own and of other species allows to infer whether another individual is ready for mating or may be aggressive. We all know that not only dogs communicate to a considerable extent via sniffing, but that also many rodents, carnivores, and ungulates mark their territory so that another male is likely to avoid their territory and thereby avoids serious injuries from being attacked by a stronger individual. In this way survival of the species is prolonged via memory.
These examples also point to brain regions which early in phylogeny were mainly engaged in odor  but later on in phylogeny were necessary for processing emotions and memory. Even in human beings it has been found that our first memories are strongly odor related: Willander and Larsson  presented odor, word, and picture cues to elicit past memories from adults and found that the odor cues elicited mainly memories from the first decade of life, while the word and picture elicited mainly past events from the second decade of life. The brain regions, initially (in phylogeny) relevant for odor processing, are subsumed under the heading “limbic system”  and are discussed as mediating between the phylogenetically old structures of the brain stem and the advanced structures of the neocortex [14–16]. Among them, the amygdala is necessary for a proper interpretation of the social and biological environment [17–22] and the hippocampal formation for the transfer of memory from short-term to long-term storage and possibly also for retrieval . Other limbic and paralimbic [24, 25] structures such as the septal nuclei , medial and anterior thalamic nuclei  support the emotional colorization of memories and are nowadays seen as overlapping with the so-called default mode network [28, 29], a system of structures active when the brain is at wakeful rest and not focused towards stimuli in the outer world. Recent data indicate that this system provides the neurophysiological basis for self-processing operations such as first-person perspective taking and an experience of agency [30, 31].
3. The Development of Memory and the Self
It is obvious that human babies have at best tiny spoors of memory from their prenatal life. They first start by exploring the environment with their senses—from odor to the haptic sense. By doing so they learn to associate environmental objects with specific feelings—that the wooden frame of the bed may be resistant and harmful when touched too vehement, or that the breasts of the mother smell and taste well. Thereafter they continue by associating objects with heard expressions and gradually acquire language. And even later they start to understand the meaning of time [32, 33]. Theory of mind functions follow both with respect to cognitive and affective situations (becoming able to make inferences on another person’s intentions and becoming able to make inferences on how he or she might feel) [34–36]. Only when having reached this state of mind, a self becomes established and autobiographical memories are possible [37–40]. However, even then there are of course concepts of the self that are only established later during adolescence [41–45].
The three main constituents for the development of autobiographical memory and the self are the development of language and the maturation of the brain [46, 47]. Of course, this process is culture shaped as well [48, 49] and continues into later childhood [50, 51]. Interestingly, adults are not aware of their first years of life; we speak of infantile amnesia. Memories of about the first three years of life are not consciously remembered at adulthood [52–55]. As Harpaz-Rotem and Hirst  showed, the birth order has an effect: first-born children or single children develop autobiographic memory and a self earlier than children appearing later in birth order (i.e., later-born children have their first memories stemming from a later age as adults). This is most likely due to the fact that the first-born child is addressed individually by parents and peer group, while later born children are addressed as a group. This hypothesis is confirmed by the fact that in societies where children are treated less individually as in a kibbutz  or in East Asia [54–56], they also develop autobiographical memories and a self later in time. For a more detailed discussion of this topic see the review of Markowitsch and Staniloiu .
Also the brain representation of the self may differ between Westerners and East Asians. Zhu et al.  found with functional brain imaging that Westerners used the medial prefrontal cortex exclusively for representation of the self, while Chinese people used it for representation of the self and of their mother. (It should, however, be mentioned that these data hold for individuals with normal brains. As Philippi et al.  stressed, the situation in patients with damage to the medial prefrontal cortex speaks for functional reorganization and for the use of more distributed neural networks for representing the self.)
4. What Constitutes the Self?
Everyone has an implicit idea on what the self is. That we are ourselves is evident if we are adult, healthy individuals. The situation becomes different when we ask whether a human baby has a self, a patient with severe Alzheimer’s disease has a self, or a water snail has a self. Apparently “selves” are unequal. Simple animal species have in common with human beings that they possess a body (“embodiment”—subjective experience of a body [60, 61]), they have a metabolism and a nervous system. Most species can avoid too much light or heat or coldness; also human babies try to avoid pain and to get food. Other species are not only aware of the fact that they want to live in a kind of homoeostasis, but they are able to cheat and to communicate. And still others may be able to recognize themselves in the mirror, including apes, whales, elephants, and human children of about 18 months of age [62–64]. Butler and coworkers  recently raised the question whether there are differences in recognizing oneself in mirrors, or on photographs, or in TV, and so forth. Other scientists alerted to the fact that there might be a difference between self-recognition ability in species living in groups or hordes (e.g., gorillas) and living isolated as individuals (e.g., orangutans). Self-recognition is nevertheless recognized as a distinct feature of self-awareness or self-consciousness. However, everyone knows that self-awareness does not make apes equal to human beings—apes do not build skyscrapers and do not know that they will die. Several researchers—such as Damasio —argue that there are hierarchies of consciousness. For Damasio there is the very simple “protoself” (important for homoeostasis), thereafter comes the “core self”, and then the “extended self”. The core self resembles core consciousness that allows animals to be aware and to react to their environment. The “extended self” requires a “personhood”, a self-identity, and consequently autobiographical memory. Though Damasio argued in part differently by attributing an extended self also to some animals, Tulving  proposes that only human beings should possess this, as only human beings “possess “autonoetic” episodic memory and the ability to mentally travel into the past and into the future, and that in that sense they are unique” (page 4). One might add that even not all human beings possess this feature—small children, severely brain-damaged, or mentally retarded patients are not able to mentally travel into past and future (see  for a more detailed discussion of this topic).
The self, as it is used in this paper, is seen as based on autobiographical memory and on “autonoetic consciousness” or “autonoesis” in the sense of Tulving —being aware of one’s being in time, both respect to one’s past and one’s “proscopic chronesthesia” (looking into the future, imaging the future). (In 2002 Tulving  described “autonoetic” as the “special kind of consciousness that allows us to be aware of subjective time in which events happened”; page 2.) Tulving  used the example of an Estonian children story to introduce the “spoon test”: A child of probably more than four years of age “dreams about going to a friend’s birthday party where the guests are served delicious chocolate pudding, her favorite. Alas, all she can do is to watch other children eat it, because everybody has to have her own spoon, and she did not bring one. So the next evening, determined not to have the same disappointing experience again, she goes to bed clutching a spoon in her hand.” (page 44). This test requires looking back into the past and looking forward into the future, without being triggered by an actual environmental event [69–71]. Having described the spoon test, this leads to the question of what constitutes (a) memory.
5. What Is Memory?
Similarly as with the term self that of memory is universally understood, but nevertheless not easy to define. Already some decades ago Sinz  on page 19 of his booklet gave the definition in which he wrote (my translation):
With memory we mean the learning-dependent storage of ontogenetically acquired information which is incorporated into neuronal structures in a selective, species-dependent way, and which can be recalled at arbitrary time points, that is, which can be made available for a situation-dependent behavior.
This definition emphasizes that the information is not genetically available but acquired postnatally via learning, and that different species may have different neural structures for incorporating and storing information. All this is of importance as it is known for instance that species have a genetically programmed repertoire of behaviors which is not learned (for instance, nest building in birds or the sucking, grasping, and swimming reflexes in human babies). Furthermore, species with a short life time naturally must have shorter consolidation periods for newly learned information than species with a long life time.
Recently, we have, however, accumulating evidence for major interplays between genetics and learning: the new field of “epigenetics” [73–78] refers to heritable changes in gene expression which do not change the DNA sequence, but still may be transmittable transgenerationally [79, 80]. Epigenetics describes mechanisms by which experiences (environmental stimulation) can modify gene function and gene expression . With respect to learning and memory, epigenetic modifications become of major importance [82–88]. Such results have broadened the definition of memory. Rensing et al.  proposed that the term “memory” might be used for plants and viruses as well and should include the following features:(i) selection (and/or modification) of preexisting information,(ii) activation of specific (selected) networks by information to be memorized,(iii) consolidation of the memory networks in a latent state (standby mode),(iv) retrieval of memory networks.
“Selection”, “activation”, “consolidation”, “stand by,” and “retrieval” (or “reactivation”) are the important terms in this model, which, however, characterize more traditional ways of memory processing as well, namely, “encoding” of information, “consolidating” it, “storing” it, and “retrieving” it. It should be emphasized here that retrieval of information leads to reconsolidation in the present state of circumstances, it in the present internal state of the individual (mood), and in the state of the presently acting environmental stimulation. Because of this, memories can act altered with repeated reactivation which may lead to the so-called false memory syndrome [90–93]. Tulving [67, 68] and, before him, Semon  have emphasized the state dependency of memory, implying that encoding and retrieval of information are modulated by the respective states of individual and environment. This means that if a person is in a depressive state, he or she will more likely encode the new information in a negative manner or will recall old information by emphasizing its negative aspects. State dependency also implies that it is ideal for retrieval, if the retrieval mode (condition) equals the encoding mode (condition) [95, 96].
5.1. False Memory Syndrome
The observation that information may be retrieved differently from how it was encoded has to be traced back to the process of perception. We know from numerous perceptual illusions (Figure 1) that our sensory systems interpret information subjectively and not physically correct. This implies that portions of the perceived information are inadequately encoded and stored and will consequently also be inadequately retrieved. Furthermore, the encoding specificity principle  which implies that memory is best when the same information present at encoding is also present at retrieval may lead to various forms of memory distortions if violated. Vice versa, Weingartner et al.  long ago have verified what had been known anecdotally before, namely, that encoding under alcohol intoxication should be followed by retrieval under alcohol intoxication. If individuals are sober at retrieval while they had learned the words while intoxicated, they performed poorer than in the matched condition.
We have investigated the phenomenon of false memories (which had been a major topic of Freud [99–101]) with functional brain imaging . University students viewed two short movies (less than 8 minutes altogether) and thereafter were positioned in a magnetic resonance imaging scanner where they saw single shots from the movies, related pictures which, however, had not been seen in the movies, and unrelated pictures. Their task was to decide whether they had seen the pictures or not. Surprisingly, they gave nearly 45% wrong answers by stating that they saw a picture that had not been part of the movie or that they did not see a picture which in fact had been part of the movie. Even more astonishingly was that the brain activations towards false versus correct responses revealed a distinct pattern with true responses showing medial prefrontal and false responses posterior activations in the visual association cortex and the precuneus, all bilaterally (Figure 2). While this might be interpreted as showing that the “brain’s responses” were more distinct and predictable than the behavioral responses, some caution is advisable. Subjects probably would have liked to respond more frequently with “I do not know” or “I’m not sure”; however, they were forced to press a “yes” or a “no” button. Consequently, the activations may reflect a somewhat artificial clarity or distinctiveness.
5.2. Possible Implications for Jurisdiction
Nevertheless, these results—together with related ones [103–109]—indicate that it is in principle possible to obtain neural correlates for false responses. It also might be possible in the foreseeable future to detect with functional brain imaging whether a patient is simulating pain or feels it indeed . Such findings may have similar implications for court decisions as those on lie detection [111–114].
After questionable results with measures of the galvanic skin response [115, 116] or with thermal imaging (flushing) , researchers more recently have started to use functional brain imaging in order to differentiate lie from truth. This research probably started with a functional positron emission tomographic study  which was based on two similar ones where the neural correlates of true autobiographic retrieval were investigated [119, 120]. We found that true memories led to activations in the right amygdala and right temporofrontal region, while lies resulted in—somewhat similar to the results of our false memory study —activations in a region around the precuneus. Later studies, performed with functional magnetic resonance imaging, provided partly inconsistent results [121–140], though, as Spence  stated, some consistencies. Among them were longer response times during lying compared to telling the truth, greater ventrolateral and anterior cingulate activity during lying, and no brain regions where truth elicited greater activity than lies. Of course, this kind of research, which already led to practical applications in the court, has been criticized as being unethical .
Numerous other techniques, based, for example, on electrophysiological recordings  or smart questioning , have been proposed and there is a wide variety of so-called symptom validity tests available which also have been named lie detection tests. Most of these test memory in a way that patients assume it is a difficult test, while in fact it is rather simple. Some are based on probability estimates. Examples are the test of memory malingering (TOMM) [144–146], the word memory test [146–148], and the Amsterdam short term memory test [149, 150]. M. Martins and I. P. Martins  evaluated malingering criteria of the word memory test and Bolan et al. recently compared advantages and disadvantages of these three tests . A problem of these tests lies in the fact that if patients show a lack of effort, they perform as poorly as if they would consciously lie [153, 154]. Nevertheless, in clinical assessments, especially when patients demand compensation, these tests are used regularly. Interestingly, Sip et al.  recently found with functional brain imaging increased activity in the left temporal pole and the right hippocampal and parahippocampal regions when participants believed their false claims could be detected, but not when they thought the lie detector was switched off.
5.3. Memory and Time
As mentioned above, recalling mnestic information requires that it has been stored successfully before and therefore also successfully encoded and consolidated. Memory is therefore embedded in time. This is above all reflected in the usual distinction between short-term and long-term memory with short-term memory lasting seconds to a few minutes and long-term lasting for longer time periods, for some information lifelong . Figure 3 depicts this time-based processing of information and Table 1 provides definition for terms which are relevant to psychological memory processes.
Alternatives to the short-term long-term memory dichotomy such as a third, intermediate memory system  or the depth of encoding idea of continuous memory processing  did not withstand times and counterevidence. However, there is another time-based distinction which is of major importance, namely, that between anterograde and retrograde amnesia (Figure 4). After a brain infarct or after traumatic brain injury, or after a major psychotraumatic or stressful event, memory can be disturbed in two ways or in mainly one of two ways: The ability to store new information in long-term may be impaired, or the ability to retrieve old information which already had been stored in the brain. Retrograde amnesia frequently follows a time gradient so that very old information is largely preserved, while information from the time close to the injury or the stressful event may be blocked or unavailable for conscious retrieval. The preservation of old information is explainable by the facts that it came into a fresh, “empty” brain, that it probably was the first of its kind (i.e., it had the character of uniqueness), and that it was probably retrieved numerous times since its initial storage and therefore also reencoded and reconsolidated repeatedly. This relationship was already known to the French medical doctor Ribot  and is depicted in Figure 5. This figure stems from testing the retrograde memory of a retired psychology professor who had developed Korsakoff’s syndrome , a disease leading to degeneration of the medial thalamus and the mammillary bodies and to massive anterograde and variably intense retrograde amnesia.
5.4. Memory and Contents
The memory impairment in most patients with brain disease or a psychic blockade of memory retrieval (named “mnestic block syndrome” [164–169]) largely is confined to one system that we name the episodic autobiographical memory system [23, 57]. From the fact that this memory system is particularly vulnerable to adverse environmental or brain conditions it follows that there are other memory system. Aside from short-term memory which implies the online holding of limited bits of information for a very limited time (cf. Figure 2)—and which was extended by Baddeley [170–172] to “working memory” to reflect the fact that we also during retrieval partition information in manageable bits—we distinguish five long-term memory systems as depicted in Figure 6. These systems originate from a more limited number, namely, into two basic ones, one for largely automatically motor routines or procedures or habit, and another one for consciously processed facts and events. These memory systems are considered to evolve phylo- and ontogenetically in the same sequence starting with two principally subconsciously acting ones, “procedural memory” and the “priming system,” and continuing with “perceptual memory,” “semantic memory,” and the “episodic autobiographical memory” system, all of which are principally processed in a conscious, reflected manner (cf. Figure 6).
