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ISRN Pharmacology
Volume 2012 (2012), Article ID 587160, 9 pages
doi:10.5402/2012/587160
Review Article
A Review of the Ethnobotany and Pharmacological Importance of Alstonia boonei De Wild (Apocynaceae)
1Department of Chemistry, School of Physical Sciences, University of Cape Coast, Cape Coast, Ghana
2Department of Environmental Science, School of Biological Sciences, University of Cape Coast, Cape Coast, Ghana
Received 15 April 2012; Accepted 17 May 2012
Academic Editors: T. Kumai and M. van den Buuse
Copyright © 2012 John Prosper Kwaku Adotey et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- N. Farnsworth, A. O. Akerele, A. S. Bingel, D. D. Soejarto, and Z. Guo, “Medicinal plants in therapy,” Bulletin of the World Health Organization, vol. 63, no. 6, pp. 965–981, 1985. View at Scopus
- G. Cragg and D. J. Newman, “Biodiversity: a continuing source of novel drug leads,” Pure and Applied Chemistry, vol. 77, no. 1, pp. 7–24, 2005. View at Publisher · View at Google Scholar · View at Scopus
- B.-E. Van Wyk, “A broad review of commercially important Southern African medicinal plants,” Journal of Ethnopharmacology, vol. 119, no. 3, pp. 342–355, 2008. View at Publisher · View at Google Scholar · View at Scopus
- E. Rukangira, “Overview on medicinal plants and traditional medicine in Africa,” Qualitative Health Research, vol. 14, pp. 675–690, 2004.
- M. N. B. Ayiku, Ghana Herbal Pharmacopoeia, Technology Transfer Centre, 1992.
- B. K. Gosse, T. A. Bryson, and T. Gokou, “Study of triterpenoids from Alstonia boonei,” Société Ouest-Africaine de Chimie, vol. 5, no. 8, pp. 123–128, 1999.
- D. Abbiw, Useful Plants of Ghana: West African Uses of Wild and Cultivated Plants, Intermediate Technology Publications, Royal Botanical Garden, Kew, London, 1990.
- S. Hadi and J. B. Bremner, “Initial studies on alkaloids from Lombok medicinal plants,” Molecules, vol. 6, no. 2, pp. 117–129, 2001. View at Scopus
- B. B. Fakae, A. M. Campbell, J. Barrett et al., “Inhibition of glutathione S-transferases (GSTs) from parasitic nematodes by extracts from traditional Nigerian medicinal plants,” Phytotherapy Research, vol. 14, no. 8, pp. 630–634, 2000.
- T. S. Kam, K. T. Nyeoh, K. M. Sim, and K. Yoganathan, “Alkaloids from Alstonia scholaris,” Phytochemistry, vol. 45, no. 6, pp. 1303–1305, 1997. View at Publisher · View at Google Scholar · View at Scopus
- M. Kucera, V. O. Marquis, and H. Kucerova, “Nigerian medicinal plants. I. TLC thin-layer chromatographic] separation and quantitative evaluation of Alstonia boonei alkaloids,” Planta Medica, vol. 21, no. 4, pp. 343–346, 1972. View at Scopus
- G. Croquelois, N. Kunesch, M. Debray, and J. Poisson, “Alstonia boonei alkaloids,” Medicinal Plants and Phytotherapy, vol. 6, no. 2, pp. 122–127, 1972.
- J. U. Oguakwa, “Nα-formylechitamidine, an alkaloid from Alstonia boonei,” Phytochemistry, vol. 23, no. 11, pp. 2708–2709, 1984. View at Scopus
- J. A. O. Ojewole, “Studies on the pharmacology of echitamine, an alkaloid from the stem bark of Alstonia boonei L. (Apocynaceae),” International Journal of Crude Drug Research, vol. 22, no. 3, pp. 121–143, 1984. View at Scopus
- J. A. O. Ojewole, “Autonomic pharmacology of echitamine, an alkaloid from Alstonia boonei De Wild,” Fitoterapia, vol. 54, no. 3, pp. 99–113, 1983. View at Scopus
- B. Chandrasekaran and B. Nagarajan, “Growth inhibitory effect of echitamine and plumbagin on fibrosarcoma in rats,” Arogya, vol. 9, no. 1, pp. 60–63, 1983.
