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ISRN Oncology
Volume 2012 (2012), Article ID 492578, 8 pages
doi:10.5402/2012/492578
Clinical Study

Detection of PIK3CA Mutations in Breast Cancer Bone Metastases

Manijeh Daneshmand,1 Jennifer E. L. Hanson,1 Mitra Nabavi,2 John F. Hilton,3 Lisa Vandermeer,1 Femina Kanji,1 Susan F. Dent,1,3 Mark Clemons,1,3 and Ian A. J. Lorimer1,3,4

1Centre for Cancer Therapeutics, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, K1H 8L6, Canada
2Department of Pathology, Ottawa Hospital, Ottawa, K1H 8L6, Canada
3Department of Medicine, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada
4Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada

Received 28 May 2012; Accepted 25 June 2012

Academic Editors: G. E. Lind, V. Lorusso, and R. Nahta

Copyright © 2012 Manijeh Daneshmand et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. P. Shah, R. D. Morin, J. Khattra et al., “Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution,” Nature, vol. 461, no. 7265, pp. 809–813, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Yachida, S. Jones, I. Bozic et al., “Distant metastasis occurs late during the genetic evolution of pancreatic cancer,” Nature, vol. 467, no. 7319, pp. 1114–1117, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. B. Karakas, K. E. Bachman, and B. H. Park, “Mutation of the PIK3CA oncogene in human cancers,” British Journal of Cancer, vol. 94, no. 4, pp. 455–459, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Zhao and P. K. Vogt, “Class I PI3K in oncogenic cellular transformation,” Oncogene, vol. 27, no. 41, pp. 5486–5496, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. R. J. Crowder, C. Phommaly, Y. Tao et al., “PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer,” Cancer Research, vol. 69, no. 9, pp. 3955–3962, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. A. G. Bader, S. Kang, and P. K. Vogt, “Cancer-specific mutations in PIK3CA are oncogenic in vivo,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 5, pp. 1475–1479, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. A. G. Bader, S. Kang, L. Zhao, and P. K. Vogt, “Oncogenic PI3K deregulates transcription and translation,” Nature Reviews Cancer, vol. 5, no. 12, pp. 921–929, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. J. D. Jensen, A. V. Laenkholm, A. Knoop et al., “PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer,” Clinical Cancer Research, vol. 17, no. 4, pp. 667–677, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Kalinsky, A. Heguy, U. K. Bhanot, S. Patil, and M. E. Moynahan, “PIK3CA mutations rarely demonstrate genotypic intratumoral heterogeneity and are selected for in breast cancer progression,” Breast Cancer Research and Treatment, vol. 129, pp. 635–643, 2011.
  10. A. M. Gonzalez-Angulo, J. Ferrer-Lozano, K. Stemke-Hale et al., “PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer,” Molecular Cancer Therapeutics, vol. 10, no. 6, pp. 1093–1101, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. J. F. Hilton, E. Amir, S. Hopkins et al., “Acquisition of metastatic tissue from patients with bone metastases from breast cancer,” Breast Cancer Research and Treatment, vol. 129, no. 3, pp. 761–765, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. F. B. Dean, S. Hosono, L. Fang et al., “Comprehensive human genome amplification using multiple displacement amplification,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 8, pp. 5261–5266, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. K. Kalinsky, L. M. Jacks, A. Heguy et al., “PIK3CA mutation associates with improved outcome in breast cancer,” Clinical Cancer Research, vol. 15, no. 16, pp. 5049–5059, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Amir, N. Miller, W. Geddie, O. Freedman, F. Kassam, and C. Simmons, “Prospective study evaluating the impact of tissue confirmation of metastatic disease in patients with breast cancer,” Journal of Clinical Oncology, vol. 30, no. 6, pp. 587–592, 2012.
  15. V. Serra, B. Markman, M. Scaltriti et al., “NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations,” Cancer Research, vol. 68, no. 19, pp. 8022–8030, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. E. Leung, J. E. Kim, G. W. Rewcastle, G. J. Finlay, and B. C. Baguley, “Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifen-resistant breast cancer cells,” Cancer Biology and Therapy, vol. 11, no. 11, pp. 938–946, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. C. G. Sanchez, C. X. Ma, R. J. Crowder et al., “Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer,” Breast Cancer Research, vol. 13, no. 2, article R21, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Chakrabarty, V. Sanchez, M. G. Kuba, C. Rinehart, and C. L. Arteaga, “Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 8, pp. 2718–2723, 2012.