“Procedural memory” is used when handling a bike, driving a car, playing piano or chess, and so forth. We are not aware of the individual motor acts during performance—they are routine. For instance, when asking someone “what do you have to do first, when you want to change from the second into the third gear?”, one frequently obtains the answer “to press the clutch.” While in fact one first has to release the right foot from the gas pedal. On the same level as “procedural memory” “priming” acts. “Priming” refers to unconsciously perceived stimuli which nevertheless are incorporated in our nervous system and may, if later perceived again in the same (“perceptual priming”) or in a similar way (“conceptual priming”), lead to an easier or more frequent orientation to them, or to easier retrieval. In fact, psychologists have found that utmost of what we perceive we process unconsciously. With “perceptual memory” we reach the level of conscious information processing. “Perceptual memory” stands for familiarity processing, knowing what an item or object is, even at a presemantic (or nonsemantic) memory level; for example, to identify an apple independently of whether it is red or green, intact or half-eaten and also to be able to distinguish it from a peach or pear. “Semantic memory” deals with context-free facts, our school, and world knowledge. Finally then we speak of “episodic autobiographical memory” when personal events or episodes are meant. These refer to the conjunction of autonoetic consciousness (so the ability to reflect about oneself), subjective time perception, and the experiencing self. That is, we combine our ability to subjectively travel in time back and forth with the consciousness of our internal and external states of being. Tulving introduced his SPI model (SPI = serial, parallel, and independent) in 1995 , for which he stated that information is encoded into systems serially, stored in different systems in parallel, and can be retrieved independently. Hodges  and others proposed that processing of individual-centered episodes or events which are traceable with respect to time and place will, when repeated, finally lead to generalizations which are known as semantic or procedural memories. The so-called process of semantization [cf. Figure 2 in ; ] is in opposition to the fact that ontogenetic learning starts in childhood with semantic facts and only later includes personal events [37, 38].
Another classification of memory system divides between “declarative” and “nondeclarative” memories [176, 177]. Declarative memories are in Squire’s  definition both semantic facts and episodic (autobiographical) events. This combination is, however, less fruitful for science and for the distinction of impaired and preserved functions in brain-damaged individuals, as usually semantic facts processing is largely preserved after brain damage, while that of episodic autobiographical events is largely impaired.
6. Memory and the Brain
From ancient time onwards there were diverse ideas that intellectual functions have a representation in the brain [177, 178]. Especially the ideas of phrenology became quickly popular all over the world in the 19th century . Later on there was a debate about localization or antilocalization in the brain  which continues until today . Indeed it is likely that there is a combination of specialized and distributed processing in the brain [182–187]. This is depicted for various forms of memory processing in Figure 7. It is assumed at present that there are specialized regions for sensory and perceptual processing, encoding (short-term memory) and consolidation (limbic system; [11, 13]), storage (widespread cortical nets), and retrieval (temporofrontal cortical regions) of information.
Bilateral brain damage to structures of the limbic system [13, 188] leads to massive impairments in anterograde memory processing, both on the semantic and episodic autobiographical level [189–191]. This was found long ago with the advent of the Korsakoff’s syndrome [192–199] and continued with the finding that hippocampal damage leads to amnesia  which, however, as published in German language, was not recognized internationally and therefore resulted in bilateral resection of this and related medial temporal lobe structures by Scoville and Milner  with the consequence of lifelong anterograde amnesia [189, 202, 203]. At present, much research performed both on patients with hippocampal damage (as, e.g., in neurodevelopmental amnesia [204–208], but also in patients with other etiologies [209–213]) and in normal subjects with functional brain imaging [23, 214–225] tries to reveal the specific role of the hippocampal formation (or of portions of it) in long-term memory processing. Recently, it was proposed that the hippocampal formation might also be engaged in some forms of nonconscious memory [226–229], in working memory [230, 231] and spatial memory [232–236]. Furthermore there is evidence that exercise enlarges hippocampal volume and improves memory performance [237–239] and that the hippocampal formation is engaged in sleep-related memory consolidation [240, 241].
Coming back to the question from above on localization versus antilocalization of brain functions , Quian Quiroga  promoted the idea of a compromise which is, however, inclined towards the direction of a close localization of function. Based on earlier research in the medial temporal lobe [243–246] he proposed that there are concept cells in the medial temporal, particularly the hippocampal formation, neurons that respond in a selective and abstract manner towards persons (faces) or objects. Quian Quiroga  proposed that small assemblies of such neurons fire distinctly to the representation of a person or an object. Furthermore he argued similarly to the idea of previous researchers [184, 186, 187] that individual neurons of such an assembly may be engaged in the representation of similar (i.e., easily associable) objects or persons. In this way they do not represent “grandmother cells” in the traditional way proposed about 50 years ago but are still rather distinct agglomerates of neurons representing a single item. Figure 8 demonstrates how these assemblies are distinct but nevertheless overlapping with respect to related representations (such as tiger, lion, and cheetah).
6.1. Information Consolidation and the Limbic System
Since the end of the 20th century, scientists proposed a special role of limbic system structures in information encoding and consolidating for long-term storage . These ideas originated from a number of single case reports of patients with bilateral damage to various structures of the limbic system, especially of the diencephalon [200, 248–258]. In 1937, Papez  published an influential paper on “A proposed mechanism of emotion” in which he suggested that interconnections between several limbic structures are necessary for a proper processing of emotions. His suggestion was later taken up and this circuit or modifications of it were proposed as essential for memory transfer for long-term storage [260, 261].
Indeed, numerous evidence from the last decades confirms the importance of structures such as the anterior and mediodorsal thalamus and the mammillary bodies [262–273], diencephalic fiber tracts [274, 275], the fornix [276–279], the (posterior) cingulate/retrosplenial cortex , the amygdala [18, 281–289], and the basal forebrain/septal nuclei [290–292] (aside from the hippocampal formation and surrounding medial temporal cortex mentioned already above). After Papez  Livingston and Escobar  suggested another circuit within these structures—the basolateral limbic circuit. Cum grano salis, it can be stated that the Papez circuit is more important for fact-based information and the basolateral limbic circuit for affect-based information. Both interact and are directly interconnected (Figure 9).
As brain lesions are rarely confined to one nucleus, and as the limbic structures are especially heavy interconnected , structures of both circuits are usually damaged. Korsakoff’s amnesia usually affects medial thalamic structures and the mammillary bodies within the hypothalamus . Bonhoeffer already in 1901  characterized patients with Korsakoff’s syndrome as having major anterograde amnesia, retrograde memory defects, disorientation, and confabulatory tendencies. These cardinal symptoms (as Bonhoeffer termed them) of the usually alcohol-abuse-related disease are still valid today. Impairments in consuming and metabolizing vitamin B1 apparently lead to the characteristic brain degenerations in the diencephalon. Intelligence can be largely preserved in Korsakoff’s amnesics.
Also in other diencephalic etiologies as in infarct patients, intelligence is unaffected after bilateral damage to structures such as the mediodorsal nucleus, the mammillothalamic tract and the medial internal lamina (containing thalamocortical fibers . Markowitsch et al.  even emphasized in the title of their publication that the patient had “preserved intelligence and severe amnesic disturbances.” Furthermore, he usually was unconscious of his amnesia and tended to confabulate. In this way this diencephalically damaged patient differed from the medial temporal lobe-damaged patient H.M. [189, 202, 203, 296] of whom the following statement was passed on: “every day is alone, whatever enjoyment I’ve had, and whatever sorrow I’ve had” [296, page 217]. The impairment of our diencephalic patient with respect to conscious self-reflection is in accordance with Dercum’s  hypothesis that the thalamus is necessary for consciousness, proposed nearly ninety years ago. Dercum  attributed consciousness to the fibers ascending from the thalamus to the cortex (page 293). As the thalamus would be the seat of all sensations, perceptions, feelings, and emotions, its activity is necessary for safety, success, and well-being of the organism (page 294). This idea was later confirmed by the findings of other authors . Recently, Philippi and coworkers  did an extensive case analysis of a patient with severe nonthalamic damage after a severe episode of herpes simplex encephalitis; they found that while his autobiographical or extended self was at least partially affected by the extensive bilateral damage of insula, anterior cingulate, and medial prefrontal cortices, his core self-awareness (including self-recognition and the sense of self-agency) appeared preserved.
Within the basolateral limbic circuit (cf. Figure 9) the amygdala or amygdaloid complex constitutes a major hub for processing emotional material and providing connotations to new incoming material. In fact the amygdala receives preprocessed information from all sensory modalities and analyzes the social and biological significance for the self . Amygdala damage usually occurs in relation to encephalitis and is nonselective in this condition. There exists, however, a rare disease condition which leads to selective bilateral degeneration (calcification) of the two amygdalae, the Urbach-Wiethe disease. Urbach-Wiethe disease primarily is a dermatological disease condition which, however, in most cases leads in adulthood to amygdala calcification. In the United States of America, there is especially the patient SM who has been studied extensively with respect to deficits resulting from this disease [299–306]. In Europe and South Africa larger numbers of patients with Urbach-Wiethe disease were studied in recent years [18, 20, 282, 285–287, 307, 308].
Common to these reports is the fact that patients with selective bilateral amygdala damage show alterations in identifying what is usually of social and emotional significance, though there is a wide range of interindividual variation [285–287, 307–310]. Also specific form of social—such as altruistic—behavior is altered . The patients appear less sure about their judgments, have olfactory disturbances, and appear with insufficient distance when approaching others [18, 20]. Fear is reduced in them . Interestingly, memory is affected both during learning and recall [285–287, 311, 312] as the patients have difficulty in distinguishing relevant from irrelevant information. Consequently, the amygdala has an important impact on memory processing, especially on episodic autobiographical memory [311–317]. Mayford et al.  exemplified this for fear memory and synaptic changes in the amygdala and we  have argued “that the amygdala is not simply an emotional brain structure but integrates emotion with cognition” (page 166). As shown in Figure 1 of Markowitsch and Staniloiu , we have a somewhat similar approach as Quian Quiroga (cf. Figure 8) by assuming that networks of single neurons, engaged in different aspects of information processing (such as in arousal and activation, representation, and affect coding), are necessary for successful self-reflected information retrieval. With the example of 9/11, Sharot et al.  have demonstrated with functional brain imaging that the amygdala enhances personal-relevance-related activity during the recall of a frightening event.
6.2. Information Storage and the Cerebral Cortex
As Figure 7 indicates, the cerebral cortex is considered to be the main storage area for mnestic information. This hypothesis comes from calculation models of its neuronal capacity [319, 320], from evidence from patients with large-scale [321, 322] degeneration of cortical structures [323, 324], and from models of information storage in neural structures [185–187]. Furthermore, lesion research in patients provides some evidence for modularity of memory storage in cortical regions [325–328]. Especially, however, two streams of research provide evidence for widespread cortical storage: for one, evidence from patients with conditions after severe hypoxia  and dementia-related cortical degeneration  with severe anterograde and retrograde amnesia reinforces the view that the cerebral cortex is the principal storage place for consciously processed information. Secondly, the idea that the synchrony of cortical oscillations serves as a binding phenomenon for memory [329–332]. This synchrony might be promoted by thalamocortical interaction .
6.3. Information Retrieval and the Temporo-Frontal Cortex
When it comes to the retrieval of consciously processed information, we in 1993 studied a patient with traumatic brain injury of mainly the right temporo-frontal cortex with some less severe contrecoup damage to the respective region of the left hemisphere . The patient had complete retrograde amnesia in the episodic autobiographical domain. However, he was able to learn new information in long-term and he had partly preserved semantic memory, together with fully preserved skills (procedural memory). A few years later we and others found several patients with similar brain damage and a similar inability to retrieve personal events from the past [160, 161, 335, 336]. Vice versa, others and we observed that patients with mainly left hemispheric damage to the same regional combination—which is interconnected bidirectionally by the uncinate fascicle, a fiber tract which seems to grow or increase in size beyond the age of 30 years —had an inability to retrieve past semantic memories [163, 338]. The patient of De Renzi et al.  was a 44-year-old school teacher with herpes encephalitis affecting her left anteromedial inferior temporal lobe. She had preserved autobiographical memories and a preservation of grammar and syntax rules but seemed to have forgotten all her world knowledge as tested, for example, with famous names (e.g., Moro, Mussolini, Stalin, Kaddafyi, Hitler, Mozart, Wagner, Garibaldi, Greta Garbo, and Dante). Also recipes for cooking (e.g., spaghetti) had been lost.
We confirmed the importance of the right temporo-frontal cortex for retrieval with functional brain imaging (positron emission tomography) by studying autobiographical memory retrieval of young normal participants . Again, we observed that retrieval of these events activated largely the right hemispheric temporo-frontal cortex. Our findings were taken up in a review on “Cognitive neuroscience of emotional memory” by LaBar and Cabeza  who wrote on page 59 “studies of retrograde amnesia support Markowitsch’s proposal that retrieval of remote personal memories involves interactions between the inferior PFC (prefrontal cortex) and its connections with the anteromedial temporal lobe that course through the uncinate fasciculus.” It is at present undecided whether the damage of the temporo-frontal region indeed causes retrograde amnesia in the way that there is no longer access to the probably more posteriorly in the temporal lobe and other cortical-areas-situated old memories, or whether the damage (which frequently occurs via traumatic brain injury) triggers a psychogenic reaction that disrupts conscious access to old memories [cf. [340, 341]]. If the second mechanism were correct, it would still be difficult to interpret the selective semantic amnesia in cases with left hemispheric damage. The right hemisphere has been considered to be more intimately involved in emotional processing  which would speak in favor of the episodic autobiographical amnesia after its damage. Of importance is that the self of the patient is considerably disturbed as he or she no longer has access to his or her personal past or to significant portions of it (at least in cases with right hemispheric damage). The same phenomenon occurs in patients with dissociative or psychogenic amnesia and will be discussed in the next section.
7. Memory Distortions and Impairments in Psychiatry
That memory disturbances can occur without overt brain damage has been known already in the 19th century (and very likely before) . Goldsmith et al.  pointed out that Pliny the Elder (23–79 A.D.) already had talked about “fright” as being one of the causes of partial or total memory loss. The end of the 19th century brought a major impetus in diagnosing patients as having “hysteria” [344–351] and a new wave in diagnosing this condition came with the First World War . Nowadays we have various overlapping terms to describe the symptomatology of amnesic conditions without concomitant brain damage: “psychogenic amnesia” , “dissociative amnesia” , “functional amnesia” [95, 355–358], and “mnestic block syndrome” [164–169] are expressions used partly interchangeably, though there are of course differences between them. “Functional amnesia” implies that the amnesia has a function for the affected—it is a more neutral term and can include patients with and without additional (manifest) brain damage. “Dissociative amnesia” is the term used in DSM IV-TR  to describe a syndrome where the patient is unable to recall important personal information, usually of a traumatic or stressful nature. The amnesia goes beyond normal forgetfulness but cannot be related to brain damage or the effects of drug consumption. The symptoms cause significant distress or impairment in occupational, social, or other important areas of functioning. “Psychogenic amnesia” is largely overlapping with “dissociative amnesia”; it also emphasizes the psychic and stress-related nature of the disease as well as the occurrence of retrograde amnesia. The term “mnestic block syndrome” emphasizes that the memory loss may be reversible and that just the conscious access to them may be blocked. Even anterograde amnesia of a psychic origin was reported [360, 361]. Long-term followups of such persons are rarely published; probably the 19-year followup we did with a former law student who is anterogradely amnesic since 1994 is the longest . It is known that patients with long-term amnesia deteriorate also intellectually, as they have reduced intellectual stimulation and do not memorize new information properly. It is therefore of interest to do long-term followups with both retrogradely and anterogradely amnesic patients with a psychogenic background in order to find out whether they in any way might be more prone to developing dementia than subjects with normal memory conditions .
In the last years we investigated a considerable number of patients with these and closely related forms of amnesia [120, 165, 167, 356, 363–369]. For all cases we performed an intensive neuropsychological investigation and usually we also did static and functional neuroimaging with them. Fluoro-deoxy-D-glucose positron emission tomographic (PET) investigations were done to obtain evidence for possible metabolic changes in their cerebrum; water PET was used to determine brain changes in relation to memory. By combining the PET results from 14 of such patients  we found that in principal the same brain region—namely, the temporo-frontal cortex of the right hemisphere—was reduced in glucose metabolism which was highly active when normal subjects recalled their autobiographical memories . This finding suggests that if it would be possible to stimulate the right temporo-frontal cortex either via psychotherapy or via transcranial magnetic stimulation (or even by deep brain stimulation), personal memories might be reinstated.
Interesting features of our patients were–aside from their memory blockade as follows: (i) an increased susceptibility and personal lability,(ii) “belle indifference” and lack of effort,(iii) identity loss and character changes.