- V. Saraswathi, A. C. Shyamala, S. Subramanian, and S. Govindasamy, “Studies on the effects of echitamine chloride on serum glycoproteins and lysosomal hydrolases of sarcoma-180 induced mice,” Fitoterapia, vol. 69, no. 1, pp. 73–75, 1998. View at Scopus
- V. Saraswathi, N. Ramamoorthy, S. Subramaniam, V. Mathuram, P. Gunasekaran, and S. Govindasamy, “Inhibition of glycolysis and respiration of sarcoma-180 cells by echitamine chloride,” Chemotherapy, vol. 44, no. 3, pp. 198–205, 1998. View at Publisher · View at Google Scholar · View at Scopus
- V. Saraswathi, V. Mathuram, S. Subramanian, and S. Govindasamy, “Modulation of the impaired drug metabolism in sarcoma-180 bearing mice by echitamine chloride,” Cancer Biochemistry Biophysics, vol. 17, no. 1-2, pp. 79–88, 1999. View at Scopus
- V. Saraswathi, S. Subramanian, N. Ramamoorthy, V. Mathuram, and S. Govindasamy, “In vitro cytotoxicity of echitamine chloride and adriamycin on Ehrlich ascites carcinoma cell cultures,” Medical Science Research, vol. 25, no. 3, pp. 167–170, 1997. View at Scopus
- S. Viswanathan, N. Ramamurthy, S. Subramanian, V. Mathuram, and S. Govindasamy, “Enhancement of the cytotoxic effects of Echitamine chloride by vitamin A: an in vitro study on Ehrlich ascites carcinoma cell culture,” Indian Journal of Pharmacology, vol. 29, no. 4, pp. 244–249, 1997. View at Scopus
- P. Kamarajan, N. Sekar, V. Mathuram, and S. Govindasamy, “Antitumor effect of echitamine chloride on methylcholonthrene induced fibrosarcoma in rats,” Biochemistry International, vol. 25, no. 3, pp. 491–498, 1991. View at Scopus
- N. Keawpradub, P. J. Houghton, E. Eno-Amooquaye, and P. J. Burke, “Activity of extracts and alkaloids of Thai Alstonia species against human lung cancer cell lines,” Planta Medica, vol. 63, no. 2, pp. 97–101, 1997. View at Scopus
- G. K. Biswas and G. S. Saharia, “A new alkaloidal glycoside from Alstonia scholaris,” Indian Journal of Chemistry, vol. 1, no. 1, pp. 66–67, 1978.
- T. S. Kam, K. T. Nyeoh, K. M. Sim, and K. Yoganathan, “Alkaloids from Alstonia scholaris,” Phytochemistry, vol. 45, no. 6, pp. 1303–1305, 1997. View at Publisher · View at Google Scholar · View at Scopus
- Y. Morita, M. Hesse, and H. Schmid, “Alstonia scholaris: the structure of the indole alkaloid nareline,” Helvetica Chimica Acta, vol. 60, no. 4, pp. 1419–1434, 1977. View at Scopus
- T. Yamauchi, F. Abe, W. G. Padolina, and F. M. Dayrit, “Alkaloids from leaves and bark of Alstonia scholaris in the Philippines,” Phytochemistry, vol. 29, no. 10, pp. 3321–3325, 1990. View at Publisher · View at Google Scholar · View at Scopus
- T. Yamauchi, F. Abe, R. F. Chen, G. I. Nonaka, T. Santisuk, and W. G. Padolina, “Alkaloids from the leaves of Alstonia scholaris in Taiwan, Thailand, Indonesia and the Philippines,” Phytochemistry, vol. 29, no. 11, pp. 3547–3552, 1990. View at Scopus
- T. Yamauchi and F. Abe, “Regional differences of indole alkaloids in Alstonia scholaris and Alstonia macrophylla,” International Congress Series, vol. 1157, pp. 51–58, 1998.
- W. Boonchuay and W. E. Court, “Minor alkaloids of Alstonia scholaris root,” Phytochemistry, vol. 15, no. 5, p. 821, 1976. View at Scopus
- F. Abe, R. F. Chen, T. Yamauchi, et al., Alkaloids From the Leaves of Alstonia scholaris, vol. 31, Fukuoka University, Fukuoka, Japan, 1989.
- F. Abe, R. F. Chen, T. Yamauchi, N. Marubayashi, and I. Ueda, “Studies on the constituents of Alstonia scholaris. Part I. Alschomine and isoalschomine, new alkaloids from the leaves of Alstonia scholaris,” Chemical & Pharmaceutical Bulletin, vol. 37, no. 4, pp. 887–890, 1989.
- R. Ghosh, P. Roychowdhury, D. Chattopadhyay, and Y. Iitaka, “The structure of an alkaloid, picrinine, from Alstonia scholaris,” Acta Crystallographica C, vol. 44, no. 12, pp. 2151–2154, 1988.
- J. Banerji and R. Chakrabarti, “Constituents of Alstonia schorlaris R.Br:-conversion of picrinine into strictamine and to a pyrrolidinoindolenine system,” Indian Journal of Chemistry B, vol. 23, no. 5, pp. 453–454, 1984.
