Research Article
Age Variance in the Survival of United States Pediatric Leukemia Patients (1973–2006)
Table 2
Mortality associated with age at diagnosis and other factors in pediatric patients with leukemia, 1973–2006.
| Covariates | Hazard ratio (HR) | 99% CI | |
| Age at diagnosis (yrs) | | | | <1.0 | 1.00 | ref | ref | 1.0–4.0 | 0.26 | 0.22–0.30 | <0.0001 | 5.0–9.0 | 0.33 | 0.28–0.39 | <0.0001 | 10.0–14.0 | 0.56 | 0.48–0.66 | <0.0001 | 15.0–19.0 | 0.89 | 0.77–1.04 | 0.05 | Sex | | | | Male | 1.00 | ref | ref | Female | 0.86 | 0.80–0.93 | <0.0001 | Race | | | | White | 1.00 | ref | ref | Black | 1.54 | 1.36–1.74 | <0.0001 | Cell type | | | | T-cell | 1.00 | ref | ref | B-cell, B-precursor | 0.49 | 0.41–0.59 | <0.0001 | Year of diagnosis | | | | 1973–1977 | 1.00 | ref | ref | 1978–1982 | 0.73 | 0.64–0.84 | <0.0001 | 1983–1987 | 0.60 | 0.52–0.69 | <0.0001 | 1988–1992 | 0.42 | 0.36–0.48 | <0.0001 | 1993–1997 | 0.38 | 0.33–0.43 | <0.0001 | 1998–2002 | 0.33 | 0.29–0.37 | <0.0001 | 2003–2006 | 0.29 | 0.25–0.34 | <0.0001 | No. of primaries | | | | 1.0 | 1.00 | ref | ref | ≥2.0 | 1.75 | 1.40–2.20 | <0.0001 | Beam radiation | | | | Yes | 1.00 | ref | ref | No | 0.84 | 0.77–0.92 | <0.0001 |
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Notes and Abbreviations. The significance level was 0.01. CI: confidence interval.
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