Most of the patients already most likely prior to the onset of the dissociative amnesic condition were particularly susceptible to arguments and opinions of others and were easily directed to change their habits. Patient NN of Mar-ko-witsch et al.  followed the suggestion of a person from the Salvation Army to enter a psychiatric hospital. He also followed the suggestion of his friend to take her last name also as his new last name after marriage. NN also did not object to his wife to take vacation with the family in spite of the lack of money. He also immediately followed the advice of homeless people to enter the main station of a large city. Furthermore, he was influenced by another patient during his psychiatric stay to change his profession and try to become owner (together with the other patient) of a restaurant. The patient described by Markowitsch et al.  throughout his life appeared to act only after the will of his mother and, later, of his wife. The mother suggested to him what he should study, the wife pushed him early in his career to establish an own firm and to buy a house.
The majority of our patients were principally indifferent towards their disease. Most of them refused therapeutic interventions and appeared even satisfied with their new life situation. The patient described in Markowitsch et al.  lives since onset of her amnesia in 1994 in a small apartment together with her old mother without trying to leave the house or to meet other people. She just stays with her computer and walks from time to time through portions of the nearby park. We had noted a similar condition with significant and lasting lack of effort with respect to the own condition in several other patients, including a former medical doctor (who developed a compulsive hoarding syndrome), who remained in their life condition in spite of numerous attempts from the environment to change their situation. This symptomatology was also found in a patient without identity loss .
Identity loss is the most significant and most frequent concomitant of dissociative amnesic states. The patient no longer knows who she or he was, who his or her partner and children are and has no clue about his or her past emotional behavior (e.g., with respect to intimacy with the partner). Patients, for example, also describe that they do not any more recognize her face in a mirror [120, 368] (a finding described since long) . Patient NN of Markowitsch et al.  changed his life habits: before his amnesia he was an avid car driver, afterwards he considered cars as too fast for human beings and avoided sitting in them. He also changed his diet and eating habits.
Also direct somatic changes were observed: patient NN  after amnesia onset lost his asthma and allergy. Another patient, who had been accused of raping a female, lost his ability to urinate and had to be catheterized by his wife during day and night time .
Interestingly, many of such changes, affecting self-consciousness and self-awareness, were already noted in the frequently painstakingly careful descriptions of the old days (e.g., [345, 346, 348, 374–376]), though sometimes different expressions were used. Interesting is, for instance the frequently used term of “double consciousness” [377–380], which partly reflects the general dissociation in mental state and partly the possible occurrence of dissociative identity disorders. Even in the belletristic literature of that time (or half a century earlier) reference was made to phenomena resembling dissociative states and depersonalization [381, 382].
Already in 1906 Gordon  stated that “self-consciousness is a conditio sine qua non of normal life” (page 480) and that amnesia is the most typical of all disturbances of consciousness. Both cases in the old literature as well as some of our recently studied patients show very similar changes after onset of their “mnestic block syndrome”. Dana  described in 1874 a 24-year-old “active, intelligent, and healthy… man” (page 571). Due to carbon monoxide poisoning by domestic gas, his behavior changed. After been rescued, he was quite disturbed and “did not know who he was or where he was, and… his conscious memory for everything connected with his past life was gone” (page 572). His behavioral changes included the use and understanding of only the simplest words. After realizing where he was he “pronounced many of the new words with a German accent” (page 572), similar to the way his German attendant spoke. He did not know what marriage meant and did not remember (previously) familiar persons though he seemed especially glad to see them. At first he was unable to read but soon learned to read and write simple sentences. Old musical memories existed and so did habits connected with courtesy.
Interestingly, “in argument he showed considerable dialectic skill and logical power, [but] he evidently could not understand any conceptions at all abstract” (page 573). “The moon, the stars, the animals, his friends, all were mysteries he impatiently hastened to solve” (page 574). While at the beginning he did not recognize his parents or sisters, or his fiancée, from the beginning he said that he had always known her and subsequently his thoughts and feelings centered on her.
Exactly three months after his attack, his memory was completely restored. The recovery started during a visit in the evening at his fiancée’s; she thought he was in a condition worse than during the previous months and said “he felt as though one half of his head was prickling and numb, then the whole head, then he felt sleepy and was very quiet… At about 11 o’clock he woke up and found his memory restored… He knew all his family at once and was plainly just the same man as before. But the three months was an entire blank to him.” (page 575). So he did not know Professor Dana whom he had not seen before the accident.
While such an abrupt and nearly complete memory restoration, the total but time-limited loss of knowledge about his family and friends, and the age of the patient all favor psychogenic amnesia, the carbon monoxide poisoning provides a basis for an organic damage-based explanation, possibly the poisoning, but triggered the release or manifestation of an already existing tendency for psychogenic memory loss.
Our recently investigated patient with complete retrograde amnesia in the episodic autobiographical domain and an additional brain glioma was a 29-year-old male . He had a several-week history of gait disturbances, headaches, and intermittent problems with his vision. A medulloblastoma occupying the fourth ventricle was diagnosed and subsequently completely removed surgically. Postoperatively the patient did not recognize his friends, his grandmother, and even himself in pictures from his youth. He only recognized his parents and his brother. He forgot the profession of his father. He did not know the names of his acquaintances, friends, or former colleagues anymore. He did not know which professional training or job he had had. He did not recall that fishing used to be his hobby. Furthermore he did not know how to use a fishing rod. He encountered considerable difficulties with naming objects. He perceived his situation as if he stood in a white room, where the door behind him had been locked and he did not know where he had come from. Tests of anterograde memory were in the normal range or even above average. His past history revealed that he had been adopted after birth and had received treatment in childhood for difficulties with concentration and a delay in language development. At the age of 26 years the patient was diagnosed with a testicular carcinoma, which was completely surgically removed, and also treated with both chemotherapy and radiation therapy; he had had several other diseases of the scrotum when he was a child.
Similarly to Dana’s patient this case is a prototypical illustration of the complex interplay between organic and psychogenic mechanisms that underlies several cases of retrograde amnesia. These cases have often been listed under the diagnostic construct of functional amnesia.
Functional amnesias demonstrate to what degree the environment can shape the nervous system. An adverse environment can alter the brain’s metabolism and—in the longer run—lead to structural changes. The science of epigenetics provides a convincing basis for such an interplay [73–88]. An example from neurology is transient global amnesia, a condition of sudden memory loss.
8. Brain, Memory, and Self
Both the case descriptions of patients with an organic and with a psychogenic basis of their memory loss reveal that memory is an essential attribute of our well-being and our personality. Memory allows capturing the world in space and time and to mentally travel into various epochs of one’s past life. In addition it allows “proscopic chronesthesia”—the forward-looking sense of subjective time . Anterograde amnesia leaves the patient “frozen in time”—he or she can no longer acquire emotionally colored information which would allow adapting towards new circumstances. Retrograde amnesia on the other hand leaves a person without grounding, without orientation on his or her background. There is no reference available for being similar to or different from others.
Patients with memory loss have deficits with respect to their possibilities of self-reflection and personal temporality [385–387]; other attributes such as self-agency and self-ownership can be seen as largely preserved. Klein  recently argued that there are several episodic memory enabling systems—ownership, self, subjective temporality, and agency—which are necessary for episodic autobiographical recollection. Vice versa, one can argue that an impairment in episodic autobiographical recollection, whether due to overt damage of neural tissue or whether due to stress-related glucocorticoid (stress hormone) release, can retroactively affect the self.
Self and episodic autobiographical are dynamic processes, shaped over the life time by the ups and downs of brain development (myelination, pruning, sexual dimorphism, neurogenesis, synaptogenesis, vessel growth, and regression) [389–398], the social-cultural influences on brain and self over time [399–402], and especially during aging [403–405]. As our brain differs across life time, our self changes as well. We may not (always) be aware of these changes, as we cannot monitor our self from an external point of view. Nevertheless, we can observe and test such changes by viewing others. And above all, brain damage—whether focal [19–23, 26, 27, 406] or extensive (degenerative or diffuse) [407–410]—makes such changes visible even to the layperson.
There is evidence from comparative biological , clinical neurological , and memory research [2, 4] that the complex interplay of self and brain can be altered at many levels (including drug application [411, 412]). We still have only begun to unravel the brain processes responsible for memory consolidation [413–416], storage, and retrieval [242, 417, 418]. All the more we are only starting to disclose relations between brain and mind [3, 6, 419–421].
- M. A. Conway, “Memory and the self,” Journal of Memory and Language, vol. 53, no. 4, pp. 594–628, 2005.
- S. B. Klein and C. E. Gangi, “The multiplicity of self: neuropsychological evidence and its implications for the self as a construct in psychological research,” Annals of the New York Academy of Sciences, vol. 119, pp. 1–15, 2010.
- T. Metzinger, “Empirical perspectives from the self-model theory of subjectivity: a brief summary with examples,” Progress in Brain Research, vol. 168, pp. 215–278, 2007.
- C. J. Rathbone, C. J. A. Moulin, and M. A. Conway, “Autobiographical memory and amnesia: using conceptual knowledge to ground the self,” Neurocase, vol. 15, no. 5, pp. 405–418, 2009.
- G. Northoff and J. Panksepp, “The trans-species concept of self and the subcortical-cortical midline system,” Trends in Cognitive Sciences, vol. 12, no. 7, pp. 259–264, 2008.
- A. R. Sutin and R. W. Robins, “When the “I” looks at the “Me”: autobiographical memory, visual perspective, and the self,” Consciousness and Cognition, vol. 17, no. 4, pp. 1386–1397, 2008.
- S. Klein, “The Two Selves: the self of conscious experience and its brain,” in Handbook of Self and Identity, M. R. Leary and J. P. Tangney, Eds., Guilford, New York, NY, USA, 2nd edition, 2013.
- E. Hering, Ueber das Gedächtnis als Eine Allgemeine Funktion der Organisierten Materie. Vortrag Gehalten in der Feierlichen Sitzung der Kaiserlichen Akademie der Wissenschaften in Wien am XXX. Mai MDCCCLXX, Akademische Verlagsgesellschaft, Leipzig, German, 1870.
- E. Hering, Memory as a General Function of Organized Matter, Open Court, Chicago, UK, 1895.
- S. Arzy, S. Collette, S. Ionta, E. Fornari, and O. Blanke, “Subjective mental time: the functional architecture of projecting the self to past and future,” European Journal of Neuroscience, vol. 30, no. 10, pp. 2009–2017, 2009.
- A. Brodal, “The hippocampus and the sense of smell: a review,” Brain, vol. 70, no. 2, pp. 179–222, 1947.
- J. Willander and M. Larsson, “Smell your way back to childhood: autobiographical odor memory,” Psychonomic Bulletin and Review, vol. 13, no. 2, pp. 240–244, 2006.
- H. J. Markowitsch, “Limbic system,” in The MIT Encyclopedia of the Cognitive Sciences, R. Wilson and F. Keil, Eds., pp. 472–475, MIT Press, Cambridge, Mass, USA, 1999.
- P. D. MacLean, “The triune brain, emotion, and the scientific bias,” in The Neurosciences: Second Study Program, F. O. Schmitt, Ed., pp. 336–349, Rockefeller University Press, New York, NY, USA, 1970.
- P. D. MacLean, “Cerebral evolution and emotional processes: new findings on the striatal complex,” Annals of the New York Academy of Sciences, vol. 193, pp. 137–149, 1972.
- P. D. Maclean, “Evolutionary psychiatry and the triune brain,” Psychological Medicine, vol. 15, no. 2, pp. 219–221, 1985.
- J. Ledoux, The Emotional Brain, Touchstone, New York, NY, USA, 1998.
- H. J. Markowitsch and A. Staniloiu, “Amygdala in action: relaying biological and social significance to autobiographical memory,” Neuropsychologia, vol. 49, no. 4, pp. 718–733, 2011.
- L. Cahill, R. Babinsky, H. J. Markowitsch, and J. L. McGaugh, “The amygdala and emotional memory,” Nature, vol. 377, no. 6547, pp. 295–296, 1995.
- M. Siebert, H. J. Markowitsch, and P. Bartel, “Amygdala, affect and cognition: evidence from 10 patients with Urbach-Wiethe disease,” Brain, vol. 126, no. 12, pp. 2627–2637, 2003.
- J. S. Feinstein, M. C. Duff, and D. Tranel, “Sustained experience of emotion after loss of memory in patients with amnesia,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 17, pp. 7674–7679, 2010.
- J. S. Feinstein, R. Adolphs, A. Damasio, and D. Tranel, “The human amygdala and the induction and experience of fear,” Current Biology, vol. 21, no. 1, pp. 34–38, 2011.
- H. J. Markowitsch and S. Staniloiu, “Amnesic disorders,” The Lancet, vol. 380, no. 9851, pp. 1429–1440, 2012.
- W. J. H. Nauta, “Expanding borders of the limbic system concept,” in Functional Neurosurgery, T. Rasmussen and R. Marino, Eds., pp. 7–23, Raven Press, New York, NY, USA, 1979.
- R. Nieuwenhuys, “The greater limbic system, the emotional motor system and the brain,” Progress in Brain Research, vol. 107, pp. 551–580, 1996.
- D. Y. von Cramon, H. J. Markowitsch, and U. Schuri, “The possible contribution of the septal region to memory,” Neuropsychologia, vol. 31, no. 11, pp. 1159–1180, 1993.
- H. J. Markowitsch, D. Y. von Cramon, and U. Schuri, “Mnestic performance profile of a bilateral diencephalic infarct patient with preserved intelligence and severe amnesic disturbances,” Journal of Clinical and Experimental Neuropsychology, vol. 15, no. 5, pp. 627–652, 1993.
- R. L. Buckner, “The serendipitous discovery of the brain’s default network,” Neuroimage, vol. 62, pp. 1137–1145, 2012.
- R. L. Buckner, J. R. Andrews-Hanna, and D. L. Schacter, “The brain's default network: anatomy, function, and relevance to disease,” Annals of the New York Academy of Sciences, vol. 1124, pp. 1–38, 2008.
- A. A. Fingelkurts and A. A. Fingelkurts, “Persistent operational synchrony within brain default-mode network and self-processing operations in healthy subjects,” Brain and Cognition, vol. 75, no. 2, pp. 79–90, 2011.
- R. L. Buckner and D. C. Carroll, “Self-projection and the brain,” Trends in Cognitive Sciences, vol. 11, no. 2, pp. 49–57, 2007.
- H. J. Markowitsch, “Time, memory, and consciousness. A view from the brain,” in Endophysics, Time, Quantum, and The Subjective, R. Buccheri, A. C. Elitzur, and M. Saniga, Eds., pp. 131–147, World Scientific, Singapore, 2005.
- L. Kvavilashvili, D. J. Messer, and P. Ebdon, “Prospective memory in children: the effects of age and task interruption,” Developmental Psychology, vol. 37, no. 3, pp. 418–430, 2001.
- R. G. Benoit, S. J. Gilbert, E. Volle, and P. W. Burgess, “When I think about me and simulate you: medial rostral prefrontal cortex and self-referential processes,” NeuroImage, vol. 50, no. 3, pp. 1340–1349, 2010.
- S. J. Carrington and A. J. Bailey, “Are there theory of mind regions in the brain? A review of the neuroimaging literature,” Human Brain Mapping, vol. 30, no. 8, pp. 2313–2335, 2009.
- R. N. Spreng and C. L. Grady, “Patterns of brain activity supporting autobiographical memory, prospection, and theory of mind, and their relationship to the default mode network,” Journal of Cognitive Neuroscience, vol. 22, no. 6, pp. 1112–1123, 2010.
- K. Nelson and R. Fivush, “The emergence of autobiographical memory: a social cultural developmental theory,” Psychological Review, vol. 111, no. 2, pp. 486–511, 2004.
- R. Fivush, “The development of autobiographical memory,” Annual Review of Psychology, vol. 62, pp. 559–582, 2011.
- G. Northoff, “Self and brain: what is self-related processing?” Trends in Cognitive Sciences, vol. 15, no. 5, pp. 186–187, 2011.
- M. Vandekerckhove and J. Panksepp, “A neurocognitive theory of higher mental emergence: from anoetic affective experiences to noetic knowledge and autonoetic awareness,” Neuroscience and Biobehavioral Reviews, vol. 35, no. 9, pp. 2017–2025, 2011.
- C. Sebastian, S. Burnett, and S. J. Blakemore, “Development of the self-concept during adolescence,” Trends in Cognitive Sciences, vol. 12, no. 11, pp. 441–446, 2008.