- S. K. Bhattacharya, R. Bose, S. C. Dutta, A. B. Ray, and S. R. Guha, “Neuropharmacological studies on strictamine isolated from Alstonia scholaris,” Indian Journal of Experimental Biology, vol. 17, no. 6, pp. 598–600, 1979. View at Scopus
- A. Rahman and K. A. Alvi, “Indole alkaloids from Alstonia scholaris,” Phytochemistry, vol. 26, no. 7, pp. 2139–2142, 1987. View at Scopus
- A. Rahman, K. A. Alvi, S. A. Abbas, and W. Voelter, “Isolation of 19,20-Z-vallesamine and 19,20-E-vallesamine from Alstonia scholaris,” Heterocycles, vol. 26, no. 2, pp. 413–419, 1987. View at Scopus
- A. Rahman, K. A. Alvi, and A. Muzaffar, “Isolation and 1H/13C-NMR studies on 19,20-dihydrocondylocarpine: an alkaloid from the leaves of Ervatamia coronaria and Alstonia scholaris,” Planta Medica, vol. 52, no. 4, pp. 325–326, 1986. View at Scopus
- A. Banerji and A. K. Siddhanta, “Scholarine: an indole alkaloid of Alstonia scholaris,” Phytochemistry, vol. 20, no. 3, pp. 540–542, 1981. View at Scopus
- A. Banerji and J. Banerji, “Isolation of pseudoakuammigine from the leaves of Alstonia scholaris R. Br.,” Indian Journal of Chemistry B, vol. 15, no. 4, pp. 390–391, 1977.
- S. C. Dutta, S. K. Bhattacharya, and A. B. Ray, “Flower alkaloids of Alstonia scholaris,” Planta Medica, vol. 30, no. 1, pp. 86–89, 1976. View at Scopus
- W. Boonchuay and W. E. Court, “Alkaloids of Alstonia scholaris from Thailand,” Planta Medica, vol. 29, no. 4, pp. 380–390, 1976. View at Scopus
- R. C. Rastogi, R. S. Kapil, and S. P. Popli, “Picralinal—A key alkaloid of picralima group from Alstonia scholaris,” Experientia, vol. 26, no. 10, p. 1056, 1970. View at Publisher · View at Google Scholar · View at Scopus
- A. Chatterjee, B. Mukherjee, S. Ghosal, and P. K. Banerjee, “Occurrence of rhazine in Alstonia scholaris: biogenetic and chemotaxonomic significance of the co-occurrence of several indole alkaloids having a common structural pattern,” Journal of the Indian Chemical Society, vol. 46, no. 7, pp. 635–638, 1969.
- A. Rahman, M. Asif, M. Ghazala, J. Fatima, and K. A. Alvi, “Scholaricine, an alkaloid from Alstonia scholaris,” Phytochemistry, vol. 24, no. 11, pp. 2771–2773, 1985. View at Scopus
- J. Banerji, R. Mustafi, and D. J. Roy, “(-)-Scholarine and (+)-lochneridine—constituents of Alstonia scholaris R.Br. (Apocynaceae),” Indian Journal of Chemistry B, vol. 23, no. 5, p. 455, 1984.
- J. S. Chauhan, R. Chaturvedi, and S. Kumar, “Isookanin-7-O-a-L-rhamnopyranoside, a new flavanone glycoside from the roots of Alstonia scholaris R. Br.,” Indian Journal of Chemistry B, vol. 24, no. 2, p. 219, 1985.
- E. K. Desoky, “Flavonoidal contents of Alstonia scholaris R.Br,” Bulletin of Pharmaceutical Sciences, vol. 22, no. 2, pp. 117–121, 1999.
- G. B. Marini-Bettolo, M. Nicoletti, I. Messana et al., “Research on African medicinal plants-IV1 1 Part III: see ref. 1. Boonein, a new C-9 terpenoid lactone from Alstonia boonei: a possible precursor in the indole alkaloid biogenesis,” Tetrahedron, vol. 39, no. 2, pp. 323–329, 1983. View at Scopus
- E. K. Desoky, M. S. Kamel, and D. W. Bishay, “Sterols and triterpenes from Alstonia scholaris R.Br.,” Bulletin of Pharmaceutical Sciences, vol. 23, no. 1, pp. 65–71, 2000.
- I. S. Bello, T. Oduola, O. G. Adeosun, N. O. A. Omisore, G. O. Raheem, and A. A. Ademosun, “Evaluation of antimalarial activity of various fractions of Morinda lucida leaf extract and Alstonia boonei stem bark,” Global Journal of Pharmacology, vol. 3, pp. 163–165, 2009.
- G. Ebiloma, E. Amlabu, F. O. Atanu, W. Amlabu, and O. Aminu Rhoda, “Effect of the aqueous extracts of Alstonia boonei on the haematological profiles of mice experimentally infected with the chloroquine-sensitive strain of Plasmodium berghei NK-65,” Hematologia, vol. 1, pp. 11–18, 2012.
