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Volume 2012 (2012), Article ID 691430, 7 pages
Cyclin A2 Protein Overexpression Is Not Caused by Gene Amplification in Colon Cancer
1Quality and Research Department, Ostfold Hospital Trust, Jernbanegaten 11, 2. Et, Postboks 16, 1603 Fredrikstad, Norway
2Institute of Clinical Epidemiology and Molecular Biology (EpiGen), Akershus University Hospital, 1478 Lørenskog, Norway
3Department of Pathology, Oslo University Hospital Rikshospitalet, 0027 Oslo, Norway
4Department of Pathology, Akershus University Hospital, 1478 Lørenskog, Norway
5Institute of Clinical Medicine, University of Oslo, 0316 Oslo, Norway
6Department of Surgery, Akershus University Hospital, 1478 Lørenskog, Norway
7Department of Health Promotion, Akershus University Hospital, 1478 Lørenskog, Norway
8Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, 1432 Ås, Norway
Received 8 June 2012; Accepted 19 July 2012
Academic Editors: C. E. Bacchi and M. Yamakawa
Copyright © 2012 Lise Aagaard Sørby et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- M. Malumbres and M. Barbacid, “Cell cycle, CDKs and cancer: a changing paradigm,” Nature Reviews Cancer, vol. 9, no. 3, pp. 153–166, 2009.
- J. K. Kim and J. A. Diehl, “Nuclear cyclin D1: an oncogenic driver in human cancer,” Journal of Cellular Physiology, vol. 220, no. 2, pp. 292–296, 2009.
- K. E. Knudsen, J. A. Diehl, C. A. Haiman, and E. S. Knudsen, “Cyclin D1: polymorphism, aberrant splicing and cancer risk,” Oncogene, vol. 25, no. 11, pp. 1620–1628, 2006.
- A. Husdal, G. Bukholm, and I. R. K. Bukholm, “The prognostic value and overexpression of cyclin A is correlated with gene amplification of both cyclin A and cyclin E in breast cancer patient,” Cellular Oncology, vol. 28, no. 3, pp. 107–116, 2006.
- I. R. K. Bukholm, G. Bukholm, and J. M. Nesland, “Over-expression of cyclin a is highly associated with early relapse and reduced survival in patients with primary breast carcinomas,” International Journal of Cancer, vol. 93, no. 2, pp. 283–287, 2001.
- R. Königsberg, O. Rögelsperger, W. Jäger et al., “Cell cycle dysregulation influences survival in high risk breast cancer patients,” Cancer Investigation, vol. 26, no. 7, pp. 734–740, 2008.
- R. Michalides, H. van Tinteren, A. Balkenende et al., “Cyclin A is a prognostic indicator in early stage breast cancer with and without tamoxifen treatment,” British Journal of Cancer, vol. 86, no. 3, pp. 402–408, 2002.
- J. J. M. Michels, F. Duigou, J. Marnay et al., “Flow cytometry and quantitative immunohistochemical study of cell cycle regulation proteins in invasive breast carcinoma: prognostic significance,” Cancer, vol. 97, no. 6, pp. 1376–1386, 2003.
- E. Baldini, A. Camerini, A. Sgambato et al., “Cyclin A and E2F1 overexpression correlate with reduced disease-free survival in node-negative breast cancer patients,” Anticancer Research, vol. 26, no. 6B, pp. 4415–4421, 2006.
- L. Li, K. Mu, G. Zhou, L. Lan, G. Auer, and A. Zetterberg, “Genomic instability and proliferative activity as risk factors for distant metastases in breast cancer,” British Journal of Cancer, vol. 99, no. 3, pp. 513–519, 2008.
- J. Bondi, A. Husdal, G. Bukholm, J. M. Nesland, A. Bakka, and I. R. K. Bukholm, “Expression and gene amplification of primary (A, B1, D1, D3, and E) and secondary (C and H) cyclins in colon adenocarcinomas and correlation with patient outcome,” Journal of Clinical Pathology, vol. 58, no. 5, pp. 509–514, 2005.
- J. Q. Li, H. Miki, F. Wu et al., “Cyclin a correlates with carcinogenesis and metastasis, and p27kip1 correlates with lymphatic invasion, in colorectal neoplasms,” Human Pathology, vol. 33, no. 10, pp. 1006–1015, 2002.
- K. Handa, M. Yamakawa, H. Takeda, S. Kimura, and T. Takahashi, “Expression of cell cycle markers in colorectal carcinoma: superiority of cyclin A as an indicator of poor prognosis,” International Journal of Cancer, vol. 84, no. 3, pp. 225–233, 1999.
- A. A. Bahnassy, A. R. N. Zekri, S. El-Houssini et al., “Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients,” BMC Gastroenterology, vol. 4, article 22, 2004.
- C. H. Yam, T. K. Fung, and R. Y. C. Poon, “Cyclin A in cell cycle control and cancer,” Cellular and Molecular Life Sciences, vol. 59, no. 8, pp. 1317–1326, 2002.
- M. F. Buckley, K. J. E. Sweeney, J. A. Hamilton et al., “Expression and amplification of cyclin genes in human breast cancer,” Oncogene, vol. 8, no. 8, pp. 2127–2133, 1993.
- U. Lehmann and H. Kreipe, “Real-time PCR analysis of DNA and RNA extracted from formalin-fixed and paraffin-embedded biopsies,” Methods, vol. 25, no. 4, pp. 409–418, 2001.
- P. Lichter, C. C. Tang, K. Call et al., “High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones,” Science, vol. 247, no. 4938, pp. 64–69, 1990.
- K. J. Livak and T. D. Schmittgen, “Analysis of relative gene expression data using real-time quantitative PCR and the method,” Methods, vol. 25, no. 4, pp. 402–408, 2001.
- P. Platzer, M. B. Upender, K. Wilson et al., “Silence of chromosomal amplifications in colon cancer,” Cancer Research, vol. 62, no. 4, pp. 1134–1138, 2002.
- Z. Herceg and P. Hainaut, “Genetic and epigenetic alterations as biomarkers for cancer detection, diagnosis and prognosis,” Molecular Oncology, vol. 1, no. 1, pp. 26–41, 2007.
- R. Aamodt, K. Jonsdottir, S. N. Andersen, J. Bondi, G. Bukholm, and I. R. K. Bukholm, “Differences in protein expression and gene amplification of cyclins between colon and rectal adenocarcinomas,” Gastroenterology Research and Practice, vol. 2009, Article ID 285830, 9 pages, 2009.
- P. Szepetowski, D. Perucca-Lostanlen, and P. Gaudray, “Mapping genes according to their amplification status in tumor cells: contribution to the map of 11q13,” Genomics, vol. 16, no. 3, pp. 745–750, 1993.
- R. M. Seth, A. M. Burger, and H. J. Kahn, “Analysis of the HER2/neu gene amplification in microdissected breast cancer tumour samples,” Anticancer Research, vol. 26, no. 2A, pp. 927–931, 2006.
- X. Shi, J. Kleeff, Z. W. Zhu et al., “Gene-expression analysis of single cells-nested polymerase chain reaction after laser microdissection,” World Journal of Gastroenterology, vol. 9, no. 6, pp. 1337–1341, 2003.
- V. Bazan, G. La Rocca, S. Corsale et al., “Laser pressure catapulting (LPC): optimization LPC-system and genotyping of colorectal carcinomas,” Journal of Cellular Physiology, vol. 202, no. 2, pp. 503–509, 2005.