- C. L. Sebastian, N. M. Fontaine, G. Bird, et al., “Neural processing associated with cognitive and affective Theory of Mind in adolescents and adults,” Social, Cognitive and Affective Neuroscience, vol. 7, no. 1, pp. 53–63, 2012.
- S. Oddo, S. Lux, P. H. Weiss et al., “Specific role of medial prefrontal cortex in retrieving recent autobiographical memories: an fMRI study of young female subjects,” Cortex, vol. 46, no. 1, pp. 29–39, 2010.
- C. Sebastian, E. Viding, K. D. Williams, and S. J. Blakemore, “Social brain development and the affective consequences of ostracism in adolescence,” Brain and Cognition, vol. 72, no. 1, pp. 134–145, 2010.
- S. Burnett, C. Sebastian, K. Cohen Kadosh, and S. J. Blakemore, “The social brain in adolescence: evidence from functional magnetic resonance imaging and behavioural studies,” Neuroscience and Biobehavioral Reviews, vol. 35, no. 8, pp. 1654–1664, 2011.
- F. Homae, H. Watanabe, T. Nakano, and G. Taga, “Large-scale brain networks underlying language acquisition in early infancy,” Frontiers in Psychology, vol. 2, article 93, pp. 1–14, 2011.
- S. A. Josselyn and P. W. Frankland, “Infantile amnesia: a neurogenic hypothesis,” Learning & Memory, vol. 19, pp. 423–433, 2012.
- B. K. Cheon, D.-M. Im, T. Harada et al., “Cultural influences on neural basis of intergroup empathy,” NeuroImage, vol. 57, no. 2, pp. 642–650, 2011.
- M. Chudek and J. Henrich, “Culture-gene coevolution, norm-psychology and the emergence of human prosociality,” Trends in Cognitive Sciences, vol. 15, no. 5, pp. 218–226, 2011.
- L. Picard, I. Reffuveille, F. Eustache, and P. Piolino, “Development of autonoetic autobiographical memory in school-age children: genuine age effect or development of basic cognitive abilities?” Consciousness and Cognition, vol. 18, no. 4, pp. 864–876, 2009.
- K. A. Willoughby, M. Desrocher, B. Levine, and J. F. Rovet, “Episodic and semantic autobiographical memory and everyday memory during late childhood and early adolescence,” Frontiers in Psychology, vol. 3, article 53, pp. 1–15, 2012.
- N. Davis, J. Gross, and H. Hayne, “Defining the boundary of childhood amnesia,” Memory, vol. 16, no. 5, pp. 465–474, 2008.
- I. Harpaz-Rotem and W. Hirst, “The earliest memory in individuals raised in either traditional and reformed kibbutz or outside the kibbutz,” Memory, vol. 13, no. 1, pp. 51–62, 2005.
- Q. Wang, “Culture effects on adults' earliest childhood recollection and self-description: implications for the relation between memory and the self,” Journal of Personality and Social Psychology, vol. 81, no. 2, pp. 220–233, 2001.
- C. Peterson, Q. Wang, and Y. Hou, “‘when i was little’: childhood recollections in chinese and european canadian grade school children,” Child Development, vol. 80, no. 2, pp. 506–518, 2009.
- Q. Wang, “Emotion knowledge and autobiographical memory across the preschool years: a cross-cultural longitudinal investigation,” Cognition, vol. 108, no. 1, pp. 117–135, 2008.
- H. J. Markowitsch and A. Staniloiu, “Memory, autonoetic consciousness, and the self,” Consciousness and Cognition, vol. 20, no. 1, pp. 16–39, 2011.
- Y. Zhu, L. Zhang, J. Fan, and S. Han, “Neural basis of cultural influence on self-representation,” NeuroImage, vol. 34, no. 3, pp. 1310–1316, 2007.
- C. L. Philippi, J. S. Feinstein, S. S. Khalsa, et al., “Preserved self-awareness following extensive bilateral brain damage to the insula, anterior cingulate, and medial prefrontal cortices,” PLoS ONE, vol. 7, no. 8, Article ID e38413, 2012.
- B. C. Campbell and J. R. Garcia, “Neuroanthropology: evolution and emotional embodiment,” Frontiers in Evolutionary Neuroscience, vol. 1, article1, pp. 1–6, 2012.
- R. Pfeife and J. Bongard, How the Body Shapes the Way we Think. A New View of Intelligence, MIT Press, Cambridge, Mass, USA, 2007.
- G. G. Gallup, “Chimpanzees: self-recognition,” Science, vol. 167, no. 3914, pp. 86–87, 1970.
- J. M. Plotnik, F. B. M. De Waal, and D. Reiss, “Self-recognition in an Asian elephant,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 45, pp. 17053–17057, 2006.
- P. Rochat,, T. Broesch, K. Jayne, et al., “Social awareness and early self-recognition,” Consciousness and Cognition, vol. 21, no. 3, pp. 1491–1497, 2012.
- D. L. Butler, J. B. Mattingley, R. Cunnington, and T. Suddendorf, “Mirror, mirror on the wall, how does my brain recognize my image at all?” PLoS ONE, vol. 7, no. 2, Article ID e31452, 2012.
- A. R. Damasio, “The Feeling of What Happens: Body, Emotion and the Making of Consciousness,” Psyche, Vintage, London, UK, 2000.
- E. Tulving, “Episodic memory and autonesis: uniquely human?” in The Missing Link in Cognition: Evolution of Self-Knowing Consciousnes, H. Terrace and J. Metcalfe, Eds., pp. 3–56, Oxford University Press, New York, NY, USA, 2005.
- E. Tulving, “Episodic memory: from mind to brain,” Annual Review of Psychology, vol. 53, pp. 1–25, 2002.
- T. Suddendorf and M. C. Corballis, “Mental time travel and the evolution of the human mind,” Genetic, Social, and General Psychology Monographs, vol. 123, no. 2, pp. 133–167, 1997.
- T. Suddendorf, D. R. Addis, and M. C. Corballis, “Mental time travel and the shaping of the human mind,” Philosophical Transactions of the Royal Society B, vol. 364, no. 1521, pp. 1317–1324, 2009.
- W. A. Roberts and M. C. Feeney, “The comparative study of mental time travel,” Trends in Cognitive Sciences, vol. 13, no. 6, pp. 271–277, 2009.
- R. Sinz, Neurobiologie und Gedächtnis, Gustav Fischer, Stuttgart, Germany, 1979.
- T. Kubota, K. Miyake, and T. Hirasawa, “Epigenetic understanding of gene-environment interactions in psychiatric disorders: a new concept of clinical genetics,” Clinical Epigenetics, vol. 4, no. 1, article 1, pp. 1–2, 2012.
- K. Huffman, “The developing, aging neocortex: how genetics and epigenetics influence early developmental patterning and age-related change,” Frontiers in Genetics, vol. 3, article 212, pp. 1–11, 2012.
- C. Mugatroyd and D. Spengler, “Epigenetics of early child development,” Frontiers in Psychiatry, vol. 2, article16, pp. 1–15, 2011.
- I. C. G. Weaver, N. Cervoni, F. A. Champagne et al., “Epigenetic programming by maternal behavior,” Nature Neuroscience, vol. 7, no. 8, pp. 847–854, 2004.
- I. C. G. Weaver, F. A. Champagne, S. E. Brown et al., “Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life,” Journal of Neuroscience, vol. 25, no. 47, pp. 11045–11054, 2005.
- T. F. Oberlander, J. Weinberg, M. Papsdorf, R. Grunau, S. Misri, and A. M. Devlin, “Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses,” Epigenetics, vol. 3, no. 2, pp. 97–106, 2008.
- T. B. Franklin, H. Russig, I. C. Weiss et al., “Epigenetic transmission of the impact of early stress across generations,” Biological Psychiatry, vol. 68, no. 5, pp. 408–415, 2010.
- K. M. Radtke, M. Ruf, H. M. Gunter et al., “Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor,” Translational Psychiatry, vol. 1, article e21, 2011.
- B. M. Turner, “Defining an epigenetic code,” Nature Cell Biology, vol. 9, no. 1, pp. 2–6, 2007.
- S. McClelland, A. Korosi, J. Cope, A. Ivy, and T. Z. Baram, “Emerging roles of epigenetic mechanisms in the enduring effects of early-life stress and experience on learning and memory,” Neurobiology of Learning and Memory, vol. 96, no. 1, pp. 79–88, 2011.
- K. M. Lattal and M. A. Wood, “Epigenetics and persistent memory: implications for reconsolidation and silent extinction beyond zero,” Nature Neuroscience, vol. 16, no. 2, pp. 124–129, 2013.
- M. Penner, T. L. Roth, C. A. Bames, and J. D. Sweatt, “An epigenetic hypothesis of aging-related cognitive dysfunction,” Aging Neuroscience, vol. 2, article 9, 2010.
- J. Gräff and I. M. Mansuy, “Epigenetic dysregulation in cognitive disorders,” European Journal of Neuroscience, vol. 30, no. 1, pp. 1–8, 2009.
- S. Peleg, F. Sananbenesi, A. Zovoilis et al., “Altered histone acetylation is associated with age-dependent memory impairment in mice,” Science, vol. 328, no. 5979, pp. 753–756, 2010.
- J.-D. Sweatt, “Epigenetics and cognitive aging,” Science, vol. 328, no. 5979, pp. 701–702, 2010.
- T. L. Roth and J. D. Sweatt, “Regulation of chromatin structure in memory formation,” Current Opinion in Neurobiology, vol. 19, no. 3, pp. 336–342, 2009.
- L. Rensing, M. Koch, and A. Becker, “A comparative approach to the principal mechanisms of different memory systems,” Naturwissenschaften, vol. 96, no. 12, pp. 1373–1384, 2009.
- C. M. Sweeney-Reed, P. M. Riddell, J. A. Ellis, J. E. Freeman, and S. J. Nasuto, “Neural Correlates of true and false memory in mild cognitive impairment,” PLoS ONE, vol. 7, no. 10, Article ID e48357, 2012.
- B. Straube, “An overview of the neuro-cognitive processes involved in the encoding, consolidation, and retrieval of true and false memories,” Behavioral and Brain Functions, vol. 8, no. 35, 2012.
- H. J. Markowitsch and A. Staniloiu, “The impairment of recollection in functional amnesic states,” Cortex, 2012.
- R. Langnickel and H. J. Markowitsch, “Das unbewusste freuds und die neurowissenschaften,” in Sigmund Freud Heute. Der Vater der Psychoanalyse im Blick der Wissenschaft und der Psychotherapeutischen Schulen, A. Leitner and H. G. Petzold, Eds., pp. 149–173, Krammer, Vienna, Austria, 2010.
- R. Semon, Die Mneme als Erhaltendes Prinzip im Wechsel des organischen Geschehens, Wilhelm Engelmann, Leipzig, Germany, 1904.
- A. Staniloiu and H. J. Markowitsch, “Towards solving the riddle of forgetting in functional amnesia: recent advances and current opinions,” Frontiers in Psychology, vol. 3, article 403, pp. 1–23, 2012.
- S. M. Daselaar, S. E. Prince, N. A. Dennis, S. M. Hayes, H. Kim, and R. Cabeza, “Posterior midline and ventral parietal activity is associated with retrieval success and encoding failure,” Human Neuroscienc, vol. 3, pp. 1–10, 2009.
- D. M. Thomson and E. Tulving, “Encoding specificity and retrieval processes in episodic memory,” Psychological Review, vol. 80, no. 5, pp. 352–373, 1973.
- H. Weingartner, W. Adefris, J. E. Eich, and D. L. Murphy, “Encoding-imagery specificity in alcohol state-dependent learning,” Journal of Experimental Psychology, vol. 2, no. 1, pp. 83–87, 1976.
- S. Freud, “On covered memories,” Monatsschrift für Psychiatrie und Neurologie, vol. 2, pp. 215–230, 1899.
- S. Freud, “On the psychic mechanism of forgetfulness,” Monatsschrift für Psychiatrie und Neurologie, vol. 4-5, pp. 436–443, 1901.
- S. Freud, “On the psychopathology of daily life (forgetting, slips of the tongue, mistakes). Together with remarks on the root of superstititon,” Monatsschrift für Psychiatrie und Neurologie, vol. 10, pp. 1–32, 1901.
- S. Kühnel, F. G. Woermann, M. Mertens, and H. J. Markowitsch, “Involvement of the orbitofrontal cortex during correct and false recognitions of visual stimuli. Implications for eyewitness decisions on an fMRI study using a film paradigm,” Brain Imaging and Behavior, vol. 2, no. 3, pp. 163–176, 2008.
- M. Marini, S. Agosta, G. Mazzoni, G. Dalla Barba, and G. Sartori, “True and false DRM memories: differences detected with an implicit task,” Frontiers in Psychology, vol. 3, article 310, pp. 1–7, 2012.
- R. Cabeza, S. M. Rao, A. D. Wagner, A. R. Mayer, and D. L. Schacter, “Can medial temporal lobe regions distinguish true from false? An event-related functional MRI study of veridical and illusory recognition memory,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 8, pp. 4805–4810, 2001.
- N. A. Dennis, C. R. Bowman, and S. N. Vandekar, “True and phantom recollection: an fMRI investigation of similar and distinct neural correlates and connectivity,” Neuroimage, vol. 59, pp. 2982–2993, 2012.
- R. J. Garoff-Eaton, E. A. Kensinger, and D. L. Schacter, “The neural correlates of conceptual and perceptual false recognition,” Learning and Memory, vol. 14, no. 10, pp. 684–692, 2007.
- H. Kim and R. Cabeza, “Trusting our memories: dissociating the neural correlates of confidence in veridical versus illusory memories,” Journal of Neuroscience, vol. 27, no. 45, pp. 12190–12197, 2007.
- Y. Okado and C. Stark, “Neural processing associated with true and false memory retrieval,” Cognitive, Affective and Behavioral Neuroscience, vol. 3, no. 4, pp. 323–334, 2003.
- U.-M. Risius, A. Staniloiu, M. Piefke, et al., “Retrieval, monitoring and control processes: a 7 Tesla fMRI approach to memory accuracy,” Frontiers in Human Neuroscience, vol. 7, no. 24, 2013.
- G. Miller, “Neuroscience: brain scans of pain raise questions for the law,” Science, vol. 323, no. 5911, p. 195, 2009.
- S. Chen and X. Li, “Functional magnetic resonance imaging for imaging neural activity in the human brain: the annual progress,” Computational and Mathematical Methods in Medicine, vol. 2012, Article ID 613465, 9 pages, 2012.
- H. J. Markowitsch and R. Merkel, “The brain stands trial,” Max-Planck Research, vol. 3, no. 11, pp. 12–17, 2011.
- H. J. Markowitsch, “Neuroscience and crime,” Neurocase, vol. 14, no. 1, pp. 1–6, 2008.
- H. J. Markowitsch and S. Staniloiu, “Neuroscience and the law,” Cortex, vol. 47, pp. 1248–1251, 2011.
- N. Werner, S. Kühnel, A. Ortega, and H. J. Markowitsch, “Drei wege zur falschaussage: lügen, simulation und falsche erinnerungen,” in Menschenwürde und Gehirnintervention, J. C. Joerden, E. Hilgendorf, F. Thiele, et al., Eds., pp. 451–470, Nomos, Baden-Baden,German, 2012.
- J. J. Walczyk, F. P. Igou, A. P. Dixon, and T. Tcholakian, “Advancing lie detection by including cognitive load on liars: a review of relevant theories and techniques guided by lessons form polygraph-based approaches,” Frontiers in Psychology, vol. 4, pp. 1–13, 2013.
- I. Pavlidis, N. L. Eberhardt, and J. A. Levine, “Seeing through the face of deception,” Nature, vol. 415, no. 6867, p. 35, 2002.
- H. J. Markowitsch, A. Thiel, M. Reinkemeier, J. Kessler, A. Koyuncu, and W.-D. Heiss, “Right amygdalar and temporofrontal activation during autobiographic, but not during fictitious memory retrieval,” Behavioural Neurology, vol. 12, no. 4, pp. 181–190, 2000.
