Table 2:
Physicochemical parameters of microspheres.
Formulation
Yield (%)
(X ± SD)
Actual drug content (mg)
(X ± SD)
Theoretical drug content (mg)
Drug entrapment efficiency (%)
(X ± SD)
Particle size (
μ
m)
(X ± SD)
Moisture loss (%)
F1
8
5
.
2
±
.
0
9
8
1
7
.
9
8
±
.
1
1
6
66.66
2
6
.
9
7
±
.
1
6
7
3
4
.
5
6
±
.
2
1
3
1.07
F2
8
4
.
0
0
±
.
0
7
8
3
3
.
6
7
±
.
0
1
4
50.02
6
7
.
3
4
±
.
1
7
8
3
8
.
4
3
±
.
2
6
5
1.08
F3
8
1
.
7
6
±
.
1
0
5
2
2
.
4
3
±
.
0
1
8
40.21
5
5
.
7
8
±
.
1
6
1
5
8
.
5
9
±
1
7
8
2.25
F4
8
4
.
8
±
.
1
4
2
1
7
.
7
9
±
.
0
1
1
33.33
5
3
.
3
7
±
.
1
3
2
4
9
.
6
7
±
.
1
8
9
1.13
F5
7
8
.
8
±
.
1
1
2
1
3
.
8
1
±
.
0
7
8
28.57
4
8
.
3
3
±
.
0
9
6
8
3
.
6
6
±
.
2
0
8
1.22
F6
8
4
.
8
±
.
0
6
9
1
8
.
2
7
±
.
0
6
3
28.21
6
4
.
7
6
±
.
1
8
9
5
6
.
6
4
±
.
2
2
8
1.49
F7
8
8
.
0
8
±
.
1
1
7
1
5
.
3
7
±
.
0
3
5
25.22
6
0
.
9
4
±
.
1
5
4
6
9
.
2
2
±
.
2
5
6
1.43
F8
8
6
.
6
8
±
.
0
9
8
1
5
.
6
9
±
.
0
2
1
26.07
6
0
.
1
8
±
.
0
8
9
7
1
.
3
4
±
.
1
5
9
1.55
F9
8
4
.
0
0
±
.
0
7
8
3
9
.
6
7
±
.
0
1
4
50.02
6
7
.
3
4
±
.
1
7
8
3
4
.
5
6
±
.
2
1
3
1.07
F10
8
6
.
9
0
±
.
0
3
5
2
0
.
8
0
±
.
0
3
2
50.00
4
1
.
6
0
±
.
1
5
3
3
9
.
0
4
±
.
1
9
4
0.89
F11
7
6
.
1
0
±
.
1
6
1
1
4
.
9
1
±
.
0
6
3
51.09
2
9
.
8
2
±
.
1
1
9
4
2
.
3
1
±
.
2
3
1
1.12
F12
8
0
.
5
0
±
.
0
7
3
1
6
.
3
4
±
.
1
2
4
50.00
3
2
.
6
8
±
.
0
9
6
4
8
.
2
1
±
.
1
7
6
1.06
Value represent mean ± SD (
𝑛
=
3
).