- G. R. Fink, H. J. Markowitsch, M. Reinkemeier, T. Bruckbauer, J. Kassler, and W.-D. Heiss, “Cerebral representation of one's own past: neural networks involved in autobiographical memory,” Journal of Neuroscience, vol. 16, no. 13, pp. 4275–4282, 1996.
- H. J. Markowitsch, G. R. Fink, A. Thöne, J. Kessler, and W. D. Heiss, “A PET study of persistent psychogenic amnesia covering the whole life span,” Cognitive Neuropsychiatry, vol. 2, no. 2, pp. 135–158, 1997.
- N. Abe, M. Suzuki, E. Mori, M. Itoh, and T. Fujii, “Deceiving others: distinct neural responses of the prefrontal cortex and amygdala in simple fabrication and deception with social interactions,” Journal of Cognitive Neuroscience, vol. 19, no. 2, pp. 287–295, 2007.
- N. Abe, M. Suzuki, T. Tsukiura et al., “Dissociable roles of prefrontal and anterior cingulate cortices in deception,” Cerebral Cortex, vol. 16, no. 2, pp. 192–199, 2006.
- F. A. Kozel, T. M. Padgett, and M. S. George, “A replication study of the neural correlates of deception,” Behavioral Neuroscience, vol. 118, no. 4, pp. 852–856, 2004.
- F. A. Kozel, K. A. Johnson, Q. Mu, E. L. Grenesko, S. J. Laken, and M. S. George, “Detecting deception using functional magnetic resonance imaging,” Biological Psychiatry, vol. 58, no. 8, pp. 605–613, 2005.
- D. D. Langleben, “Detection of deception with fMRI: are we there yet?” Legal and Criminological Psychology, vol. 13, no. 1, pp. 1–9, 2008.
- D. D. Langleben, J. W. Loughead, W. B. Bilker et al., “Telling truth from lie in individual subjects with fast event-related fMRI,” Human Brain Mapping, vol. 26, no. 4, pp. 262–272, 2005.
- T. M. C. Lee, R. K. C. Au, H.-L. Liu, K. H. Ting, C.-M. Huang, and C. C. H. Chan, “Are errors differentiable from deceptive responses when feigning memory impairment? An fMRI study,” Brain and Cognition, vol. 69, no. 2, pp. 406–412, 2009.
- J. N. Browndyke, J. Paskavitz, L. H. Sweet et al., “Neuroanatomical correlates of malingered memory impairment: event-related fMRI of deception on a recognition memory task,” Brain Injury, vol. 22, no. 6, pp. 481–489, 2008.
- S. A. Spence, M. D. Hunter, T. F. D. Farrow et al., “A cognitive neurobiological account of deception: evidence from functional neuroimaging,” Philosophical Transactions of the Royal Society B, vol. 359, no. 1451, pp. 1755–1762, 2004.
- F. A. Kozel and M. H. Trivedi, “Developing a neuropsychiatric functional brain imaging test,” Neurocase, vol. 14, no. 1, pp. 54–58, 2008.
- J. G. Hakun, D. Seelig, K. Ruparel et al., “fMRI investigation of the cognitive structure of the concealed information test,” Neurocase, vol. 14, no. 1, pp. 59–67, 2008.
- S. A. Spence and C. J. Kaylor-Hughes, “Looking for truth and finding lies: the prospects for a nascent neuroimaging of deception,” Neurocase, vol. 14, no. 1, pp. 68–81, 2008.
- M. Bles and J. D. Haynes, “Detecting concealed information using brain-imaging technology,” Neurocase, vol. 14, no. 1, pp. 82–92, 2008.
- C. Davatzikos, K. Ruparel, Y. Fan et al., “Classifying spatial patterns of brain activity with machine learning methods: application to lie detection,” NeuroImage, vol. 28, no. 3, pp. 663–668, 2005.
- D. D. Langleben, L. Schroeder, J. A. Maldjian et al., “Brain activity during simulated deception: an event-related functional magnetic resonance study,” NeuroImage, vol. 15, no. 3, pp. 727–732, 2002.
- P. R. Wolpe, K. R. Foster, and D. D. Langleben, “Emerging neurotechnologies for lie-detection: promises and perils,” American Journal of Bioethics, vol. 5, no. 2, pp. 39–49, 2005.
- K. E. Sip, A. Roepstorff, W. McGregor, and C. D. Frith, “Detecting deception: the scope and limits,” Trends in Cognitive Sciences, vol. 12, no. 2, pp. 48–53, 2008.
- F. B. Mohamed, S. H. Faro, N. J. Gordon, S. M. Platek, H. Ahmad, and J. M. Williams, “Brain mapping of deception and truth telling about an ecologically valid situation: functional MR imaging and polygraph investigation—initial experience,” Radiology, vol. 238, no. 2, pp. 679–688, 2006.
- S. Bhatt, J. Mbwana, A. Adeyemo, A. Sawyer, A. Hailu, and J. VanMeter, “Lying about facial recognition: an fMRI study,” Brain and Cognition, vol. 69, no. 2, pp. 382–390, 2009.
- T. M. C. Lee, R. K. C. Au, H. L. Liu, K. H. Ting, C.-M. Huang, and C. C. H. Chan, “Are errors differentiable from deceptive responses when feigning memory impairment? An fMRI study,” Brain and Cognition, vol. 69, no. 2, pp. 406–412, 2009.
- H. Pearson, “Lure of lie detectors spokes ethicists,” Nature, vol. 441, no. 7096, pp. 918–919, 2006.
- L. A. Farwell and S. S. Smith, “Using brain MERMER testing to detect knowledge despite efforts to conceal,” Journal of Forensic Sciences, vol. 46, no. 1, pp. 135–143, 2001.
- A. Vrij, P. A. Granhag, S. Mann, and S. Leal, “Outsmarting the liars: toward a cognitive lie detection approach,” Current Directions in Psychological Science, vol. 20, no. 1, pp. 28–32, 2011.
- G. Teichner and M. T. Wagner, “The Test of Memory Malingering (TOMM): normative data from cognitively intact, cognitively impaired, and elderly patients with dementia,” Archives of Clinical Neuropsychology, vol. 19, no. 3, pp. 455–464, 2004.
- T. N. Tombaugh, Test of Memory Malingering (TOMM), Multi Health Systems, New York, NY, USA, 1996.
- M. F. Greiffenstein, K. W. Greve, K. J. Bianchini, and W. J. Baker, “Test of Memory Malingering and Word Memory Test: a new comparison of failure concordance rates,” Archives of Clinical Neuropsychology, vol. 23, no. 7-8, pp. 801–807, 2008.
- P. Green, Word Memory Test for Windows: Test Manual, Green's Publishing, Edmonton, Canada, 2003.
- P. Green, L. Flaro, and J. Courtney, “Examining false positives on the Word Memory Test in adults with mild traumatic brain injury,” Brain Injury, vol. 23, no. 9, pp. 741–750, 2009.
- S. Schagen, B. Schmand, S. de Sterke, and J. Lindeboom, “Amsterdam short-term memory test: a new procedure for the detection of feigned memory deficits,” Journal of Clinical and Experimental Neuropsychology, vol. 19, no. 1, pp. 43–51, 1997.
- B. Schmand and J. Lindeboom, “Amsterdam Short-Term Memory Test,” Leiden, The Netherlands, https://www.pits-online.nl/AKGT.html, 2012.
- M. Martins and I. P. Martins, “Memory malingering: evaluating WMT criteria,” Applied Neuropsychology, vol. 17, no. 3, pp. 177–182, 2010.
- B. Bolan, J. K. Foster, B. Schmand, and S. Bolan, “A comparison of three tests to detect feigned amnesia: the effects of feedback and the measurement of response latency,” Journal of Clinical and Experimental Neuropsychology, vol. 24, no. 2, pp. 154–167, 2002.
- A. Ortega, E.-J. Wagenmakers, M. D. Lee, H. J. Markowitsch, and M. Piefke, “A Bayesian latent group analysis for detecting poor effort in the assessment of malingering,” Archives of Clinical Neuropsychology, vol. 27, pp. 453–465, 2012.
- E. D. Bigler, “Symptom validity testing, effort, and neuropsychological assessment,” Journal of the International Neuropsychological Society, vol. 18, pp. 632–642, 2012.
- K. E. Sip, D. Carmel, J. L. Marchant, et al., “When Pinocchio’s nose does not grow: belief regarding lie-detectability modulates production of deception,” Frontiers in Human Neuroscience, vol. 7, article 16, pp. 1–11, 2013.
- T. Ribot, Diseases of Memory, D. Appleton, New York, NY, USA, 1882.
- N. Butters, “Alcoholic Korsakoff's syndrome: some unresolved issues concerning etiology, neuropathology, and cognitive deficits,” Journal of Clinical Neuropsychology, vol. 7, no. 2, pp. 181–210, 1985.
- M. R. Rosenzweig, E. L. Bennett, P. J. Colombo, D. W. Lee, and P. A. Serrano, “Short-term, intermediate-term, and long-term memories,” Behavioural Brain Research, vol. 57, no. 2, pp. 193–198, 1993.
- F. I. M. Craik and R. S. Lockhart, “Levels of processing: a framework for memory research,” Journal of Verbal Learning and Verbal Behavior, vol. 11, no. 6, pp. 671–684, 1972.
- P. Calabrese, H. J. Markowitsch, H. F. Durwen et al., “Right temporofrontal cortex as critical locus for the ecphory of old episodic memories,” Journal of Neurology Neurosurgery and Psychiatry, vol. 61, no. 3, pp. 304–310, 1996.
- N. E. A. Kroll, H. J. Markowitsch, R. T. Knight, and D. Yves von Cramon, “Retrieval of old memories: the temporofrontal hypothesis,” Brain, vol. 120, no. 8, pp. 1377–1399, 1997.
- K. S. LaBar and R. Cabeza, “Cognitive neuroscience of emotional memory,” Nature Reviews Neuroscience, vol. 7, no. 1, pp. 54–64, 2006.
- H. J. Markowitsch, P. Calabrese, H. Neufeld, W. Gehlen, and H. F. Durwen, “Retrograde amnesia for world knowledge and preserved memory for autobiographic events. A case report,” Cortex, vol. 35, no. 2, pp. 243–252, 1999.
- H. J. Markowitsch, “The mnestic block syndrome: environmentally induced amnesia,” Neurology Psychiatry and Brain Research, vol. 6, no. 2, pp. 73–80, 1998.
- H. J. Markowitsch, J. Kessler, M. O. Russ, L. Frölich, B. Schneider, and K. Maurer, “Mnestic block syndrome,” Cortex, vol. 35, no. 2, pp. 219–230, 1999.
- H. J. Markowitsch, “Functional amnesia: the mnestic block syndrome,” Revue de Neuropsychologie, vol. 10, no. 1, pp. 175–198, 2000.
- H. J. Markowitsch, J. Kessler, G. Weber-Luxenburger, C. van der Ven, M. Albers, and W. D. Heiss, “Neuroimaging and behavioral correlates of recovery from mnestic block syndrome and other cognitive deteriorations,” Neuropsychiatry, Neuropsychology and Behavioral Neurology, vol. 13, no. 1, pp. 60–66, 2000.
- H. J. Markowitsch, “Functional retrograde amnesia—mnestic block syndrome,” Cortex, vol. 38, no. 4, pp. 651–654, 2002.
- M. Brand and H. J. Markowitsch, “Environmental influences on autobiographical memory: the mnestic block syndrome,” in Memory, Aging, and Brain, L. Bäckman and L. Nyberg, Eds., pp. 229–264, Psychology Press, New York, NY, USA, 2010.
- A. D. Baddeley, “The episodic buffer: a new component of working memory?” Trends in Cognitive Sciences, vol. 4, no. 11, pp. 417–423, 2000.
- A. D. Baddeley, Working Memory, Thought and Action, Oxford University Press, Oxford, UK, 2007.
- A. D. Baddeley, R. Allen, and F. Vargha-Khadem, “Is the hippocampus necessary for visual and verbal binding in working memory?” Neuropsychologia, vol. 48, no. 4, pp. 1089–1095, 2010.
- E. Tulving, “Organization of memory: quo vadis?” in The Cognitive Neurosciences, M. S. Gazzaniga, Ed., pp. 839–847, MIT Press, Cambridge, Mass, USA, 1995.
- J. R. Hodges, “Semantic memory and frontal executive function during transient global amnesia,” Journal of Neurology Neurosurgery and Psychiatry, vol. 57, no. 5, pp. 605–608, 1994.
- S. Oddo, S. Lux, P. H. Weiss et al., “Specific role of medial prefrontal cortex in retrieving recent autobiographical memories: an fMRI study of young female subjects,” Cortex, vol. 46, no. 1, pp. 29–39, 2010.
- L. R. Squire, B. Knowlton, and G. Musen, “The structure and organization of memory,” Annual Review of Psychology, vol. 44, no. 1, pp. 453–495, 1993.
- E. Tulving and H. J. Markowitsch, “Episodic and declarative memory: role of the hippocampus,” Hippocampus, vol. 8, pp. 198–204, 1998.
- H. J. Markowitsch, Intellectual Functions of the Brain. An Historical Perspective, Hogrefe & Huber, Toronto, Canada, 1992.
- H. J. Markowitsch, “Zur historie der neurowissenschaften,” in Kognitive Aspekte in Neurologie und Psychiatrie, P. Calabrese and H. J. Markowitsch, Eds., Hippocampus, Bad Honnef, German, 2013.
- E. Clarke and K. Dewhurst, An Illustrated History of Brain Function, Sanford, New York, NY, USA, 1972.
- A. Roy, “A theory of the brain: localist representation is used widely in the brain,” Frontiers in Psychology, vol. 3, article 551, pp. 1–4, 2012.
- R. Quian Quiroga, “Concept cells: the building blocks of declarative memory functions,” Nature Reviews Neuroscience, vol. 13, pp. 587–597, 2012.
- A. R. Damasio and D. Tranel, “Nouns and verbs are retrieved with differently distributed neural systems,” Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 11, pp. 4957–4960, 1993.
- H. J. Markowitsch, “Hypotheses on mnemonic information processing by the brain,” International Journal of Neuroscience, vol. 27, no. 3-4, pp. 191–227, 1985.
- H. J. Markowitsch, “Can amnesia be caused by damage of a single brain structure?” Cortex, vol. 20, no. 1, pp. 27–45, 1984.
- H. J. Markowitsch, “Individual differences in memory performance and the brain,” in Information Processing by the Brain, H. J. Markowitsch, Ed., pp. 125–148, H. Huber, Toronto, Canada, 1988.
- H. J. Markowitsch, “Long term memory processing in the human brain: on the influence of individual variations,” in Systems with Learning and Memory Abilities, J. Delacour and J. C. S. Levy, Eds., pp. 153–176, North-Holland, Amsterdam, The Netherlands, 1988.
- W. B. Scoville, “The limbic lobe in man,” Journal of Neurosurgery, vol. 11, no. 1, pp. 64–66, 1954.
- H. J. Markowitsch, “Der Fall H.M. im Dienste der Hirnforschung,” Naturwissenschaftliche Rundschau, vol. 38, pp. 410–416, 1985.
- H. J. Markowitsch, “Diencephalic amnesia: a reorientation towards tracts?” Brain Research Reviews, vol. 13, no. 4, pp. 351–370, 1988.
- H. J. Markowitsch, “Diencephalic amnesia,” in Trastornos de la Memoria, D. Barcia Salorio, Ed., pp. 269–336, Editorial MCR, Barcelona, Spain, 1992.
- S. S. Korsakoff, “Medico-psychological study on a form of memory disease,” Revue Philosophique, vol. 5, pp. 501–530, 1889.
- S. S. Korsakoff, “A psychic disturbance combined with multiple neuritis (psychosis polyneuritica seu cerebropathia psychia toxaemica),” Allgemeine Zeitschrift für Psychiatrie, vol. 46, pp. 475–485, 1890.
- S. S. Korsakow, “Ueber eine besondere Form psychischer Störung, combinirt mit multipler Neuritis,” Archiv für Psychiatrie und Nervenkrankheiten, vol. 21, no. 3, pp. 669–704, 1890.
- S. S. Korsakow, “Delusions of memory (pseudoreminiscences) in polyneuritic psychosis,” Allgemeine Zeitschrift für Psychiatrie, vol. 47, pp. 390–410, 1891.
- S. S. Korsakow and W. Serbski, “Ein Fall von polyneuritischer Psychose mit Autopsie,” Archiv für Psychiatrie und Nervenkrankheiten, vol. 23, no. 1, pp. 112–134, 1892.
- K. Bonhoeffer, Acute Mental Illnesses of Chronic Drinkers, Fischer, Jena, German, 1901.
- K. Bonhoeffer, “he Korsakoff symptom complex in its relation to different forms of illnesses,” Allgemeine Zeitschrift für Psychiatrie und Psychisch-Gerichtliche Medicin, vol. 61, pp. 744–752, 1904.
- E. Gamper, “On the question of polioencephalitis haemorrhagica of chronic alcoholics. Anatomical results in the chronic Korsakoff state and their relations to the clinical picture,” Deutsche Zeitschrift für Nervenheilkunde, vol. 102, pp. 352–359, 1928.
- W. V. Bechterew, “Demonstration eines Gehirnes mit Zerstörung der vorderen und inneren Theile der Hirnrinde beider Schläfenlappen,” Neurologisches Zentralblatt, vol. 19, pp. 990–991, 1900.
- W. B. Scoville and B. Milner, “Loss of recent memory after bilateral hippocampal lesions,” Journal of Neurology, Neurosurgery, and Psychiatry, vol. 20, no. 1, pp. 11–21, 1957.
- S. Corkin, “What's new with the amnesic patient H.M.?” Nature Reviews Neuroscience, vol. 3, no. 2, pp. 153–160, 2002.
- L. R. Squire, “The legacy of patient H.M. for neuroscience,” Neuron, vol. 61, no. 1, pp. 6–9, 2009.
- E. A. Maguire, F. Vargha-Khadem, and D. Hassabis, “Imagining fictitious and future experiences: evidence from developmental amnesia,” Neuropsychologia, vol. 48, no. 11, pp. 3187–3192, 2010.
- E. B. Isaacs, F. Vargha-Khadem, K. E. Watkins, A. Lucas, M. Mishkin, and D. G. Gadian, “Developmental amnesia and its relationship to degree of hippocampal atrophy,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 22, pp. 13060–13063, 2003.
- F. Vargha-Khadem, D. G. Gadian, K. E. Watkins, A. Connelly, W. Van Paesschen, and M. Mishkin, “Differential effects of early hippocampal pathology on episodic and semantic memory,” Science, vol. 277, no. 5324, pp. 376–380, 1997.
- F. Vargha-Khadem, C. H. Salmond, K. E. Watkins, K. J. Friston, D. G. Gadian, and M. Mishkin, “Developmental amnesia: effect of age at injury,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 17, pp. 10055–10060, 2003.
- A. Staniloiu, F. G. Woermann, S. Borsutzky, and H. J. Markowitsch, “Social cognition in a case of amnesia with neurodevelopmental mechanisms,” Frontiers in Behavioral Neuroscience. In press.
- A. Gilboa, G. Winocur, R. S. Rosenbaum et al., “Hippocampal contributions to recollection in retrograde and anterograde amnesia,” Hippocampus, vol. 16, no. 11, pp. 966–980, 2006.
- D. Hassabis, D. Kumaran, S. D. Vann, and E. A. Maguire, “Patients with hippocampal amnesia cannot imagine new experiences,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 5, pp. 1726–1731, 2007.
- J. S. Holdstock, D. M. Parslow, R. G. Morris et al., “Two case studies illustrating how relatively selective hippocampal lesions in humans can have quite different effects on memory,” Hippocampus, vol. 18, no. 7, pp. 679–691, 2008.
- S. N. Moses, M. L. Ostreicher, R. S. Rosenbaum, and J. D. Ryan, “Successful transverse patterning in amnesia using semantic knowledge,” Hippocampus, vol. 18, no. 2, pp. 121–124, 2008.
- A. Gomez, S. Rousset, and A. Charnallet, “Spatial deficits in an amnesic patient with hippocampal damage: questioning the multiple trace theory,” Hippocampus, vol. 22, no. 6, pp. 1313–1324, 2012.
- K. Woollett, J. Glensman, and E. A. Maguire, “Non-spatial expertise and hippocampal gray matter volume in humans,” Hippocampus, vol. 18, no. 10, pp. 981–984, 2008.
- C. M. Bird, C. Capponi, J. A. King, C. F. Doeller, and N. Burgess, “Establishing the boundaries: the hippocampal contribution to imagining scenes,” Journal of Neuroscience, vol. 30, no. 35, pp. 11688–11695, 2010.
- H. M. Bonnici, M. J. Chadwick, A. Lutti, D. Hassabis, N. Weiskopf, and E. A. Maguire, “Detecting representations of recent and remote autobiographical memories in vmPFC and hippocampus,” Journal of Neuroscience, vol. 32, no. 47, pp. 15982–16991, 2012.
- M. Rose, H. Haider, N. Salari, and C. Büchel, “Functional dissociation of hippocampal mechanism during implicit learning based on the domain of associations,” Journal of Neuroscience, vol. 31, no. 39, pp. 13739–13745, 2011.
- D. R. Addis and D. L. Schacter, “The hippocampus and imagining the future: where do we stand?” Frontiers in Human Neuroscience, vol. 5, article 173, pp. 1–15, 2012.
- S. Booshardt, N. Degonda, C. F. Schmidt et al., “One month of human memory consolidation enhances retrieval-related hippocampal activity,” Hippocampus, vol. 15, no. 8, pp. 1026–1040, 2005.
- B. C. Dickerson, S. L. Miller, D. N. Greve et al., “Prefrontal-hippocampal-fusiform activity during encoding predicts intraindividual differences in free recall ability: an event-related functional-anatomic MRI study,” Hippocampus, vol. 17, no. 11, pp. 1060–1070, 2007.
- R. S. Ross, T. I. Brown, and C. E. Stern, “The retrieval of learned sequences engages the hippocampus: evidence from fMRI,” Hippocampus, vol. 19, no. 9, pp. 790–799, 2009.
- C. N. Smith, J. T. Wixted, and L. R. Squire, “The Hippocampus supports both recollection and familiarity when memories are strong,” Journal of Neuroscience, vol. 31, no. 44, pp. 15693–15702, 2011.
- B. Suchan, A. E. Gayk, G. Schmid, O. Köster, and I. Daum, “Hippocampal involvement in recollection but not familiarity across time: a prospective study,” Hippocampus, vol. 18, no. 1, pp. 92–98, 2008.
- J. A. Weiler, B. Suchan, and I. Daum, “Foreseeing the future: occurrence probability of imagined future events modulates hippocampal activation,” Hippocampus, vol. 20, no. 6, pp. 685–690, 2010.
- I. V. Viskontas, V. A. Carr, S. A. Engel, and B. J. Knowlton, “The neural correlates of recollection: hippocampal activation declines as episodic memory fades,” Hippocampus, vol. 19, no. 3, pp. 265–272, 2009.
- K. Henke, “A model for memory systems based on processing modes rather than consciousness,” Nature Reviews Neuroscience, vol. 11, no. 7, pp. 523–532, 2010.
- D. E. Hannula and A. J. Green, “The hippocampus reevaluated in unconscious learning and memory at a tipping point?” Frontiers in Human Neuroscience, vol. 6, article 80, pp. 1–20, 2012.
- R. N. Henson and P. Gagnepain, “Predictive, interactive multiple memory systems,” Hippocampus, vol. 20, no. 11, pp. 1315–1326, 2010.
- M. Rose, H. Haider, N. Salari, and C. Büchel, “Functional dissociation of hippocampal mechanism during implicit learning based on the domain of associations,” Journal of Neuroscience, vol. 31, no. 39, pp. 13739–13745, 2009.
- M. Toepper, H. J. Markowitsch, H. Gebhardt et al., “Hippocampal involvement in working memory encoding of changing locations: an fMRI study,” Brain Research, vol. 1354, pp. 91–99, 2010.
- C. James, S. Morand, S. Bareellona-Lehmann, C. M. Michel, and A. Schnider, “Neural transition from short-term to long-term memory and the medial temporal lobe: a human evoked-potential study,” Hippocampus, vol. 19, no. 4, pp. 371–378, 2009.
- T. Brandt, F. Schautzer, D. A. Hamilton et al., “Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans,” Brain, vol. 128, no. 11, pp. 2732–2741, 2005.
- K. Hüfner, C. Binetti, D. A. Hamilton et al., “Structural and functional plasticity of the hippocampal formation in professional dancers and slackliners,” Hippocampus, vol. 21, no. 8, pp. 855–865, 2011.
- G. Iaria, L. J. Lanyon, C. J. Fox, D. Giaschi, and J. J. S. Barton, “Navigational skills correlate with hippocampal fractional anisotropy in humans,” Hippocampus, vol. 18, no. 4, pp. 335–339, 2008.
- G. Janzen, C. Jansen, and M. Van Turennout, “Memory consolidation of landmarks in good navigators,” Hippocampus, vol. 18, no. 1, pp. 40–47, 2008.
- N. Suthana, A. Ekstrom, S. Moshirvaziri, B. Knowlton, and S. Bookheimer, “Dissociations within human hippocampal subregions during encoding and retrieval of spatial information,” Hippocampus, vol. 21, no. 7, pp. 694–701, 2011.
- K. I. Erickson, M. W. Voss, R. S. Prakash et al., “Exercise training increases size of hippocampus and improves memory,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 7, pp. 3017–3022, 2011.
- K. I. Erickson, R. S. Prakash, M. W. Voss et al., “Aerobic fitness is associated with hippocampal volume in elderly humans,” Hippocampus, vol. 19, no. 10, pp. 1030–1039, 2009.
- J. M. Monti, C. H. Hillmann, and N. J. Cohen, “Aerobic fitness enhances relational memory in preadolescent children: the FITkids randomized control trial,” Hippocampus, vol. 22, pp. 1876–1882, 2012.
- S. Llewellyn, “Such stuff as dreams are made on? Elaborative encoding, the ancient art of memory and the hippocampus,” Behavioral and Brain Sciences. In press.
- H. J. Markowitsch and A. Staniloiu, “The spaces left over between REM sleep, dreaming, hippocampal formation and episodic-autobiographical memory,” Behavioral and Brain Sciences. In press.
- E. R. John, “Switchboard versus statistical theories of learning and memory,” Science, vol. 177, no. 4052, pp. 850–864, 1972.
- I. V. Viskontas, R. Q. Quiroga, and I. Fried, “Human medial temporal lobe neurons respond preferentially to personally relevant images,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 50, pp. 21329–21334, 2009.
- R. Q. Quiroga, L. Reddy, G. Kreiman, C. Koch, and I. Fried, “Invariant visual representation by single neurons in the human brain,” Nature, vol. 435, no. 7045, pp. 1102–1107, 2005.
- R. Q. Quiroga, G. Kreiman, C. Koch, and I. Fried, “Sparse but not “Grandmother-cell” coding in the medial temporal lobe,” Trends in Cognitive Sciences, vol. 12, no. 3, pp. 87–91, 2008.
- G. Kreiman, C. Koch, and I. Fried, “Category-specific visual responses of single neurons in the human medial temporal lobe,” Nature Neuroscience, vol. 3, no. 9, pp. 946–953, 2000.
- H. J. Markowitsch, Intellectual Functions and the Brain. An Historical Perspective, Hogrefe & Huber, Toronto, Canada, 1992.
- K. Brodmann, “Experimental and clinical contribution to the psychopathology of the polyneuritic psychoses,” Journal für Psychologie und Neurologie, vol. 1, pp. 225–246, 1902.
- K. Brodmann, “Experimental and clinical contribution to the psychopathology of the polyneuritic psychoses. B. Experimental part,” Journal für Psychologie und Neurologie, vol. 3, pp. 1–48, 1904.
- H. Bürger, “On the psychology of the amnesic symptom complex,” Archiv für Psychiatrie und Nervenkrankheiten, vol. 81, pp. 348–352, 1927.
- H. Bürger-Prinz and M. Kaila, “Über die Struktur des amnestischen Symptomenkomplexes,” Zeitschrift für die Gesamte Neurologie und Psychiatrie, vol. 124, no. 1, pp. 553–595, 1930.
- J. Dejerine and G. Roussy, “The thalamic syndrome,” Revue Neurologique, vol. 14, pp. 521–532, 1986.
- F. X. Dercum, “The thalamus in the psysiology and pathology of the mind,” A.M.A. Archives of Neurology and Psychiatry, vol. 14, pp. 289–302, 1925.
- W. R. Gowers, “On some symptoms of organic bbain disease,” Brain, vol. 1, no. 1, pp. 48–59, 1878.
- A. Gregor, “Beiträge zur Kenntnis der Gedächtnisstörung bei der Korsakoffschen Psychose,” Monatsschrift für Psychiatrie und Neurologie, vol. 21, pp. 19–46, 1907.
- A. Gregor, “Beiträge zur Psychopathologie des Gedächtnisses,” Monatsschrift für Psychiatrie und Neurologie, vol. 25, pp. 218–255, 1909.
- E. Grünthal, “On the corpus callosum and the Korsakoff symptom complex,” Confinia Neurologica, vol. 2, pp. 64–95, 1939.
- E. Grünthal, “On thalamic dementia,” Monatsschrift für Psychiatrie und Neurologie, vol. 106, pp. 114–128, 1942.
- J. W. Papez, “A proposed mechanism of emotion,” Archives of Neurology and Psychiatry, vol. 38, pp. 725–743, 1937.
- J. P. Aggleton and M. W. Brown, “Episodic memory, amnesia, and the hippocampal-anterior thalamic axis,” Behavioral and Brain Sciences, vol. 22, no. 3, pp. 425–444, 1999.
- H. J. Markowitsch, “Gestalt view of the limbic system and the Papez circuit—another approach to unity and diversity of brain structures and functions,” Behavioral and Brain Sciences, vol. 22, no. 3, pp. 459–460, 1999.
- J. P. Aggleton, J. R. Dumont, and E. C. Warburton, “Unraveling the contributions of the diencephalon to recognition memory: a review,” Learning and Memory, vol. 18, no. 6, pp. 384–400, 2011.
- M. D. Kopelman, A. D. Thomson, I. Guerrini, and E. J. Marshall, “The korsakoff syndrome: clinical aspects, psychology and treatment,” Alcohol and Alcoholism, vol. 44, no. 2, pp. 148–154, 2009.
- M. Peper, U. Seier, D. Krieger, and H. J. Markowitsch, “Impairment of memory and affect in a patient with reversible bilateral thalamic lesions due to internal cerebral vein thrombosis,” Restorative Neurology and Neuroscience, vol. 2, no. 3, pp. 155–162, 1991.
- E. Fujiwara, M. Brand, S. Borsutzky, H. P. Steingass, and H. J. Markowitsch, “Cognitive performance of detoxified alcoholic Korsakoff syndrome patients remains stable over two years,” Journal of Clinical and Experimental Neuropsychology, vol. 30, no. 5, pp. 576–587, 2008.
- H. J. Markowitsch, “The thalamus and memory,” in Fatal Familial Insomnia: Inherited Prion Diseases, Sleep, and the Thalamus, C. Guilleminault, E. Lugaresi, P. Montagnu, and P.-L. Gambetti, Eds., pp. 117–127, Raven Press, New York, NY, USA, 1994.
- L. Cipolotti, M. Husain, J. Crinion et al., “The role of the thalamus in amnesia: a tractography, high-resolution MRI and neuropsychological study,” Neuropsychologia, vol. 46, no. 11, pp. 2745–2758, 2008.
- S. D. Vann, “Re-evaluating the role of the mammillary bodies in memory,” Neuropsychologia, vol. 48, no. 8, pp. 2316–2327, 2010.
- P. Calabrese, M. Haupts, H. J. Markowitsch, and W. Gehlen, “The cognitive-mnestic performance profile of a patient with bilateral asymmetrical thalamic infarction,” International Journal of Neuroscience, vol. 71, no. 1–4, pp. 101–106, 1993.
- P. Calabrese, M. Haupts, H. J. Markowitsch, and W. Gehlen, “Materialspezifische Gedächtnisdefizite nach bilateral symmetrischem Thalamusinfarkt,” in Verhandlungen der Deutschen Gesellschaft für Neurologie, W. Lang, L. Deecke, and H. Hopf, Eds., vol. 9, pp. 454–456, Springer, Berlin, UK, 1995.
- S. Borsutzky, E. Fujiwara, M. Brand, and H. J. Markowitsch, “Confabulations in alcoholic Korsakoff patients,” Neuropsychologia, vol. 46, no. 13, pp. 3133–3143, 2008.
- E. Carrera and J. Bogousslavsky, “The thalamus and behavior: effects of anatomically distinct strokes,” Neurology, vol. 66, no. 12, pp. 1817–1823, 2006.
- F. Perren, S. Clarke, and J. Bogousslavsky, “The syndrome of combined polar and paramedian thalamic infarction,” Archives of Neurology, vol. 62, no. 8, pp. 1212–1216, 2005.
- H. J. Markowitsch, “Diencephalic amnesia,” in Trastornos de la Memoria, D. Barcia Salorio, Ed., pp. 269–336, Editorial MCR, Barcelona, Spain, 1992.
- H. J. Markowitsch, “Diencephalic amnesia: a reorientation towards tracts?” Brain Research Reviews, vol. 13, no. 4, pp. 351–370, 1988.
- P. Calabrese, H. J. Markowitsch, A. G. Harders, M. Scholz, and W. Gehlen, “Fornix damage and memory: a case report,” Cortex, vol. 31, no. 3, pp. 555–564, 1995.
- A. C. Papanicolaou, K. M. Hasan, C. Boake, T. J. Eluvathingal, and L. Kramer, “Disruption of limbic pathways in a case of profound amnesia,” Neurocase, vol. 13, no. 4, pp. 226–228, 2007.
- S. R. Rudebeck, J. Scholz, R. Millington, G. Rohenkohl, H. Johansen-Berg, and A. C. H. Lee, “Fornix microstructure correlates with recollection but not familiarity memory,” Journal of Neuroscience, vol. 29, no. 47, pp. 14987–14992, 2009.
- A. Poreh, G. Winocur, M. Moscovitch et al., “Anterograde and retrograde amnesia in a person with bilateral fornix lesions following removal of a colloid cyst,” Neuropsychologia, vol. 44, no. 12, pp. 2241–2248, 2006.
- J. P. Aggleton, “Understanding retrosplenial amnesia: insights from animal studies,” Neuropsychologia, vol. 48, no. 8, pp. 2328–2338, 2010.
- U. Rutishauser, E. M. Schuman, and A. N. Mamelak, “Activity of human hippocampal and amygdala neurons during retrieval of declarative memories,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 1, pp. 329–334, 2008.
- R. Hurlemann, M. Wagner, B. Hawellek et al., “Amygdala control of emotion-induced forgetting and remembering: evidence from Urbach-Wiethe disease,” Neuropsychologia, vol. 45, no. 5, pp. 877–884, 2007.
- J. S. Feinstein, C. Buzza, R. Hurlemann, et al., “Fear and panic in humans with bilateral amygdala damage,” Nature Neuroscience, vol. 16, no. 3, pp. 270–272, 2013.
- M. Sarter and H. J. Markowitsch, “The amygdala's role in human mnemonic processing,” Cortex, vol. 21, no. 1, pp. 7–24, 1985.
- R. Babinsky, P. Calabrese, H. F. Durwen et al., “The possible contribution of the amygdala to memory,” Behavioural Neurology, vol. 6, no. 3, pp. 167–170, 1993.
- H. J. Markowitsch, P. Calabrese, M. Wurker et al., “The amygdala's contribution to memory. A study on two patients with Urbach-Wiethe disease,” NeuroReport, vol. 5, no. 11, pp. 1349–1352, 1994.
- M. Siebert, H. J. Markowitsch, and P. Bartel, “Amygdala, affect and cognition: evidence from 10 patients with Urbach-Wiethe disease,” Brain, vol. 126, no. 12, pp. 2627–2637, 2003.
- H. J. Markowitsch and A. Staniloiu, “A rapprochement between emotion and cognition: amygdala, emotion and self relevance in episodic-autobiographical memory,” Behavioral and Brain Sciences, vol. 35, pp. 164–166, 2012.
- H. J. Markowitsch and A. Staniloiu, “The contribution of the amygdala for etablishing and maintaining an autonomous self and autobiographical memory,” in Insights Into the Amygdala: Structure, Function and Implications for Disorders, D. Yilmazer-Hanke, Ed., pp. 277–318, Nova Science Publishers, Hauppauge, NY, USA, 2012.
- D. Y. Von Cramon, H. J. Markowitsch, and U. Schuri, “The possible contribution of the septal region to memory,” Neuropsychologia, vol. 31, no. 11, pp. 1159–1180, 1993.
- G. Weniger, H. J. Markowitsch, and E. Irle, “Anterograde and retrograde mnemonic deficits after unilateral damage of neostriatal, ventral striatal, and basal forebrain structures,” Neurocase, vol. 1, pp. 231–238, 1995.
- R. Babinsky, H. J. Markowitsch, and H. Engel, “Letter to the editor,” Neuropsychiatry, Neuropsychology and Behavioral Neurology, vol. 11, no. 2, pp. 106–107, 1998.
- K. E. Livingston and A. Escobar, “Anatomical bias of the limbic system concept. A proposed reorientation,” Archives of Neurology, vol. 24, no. 1, pp. 17–21, 1971.
- R. Nieuwenhuys, V. Voogt, and C. van Huijzen, The Human Central Nervous System, Springer, Berlin, Germany, 4th edition, 2008.
- H. J. Markowitsch, “Korsakoff’s syndrome,” in Encyclopedia of Behavioral Neuroscience, G. F. Koob, M. Le Moal, R. F. Thompson, R. Poldrack, et al., Eds., vol. 2, pp. 131–136, Academic Press, Oxford, UK, 2010.
- B. Milner, S. Corkin, and H. L. Teuber, “Further analysis of the hippocampal amnesic syndrome: 14-year follow-up study of H.M.,” Neuropsychologia, vol. 6, no. 3, pp. 215–234, 1968.
- D. Contreras, A. Destexhe, T. J. Sejnowski, and M. Steriade, “Control of spatiotemporal coherence of a thalamic oscillation by corticothalamic feedback,” Science, vol. 274, no. 5288, pp. 771–774, 1996.
- F. X. Dercum, “The thalamus in the physiology and pathology of the mind. A.M.A.,” Archives of Neurology and Psychiatry, vol. 14, pp. 289–302, 1925.
- R. Adolphs, D. Tranel, H. Damasio, and A. Damasio, “Impared recognition of emotion in facial expressions following bilateral damage to the human amygdala,” Nature, vol. 372, no. 6507, pp. 669–672, 1994.
- R. Adolphs, D. Tranel, H. Damasio, and A. R. Damasio, “Fear and the human amygdala,” Journal of Neuroscience, vol. 15, no. 9, pp. 5879–5891, 1995.
- D. Tranel, G. Gullickson, M. Koch, and R. Adolphs, “Altered experience of emotion following bilateral amygdala damage,” Cognitive Neuropsychiatry, vol. 11, no. 3, pp. 219–232, 2006.
- D. Tranel and H. Damasio, “Intact electrodermal skin conductance responses after bilateral amygdala damage,” Neuropsychologia, vol. 27, no. 4, pp. 381–390, 1989.
- R. Gupta, M. C. Duff, and D. Tranel, “Bilateral amygdala damage impairs the acquisition and use of common ground in social interaction,” Neuropsychology, vol. 25, no. 2, pp. 137–146, 2011.
- D. P. Kennedy and R. Adolphs, “Impaired fixation to eyes following amygdala damage arises from abnormal bottom-up attention,” Neuropsychologia, vol. 48, no. 12, pp. 3392–3398, 2010.
- R. Adolphs, F. Gosselin, T. W. Buchanan, D. Tranel, P. Schyns, and A. R. Damasio, “A mechanism for impaired fear recognition after amygdala damage,” Nature, vol. 433, no. 7021, pp. 68–72, 2005.
- F. K. D. Nahm, D. Tranel, H. Damasio, and A. R. Damasio, “Cross-modal associations and the human amygdala,” Neuropsychologia, vol. 31, no. 8, pp. 727–744, 1993.
- H. B. Thornton, D. Nel, D. Thornton, J. van Honk, G. A. Baker, and D. J. Stein, “The neuropsychiatry and neuropsychology of lipoid proteinosis,” Journal of Neuropsychiatry and Clinical Neurosciences, vol. 20, no. 1, pp. 86–92, 2008.
- Y. Mihov, K. M. Kendrick, B. Becker, et al., “Mirroring fear in the absence of a functional amygdala,” Biological Psychiatry, vol. 73, no. 7, pp. e9–e11, 2012.
- D. Scheele, Y. Mihov, K. M. Kendrick, et al., “Amygdala lesion profoundly alters in altruistic punishment,” Biological Psychiatry, vol. 72, no. 3, pp. e5–e7, 2012.
- B. Becker, Y. Mihov, D. Scheele, et al., “Fear processing and social networking in the absence of a functional amygdala,” Biological Psychiatry, vol. 72, no. 1, pp. 70–77, 2012.
- P. Sah, R. Marek, C. Strobel, and T. W. Bredy, “The amygdala and medial prefrontal cortex: partners in the fear circuit,” Journal of Physiology. In press.
- I. R. Olson, D. McCoy, E. Klobusicky, and L. A. Ross, “Social cognition and the anterior temporal lobes: a review and theoretical framework,” Social, Cognitive and Affective Neuroscience, vol. 8, no. 2, pp. 123–133, 2013.
- T. Agren, J. Engman, A. Frick, et al., “Disruption of reconsolidation erases a fear memory trace in the human amygdala,” Science, vol. 337, no. 6101, pp. 1550–1552, 2012.
- S. Pichon, S. W. Rieger, and P. Vuilleumier, “Persistent affective biases in human amygdala response following implicit priming with negative emotion concepts,” NeuroImage, vol. 62, no. 3, pp. 1610–1321, 2012.
- J. Yang, Z. Cao, X. Xu, and G. Chen, “The amygdala is involved in affective priming effect for fearful faces,” Brain and Cognition, vol. 80, no. 1, pp. 15–22, 2012.
- M. Mayford, S. A. Siegelbaum, E. R. Kandel, et al., “Synapses and memory storage,” Cold Spring Harbor Perspectives in Biology, vol. 4, no. 6, pp. 1–18, 2012.
- H. J. Markowitsch and A. Staniloiu, “A rapprochement between emotion and cognition: amygdala, emotion and self relevance in episodic-autobiographical memory,” Behavioral and Brain Sciences, vol. 35, pp. 164–166, 2012.
- T. Sharot, E. A. Martorella, M. R. Delgado, and E. A. Phelps, “How personal experience modulates the neural circuitry of memories of September 11,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 1, pp. 389–394, 2007.
- H. H. Kornhuber, “Neural control of input into long-term memory: limbic system and amnestic syndrome in man,” in Memory and Transfer of Information, H. P. Zippel, Ed., pp. 1–22, Plenum Press, New York, NY, USA, 1973.
- E. Schaefer, “Das menschliche Gedächtnis als Informationsspeicher,” Elektronische Rundschau, vol. 14, pp. 79–84, 1960.
- M. M. Mesulam, “Large-scale neurocognitive networks and distributed processing for attention, language, and memory,” Annals of Neurology, vol. 28, no. 5, pp. 597–613, 1990.
- M.-M. Mesulam, “Behavioral neuroanatomy: large-scale networks, association cortex, frontal syndromes, the limbic system, and hemispheric specializations,” in Principles of Behavioral and Cognitive Neurology, M.-M. Mesulam, Ed., pp. 1–120, Oxford University Press, New York, NY, USA, 2nd edition, 2000.
- H. J. Markowitsch, G. Weber-Luxemburger, K. Ewald, J. Kessler, and W. D. Heiss, “Patients with heart attacks are not valid models for medial temporal lobe amnesia. A neuropsychological and FDG-PET study with consequences for memory research,” European Journal of Neurology, vol. 4, no. 2, pp. 178–184, 1997.
- H. J. Markowitsch, J. Kessler, U. Schramm, and L. Frolich, “Severe degenerative cortical and cerebellar atrophy and progressive dementia in a young adult,” Neurocase, vol. 6, no. 4, pp. 357–364, 2000.
- A. Caramazza and A. E. Hillis, “Lexical organization of nouns and verbs in the brain,” Nature, vol. 349, no. 6312, pp. 788–790, 1991.
- A. R. Damasio, “Time-locked multiregional retroactivation: a systems-level proposal for the neural substrates of recall and recognition,” Cognition, vol. 33, no. 1-2, pp. 25–62, 1989.
- E. De Renzi, “Memory disorders following focal neocortical damage,” Philosophical transactions of the Royal Society of London B, vol. 298, no. 1089, pp. 73–83, 1982.
- J. Kay and A. Ellis, “A cognitive neuropsychological case study of anomia: implications for psychological models of word retrieval,” Brain, vol. 110, no. 3, pp. 613–629, 1987.
- D. Nikolić, P. Fries, and W. Singer, “Gamma oscillations: precise temporal coordination without a metronome,” Trends in Cognitive Sciences, vol. 17, no. 2, pp. 54–55, 2013.
- V. V. Moca, D. Nikolic, W. Singer, and R. C. Muresan, “Membrane resonance enables stable and robust gamma oscillations,” Cerebral Cortex, 2013.
- P. J. Uhlhaas and W. Singer, “Neuronal dynamics and neuropsychiatric disorders: toward a translational paradigm for dysfunctional large-scale networks,” Neuron, vol. 75, no. 6, pp. 963–980, 1987.
- J. Aru, T. Bachmann, W. Singer, and L. Melloni, “Distilling the neural correlates of consciousness,” Neuroscience and Biobehavioral Reviews, vol. 36, no. 2, pp. 737–746, 2012.
- M. C. Schmid, W. Singer, and P. Fries, “Thalamic coordination of cortical communication,” Neuron, vol. 75, no. 4, pp. 551–552, 2012.
- H. J. Markowitsch, P. Calabrese, J. Liess, M. Haupts, H. F. Durwen, and W. Gehlen, “Retrograde amnesia after traumatic injury of the fronto-temporal cortex,” Journal of Neurology Neurosurgery and Psychiatry, vol. 56, no. 9, pp. 988–992, 1993.
- H. J. Markowitsch and K. Ewald, “Right-hemispheric fronto-temporal injury leading to severe autobiographical retrograde and moderate anterograde episodic amnesia - Implications for the anatomy of memory,” Neurology Psychiatry and Brain Research, vol. 5, no. 2, pp. 71–78, 1997.
- B. Levine, S. E. Black, R. Cabeza et al., “Episodic memory and the self in a case of isolated retrograde amnesia,” Brain, vol. 121, pp. 1951–1973, 1997.
- C. Lebel, L. Walker, A. Leemans, L. Phillips, and C. Beaulieu, “Microstructural maturation of the human brain from childhood to adulthood,” NeuroImage, vol. 40, no. 3, pp. 1044–1055, 2008.
- E. De Renzi, M. Liotti, and P. Nichelli, “Semantic amnesia with preservation of autobiographic memory. A case report,” Cortex, vol. 23, no. 4, pp. 575–597, 1987.
- G. R. Fink, H. J. Markowitsch, M. Reinkemeier, T. Bruckbauer, J. Kassler, and W. D. Heiss, “Cerebral representation of one's own past: neural networks involved in autobiographical memory,” Journal of Neuroscience, vol. 16, no. 13, pp. 4275–4282, 1996.
- H. J. Markowitch, “Retrograde amnesia: similarities between organic and psychogenic forms,” Neurology Psychiatry and Brain Research, vol. 4, no. 1, pp. 1–8, 1996.
- H. J. Markowitsch, “Organic and psychogenic retrograde amnesia: two sides of the same coin?” Neurocase, vol. 2, no. 4, pp. 357–371, 1996.
- A. N. Schore, “Dysregulation of the right brain: a fundamental mechanism of traumatic attachment and the psychopathogenesis of posttraumatic stress disorder,” Australian and New Zealand Journal of Psychiatry, vol. 36, no. 1, pp. 9–30, 2002.
- R. E. Goldsmith, R. E. Cheit, and M. E. Wood, “Evidence of dissociative amnesia in science and literature: culture-bound approaches to trauma in Pope, Poliakoff, Parker, Boynes, and Hudson (2007),” Journal of Trauma and Dissociation, vol. 10, no. 3, pp. 237–253, 2009.
- A. Souques, “Essay about retrograde-anterograde amnesia in hysteria, cerebral trauma and chronic alcoholism,” Revue Medicine, vol. 13, pp. 367–401, 1892.
- P. Janet, “Hysterical amnesia,” Archives de Neurologie, vol. 24, pp. 29–55, 1892.
- P. Janet, The Major Symptoms of Hysteria: Fifteen Lectures Given in the Medical School of Harvard University, Macmillan, New York, NY, USA, 1907.
- J. Bogousslavsky, “Hysteria after Charcot: back to the future,” Frontiers of Neurology and Neuroscience, vol. 29, pp. 137–161, 2011.
- J. M. Charcot, “Sur un cas d'amnesie retro-anterograde,” Revue de Medicine, vol. 12, pp. 81–96, 1892.
- A. H. Bennett, “Case of cerebral tumour-symptoms simulating hysteria,” Brain, vol. 1, no. 1, pp. 114–120, 1878.
- J. Breuer and S. Freud, Studien über Hysterie, Deuticke, Wien, Austria, 1895.
- S. J. Ganser, “Ueber einen eigenartigen hysterischen Dämmerzustand—vortrag, gehalten am 23. October 1897 in der Versammlung der mitteldeutschen Psychiater und Neurologen zu Halle,” Archiv für Psychiatrie und Nervenkrankheiten, vol. 30, no. 2, pp. 633–640, 1898.
- J. Bauer, “Hysterische Erkrankungen bei Kriegsteilnehmern,” Archiv für Psychiatrie und Nervenkrankheiten, vol. 57, no. 1, pp. 139–168, 1916.
- M. D. Kopelman, “Amnesia: organic and psychogenic,” British Journal of Psychiatry, vol. 150, pp. 428–442, 1987.
- N. Reinhold and H. J. Markowitsch, “Retrograde episodic memory and emotion: a perspective from patients with dissociative amnesia,” Neuropsychologia, vol. 47, no. 11, pp. 2197–2206, 2009.
- H. Lundholm, “The riddle of functional amnesia,” Journal of Abnormal and Social Psychology, vol. 26, no. 4, pp. 355–366, 1932.
- E. Fujiwara, M. Brand, L. Kracht et al., “Functional retrograde amnesia: a multiple case study,” Cortex, vol. 44, no. 1, pp. 29–45, 2008.
- M. Kritchevsky, J. Chang, and L. R. Squire, “Functional amnesia: clinical description and neuropsychological profile of 10 cases,” Learning and Memory, vol. 11, no. 2, pp. 213–226, 2004.
- E. Tramoni, S. Aubert-Khalfa, M. Guye, J. P. Ranjeva, O. Felician, and M. Ceccaldi, “Hypo-retrieval and hyper-suppression mechanisms in functional amnesia,” Neuropsychologia, vol. 47, no. 3, pp. 611–624, 2009.
- DSM-IV-TR, Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association, Washington, DC, USA, 4th edition, 2000.
- H. J. Markowitsch, J. Kessler, E. Kalbe, and K. Herholz, “Functional amnesia and memory consolidation: a case of severe and persistent anterograde amnesia with rapid forgetting following whiplash injury,” Neurocase, vol. 5, no. 3, pp. 189–200, 1999.
- C. N. Smith, J. C. Frascino, D. L. Kripke, P. R. McHugh, G. J. Treisman, and L. R. Squire, “Losing memories overnight: a unique form of human amnesia,” Neuropsychologia, vol. 48, no. 10, pp. 2833–2840, 2010.
- A. Staniloiu and H. J. Markowitsch, “Understanding psychogenic amnesia and psychiatric disorders as causes of dementia,” Journal of General Medicine, vol. 22, pp. 41–49, 2010.
- H. J. Markowitsch, P. Calabrese, G. R. Fink et al., “Impaired episodic memory retrieval in a case of probable psychogenic amnesia,” Psychiatry Research, vol. 74, no. 2, pp. 119–126, 1997.
- H. J. Markowitsch, J. Kessler, C. Van der Ven, G. Weber-Luxenburger, M. Albers, and W.-D. Heiss, “Psychic trauma causing grossly reduced brain metabolism and cognitive deterioration,” Neuropsychologia, vol. 36, no. 1, pp. 77–82, 1998.
- H. J. Markowitsch, A. Thiel, J. Kessler, H. M. von Stockhausen, and W.-D. Heiss, “Ecphorizing semi-conscious information via the right temporopolar cortex—a PET study,” Neurocase, vol. 3, no. 6, pp. 445–449, 1997.
- E. Fujiwara, M. Piefke, S. Lux et al., “Brain correlates of functional retrograde amnesia in three patients,” Brain and Cognition, vol. 54, no. 2, pp. 135–136, 2004.
- N. Reinhold and H. J. Markowitsch, “Emotion and consciousness in adolescent psychogenic amnesia,” Journal of Neuropsychology, vol. 1, no. 1, pp. 53–64, 2007.
- N. Reinhold and H. J. Markowitsch, “Retrograde episodic memory and emotion: a perspective from patients with dissociative amnesia,” Neuropsychologia, vol. 47, no. 11, pp. 2197–2206, 2009.
- K. Pommerenke, A. Staniloiu, H. J. Markowitsch, H. Eulitz, R. Gütler, and C. Dettmers, “Ein Fall von retrograder Amnesie nach Resektion eines Medullablastoms—psychogen/funktionell oder organisch?” Neurologie & Rehabilitation, vol. 18, pp. 106–116, 2012.
- M. Brand, C. Eggers, N. Reinhold et al., “Functional brain imaging in 14 patients with dissociative amnesia reveals right inferolateral prefrontal hypometabolism,” Psychiatry Research, vol. 174, no. 1, pp. 32–39, 2009.
- J. Kessler, H. J. Markowitsch, M. Huber, E. Kalbe, G. Weber-Luxenburger, and P. Kock, “Massive and persistent anterograde amnesia in the absence of detectable brain damage: anterograde psychogenic amnesia or gross reduction in sustained effort?” Journal of Clinical and Experimental Neuropsychology, vol. 19, no. 4, pp. 604–614, 1997.
- G. E. Störring, “On the first pure case of a man with complete, isolated loss of memory. (At the same time a contribution to the psychology of emotions, will, and action,” Archiv für die Gesamte Psychologie, vol. 81, pp. 257–384, 1931.
- H. J. Markowitsch and A. Staniloiu, “Gehirn und gewalt: der determinierte täter,” in Verantwortung als Illusion? H. Fink and R. Rosenzweig, Eds., pp. 37–70, Mentis, Paderborn, Germany, 2012.
- C. G. Jung, “A case of hysteric stupor in a prisoner on trial,” Journal für Psychologie und Neurologie, vol. 1, pp. 110–122, 1902.
- J. Raecke, “Ueber epileptische Wanderzustände (Fugues, Poriomanie),” Archiv für Psychiatrie und Nervenkrankheiten, vol. 43, no. 1, pp. 398–423, 1907.
- O. Woltär, “On the state of consciousness during a fugue state,” Jahrbücher für Psychiatrie und Neurologie, vol. 27, pp. 125–143, 1906.
- E. B. Angell, “A case of double consciousness-amnesic type, with fabrication of memory,” Journal of Abnormal Psychology, vol. 1, no. 4, pp. 155–169, 1906.
- M. Azam, “Periodical amnesia; or, double consciousness,” Journal of Nervous and Mental Disease, vol. 3, pp. 584–612, 1876.
- C. L. Dana, “The study of a case of amnesia or ‘double consciousness’,” Psychological Review, vol. 1, no. 6, pp. 570–580, 1894.
- A. Wilson, “A case of double consciousness,” Journal of Mental Science, vol. 49, pp. 640–658, 1903.
- A. Glaus, “On depersonalizatzion, nihilistic delusional ideas, mirror images, Doppelgänger and Golem in the writings of Annette von Droste-Hülshoff,” Monatsschrift für Psychiatrie und Neurologie, vol. 125, pp. 398–416, 1953.
- A. Staniloiu and H. J. Markowitsch, “Dissociation, memory, and trauma narrative,” Journal of Literary Theory, vol. 6, pp. 103–130, 2012.
- A. Gordon, “On ‘double ego’,” American Journal of the Medical Sciences, vol. 131, pp. 480–486, 1906.
- H. J. Markowitsch, “Time, memory and consciousness: a view from the brain,” in Endophysics, Time, Quantum, and the Subjective, R. Buccheri, A. C. Elitzur, M. Saniga, et al., Eds., pp. 131–147, World Scientific, Singapur, 2005.
- S. B. Klein, T. P. German, L. Cosmides, and R. Gabriel, “A theory of autobiographical memory: necessary components and disorders resulting from their loss,” Social Cognition, vol. 22, no. 5, pp. 460–490, 2004.
- S. B. Klein and C. E. Gangi, “The multiplicity of self: neuropsychological evidence and its implications for the self as a construct in psychological research,” Annals of the New York Academy of Sciences, vol. 1191, pp. 1–15, 2010.
- S. B. Klein, “The two selves: the self of conscious experience and its brain,” in Handbook of Self and Identity, M. R. Leary and J. P. Tangney, Eds., Guilford Publications, New York, NY, USA, 2nd edition, 2013.
- S. B. Klein, “Making the case that episodic recollection is attributable to operations occurring at retrieval rather than to content stored in a dedicated subsystem of long-term memory,” Frontiers in Behavorial Neuroscience, vol. 7, article 3, pp. 1–14, 2012.
- C. Lieberwirth and Z. Wang, “The social environment and neurogenesis in the adult mammalian brain,” Frontiers in Human Neuroscience, vol. 6, article 118, pp. 1–19, 2012.
- T. C. Südhof and R. C. Malenka, “Understanding synapses: past, present, and future,” Neuron, vol. 60, no. 3, pp. 469–476, 2008.
- M. S. Wietecha, W. L. Cerny, and L. A. Dipietro, “Mechanisms of vessel regression:toward an understanding of the resolution of angiogenesis,” Current Topics in Microbiology and Immunology, vol. 367, pp. 3–32, 2012.
- J. Sacher, J. Neumann, H. Okon-Singer, S. Gotowiec, and A. Villringer, “Sexual dimorphism in the human brain: evidence from neuroimaging,” Magnetic Resonance Imaging, vol. 31, no. 3, pp. 366–375, 2013.
- K. Amunts, E. Armstrong, A. Malikovic et al., “Gender-specific left-right asymmetries in human visual cortex,” Journal of Neuroscience, vol. 27, no. 6, pp. 1356–1364, 2007.
- L. Cahill, “Why sex matters for neuroscience,” Nature Reviews Neuroscience, vol. 7, no. 6, pp. 477–484, 2006.
- J. M. Cantor, N. Kabani, B. K. Christensen et al., “Cerebral white matter deficiencies in pedophilic men,” Journal of Psychiatric Research, vol. 42, no. 3, pp. 167–183, 2008.
- A. Rodríguez Moreno, A. González-Rueda, A. Banerjee, A. L. Upton, M. T. Craig, and O. Paulsen, “Presynaptic self-depression at developing neocortical synapses,” Neuron, vol. 77, no. 1, pp. 35–42, 2013.
- B. A. Wandell and J. D. Yeatman, “Biological development of reading circuits,” Current Opinion in Neurobiology, vol. 23, no. 2, pp. 261–268, 2013.
- A. N. Voineskos, T. K. Rajji, N. J. Lobaugh, et al., “Age-related decline in white matter tract integrity and cognitive performance: a DTI tractography and structural equation modeling study,” Neurobiology of Aging, vol. 33, pp. 21–34, 2012.
- S. Han, G. Northoff, K. Vogeley, B. E. Wexler, S. Kitayama, and M. E. Varnum, “A cultural neuroscience approach to the biosocial nature of the human brain,” Annual Reviews of Psychology, vol. 64, pp. 335–359, 2013.
- R. D. Fernald, “Social control of the brain,” Annual Reviews of Neuroscience, vol. 35, pp. 133–151, 2012.
- D. P. Kennedy and R. Adolphs, “The social brain in psychiatric and neurological disorders,” Trends in Cognitive Sciences, vol. 16, no. 11, pp. 559–572, 2012.
- R. Adolphs, “The social brain: neural basis of social knowledge,” Annual Review of Psychology, vol. 60, pp. 693–716, 2009.
- D. C. Park and P. Reuter-Lorenz, “The adaptive brain: aging and neurocognitive scaffolding,” Annual Review of Psychology, vol. 60, pp. 173–196, 2009.
- M. Brand and H. J. Markowitsch, “Aging and decision-making: a neurocognitive perspective,” Gerontology, vol. 56, no. 3, pp. 319–324, 2010.
- R. Stewart, “Subjective cognitive impairment,” Current Opinion in Psychiatry, vol. 25, no. 6, pp. 445–450, 2012.
- M. Brand and H. J. Markowitsch, “The principle of bottleneck structures,” in Principles of Learning and Memory, R. H. Kluwe, G. Lüer, and F. Rösler, Eds., pp. 171–184, Birkhäuser, Basel, Switzerland, 2003.
- J. Kessler, H. J. Markowitsch, M. Ghaemi, J. Rudolf, G. H. Weniger, and W.-D. Heiss, “Degenerative prefrontal damage in a young adult: static and dynamic imaging and neuropsychological correlates,” Neurocase, vol. 5, no. 2, pp. 173–179, 1999.
- H. J. Markowitsch and J. Kessler, “Massive impairment in executive functions with partial preservation of other cognitive functions: the case of a young patient with severe degeneration of the prefrontal cortex,” Experimental Brain Research, vol. 133, no. 1, pp. 94–102, 2000.
- K. Blennow, J. Hardy, and H. Zetterberg, “The neuropathology and neurobiology of traumatic brain injury,” Neuron, vol. 76, no. 5, pp. 886–899, 2012.
- M. C. Silveri, B. L. Salvigni, C. Jenner, and P. Colamonico, “Behavior in degenerative dementias: mood disorders, psychotic symptoms and predictive value of neuropsychological deficits,” Archives of Gerontology and Geriatrics, vol. 38, supplement 9, pp. 365–378, 2004.
- H. Förstl, “Neuro-enhancement. BBrain doping,” Nervenarzt, vol. 80, no. 7, pp. 840–846, 2009.
- T. Iuculano and R. Cohen Kadosch, “The mental cost of cognitive enhancement,” Journal of Neuroscience, vol. 33, no. 10, pp. 4482–4486, 2013.
- Y. Dudai, “The restless engram: consolidations never end,” Annual Reviews of Neuroscience, vol. 35, pp. 227–247, 2012.
- N. K. Logothetis, O. Eschenko, Y. Murayama, et al., “Hippocampal-cortical interaction during periods of subcortical silence,” Nature, vol. 491, pp. 547–553, 2012.
- G. Girardeau and M. Zugaro, “Hippocampal ripples and memory consolidation,” Current Opinion in Neurobiology, vol. 21, no. 3, pp. 452–459, 2011.
- N. Axmacher, C. E. Elger, and J. Fell, “Ripples in the medial temporal lobe are relevant for human memory consolidation,” Brain, vol. 131, no. 7, pp. 1806–1817, 2008.
- J. Rissman and A. D. Wagner, “Distributed representations in memory: insights from functional brain imaging,” Annual Reviews of Psychology, vol. 63, pp. 101–128, 2012.
- P. Calabrese and H. J. Markowitsch, “Memory and brain—neurobiological correlates of memory disturbances,” Fortschritte der Neurologie Psychiatrie, vol. 71, no. 4, pp. 211–219, 2003.
- A. M. Owen, “Detecting consciousness: a unique role for neuroimaging,” Annual Reviews of Psychology, vol. 64, pp. 109–133, 2013.
- M. S. Gazzaniga, “Shifting gears: seeking new approaches for mind/brain mechanisms,” Annual Reviews of Psychology, vol. 64, pp. 1–20, 2013.
- M. A. Cohen and D. C. Dennett, “Consciousness cannot be separated from function,” Trends in Cognitive Sciences, vol. 15, no. 8, pp. 358–364, 2011.