- C. Abel and K. Busia, “An exploratory ethnobotanical study of the practice of herbal medicine by the Akan peoples of Ghana,” Alternative Medicine Review, vol. 10, no. 2, pp. 112–122, 2005. View at Scopus
- O. N. Oigiangbe, I. B. Igbinosa, and M. Tamo, “Insecti cidal activity of the medicinal plant, Alstonia boonei De Wild, against Sesamia calamistis Hampson,” Journal of Zhejiang University Science B, vol. 8, no. 10, pp. 752–755, 2007. View at Publisher · View at Google Scholar · View at Scopus
- P. O. Osadebe, G. B. Okide, and I. C. Akabogu, “Study on anti-diabetic activities of crude methanolic extracts of Loranthus micranthus (Linn.) sourced from five different host trees,” Journal of Ethnopharmacology, vol. 95, no. 2-3, pp. 133–138, 2004. View at Publisher · View at Google Scholar · View at Scopus
- O. A. Olajide, S. O. Awe, J. M. Makinde et al., “Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark,” Journal of Ethnopharmacology, vol. 71, no. 1-2, pp. 179–186, 2000. View at Publisher · View at Google Scholar · View at Scopus
- G. Kweifio-Okai, D. Bird, B. Field et al., “Antiinflammatory activity of a Ghanaian antiarthritic herbal preparation: III,” Journal of Ethnopharmacology, vol. 46, no. 1, pp. 7–15, 1995. View at Publisher · View at Google Scholar · View at Scopus
- U. Asuzu and A. O. Anaga, “Pharmacological screening of the aqueous extract of Alstonia boonei bark,” Fitoterapia, vol. 63, no. 5, pp. 411–417, 1991. View at Scopus
- S. K. Adesina, “Studies on a Nigerian herbal anticonvulsant recipe,” International Journal of Crude Drug Research, vol. 20, pp. 93–100, 1982.
- O. Gabriel, N. Harrision, O. Okey, and A. Ukoha, “Changes in lipid and haematological profile of aqueous ethanolic extract of Alstonia boonei in rats,” The Internet Journal of Hematology, vol. 4, no. 1, pp. 1–5, 2008. View at Scopus
- S. O. Majekodunmi, “Formulation of the extract of the stem bark of Alstonia booneias tablet dosage form,” Tropical Journal of Pharmaceutical Research, vol. 7, no. 2, pp. 987–994, 2008.
- N. Din, S. D. Dibong, E. Mpondo Mpondo, R. J. Priso, N. F. Kwin, and A. Ngoye, “Inventory and identification of plants used in the treatment of diabetes in Douala town (Cameroon),” European Journal of Medicinal Plants, vol. 1, no. 3, pp. 60–73, 2011.
- D. Wesche, D. Black, and W. K. Milhous, in Proceedings of the 39th Annual Meeting of the American Society of Tropical Medicine and Hygiene, Book of Abstracts, no. 138, New Orleans, LA, USA, 1990.
- P. O. Adomi, “Antibacterial activity of aqueous and ethanol extracts of the stembark of Alstonia boonei and M. Iucida,” Scientific Research and Essays, vol. 1, no. 2, pp. 50–53, 2006.
- R. E. Omoregbe, O. M. Ikuebe, and I. G. Ihimire, “Antimicrobial activity of some medicinal plants extracts on Escherichia coli, Salmonella paratyphi and Shigella dysenteriae,” African Journal of Medicine and Medical Sciences, vol. 25, no. 4, pp. 373–375, 1996. View at Scopus
- O. O. Amole and O. O. Ilori, “Antimicrobial activity of the aqueous and ethanolic extracts of the stem bark of Alstonia boonei,” International Journal of Phytopharmacology, vol. 1, no. 2, pp. 119–123, 2010.
- M. M. Iwu, Handbook of African Medicinal Plants, CRC Press, London, UK, 1993.
- H. Forster, H. Niklas, and S. Lutz, “Antispasmodic effects of some medicinal plants,” Planta Medica, vol. 40, no. 4, pp. 309–319, 1980. View at Scopus
- O. B. Taiwo, B. H. Kroes, C. J. Beukelman, S. T. A. J. Horsten, J. M. Makinde, and R. P. Labadie, “Activity of the stem bark extract of Alstonia boonei de wild (apocynaceae) on human complement and polymorphonuclear leukocytes,” Journal of Ethnopharmacology, vol. 17, pp. 13–15, 1998. View at Scopus
- E. Elisabetsky and L. Costa-Campos, “The alkaloid alstonine: a review of its pharmacological properties,” Evidence-Based Complementary and Alternative Medicine, vol. 3, no. 1, pp. 39–48, 2006. View at Publisher · View at Google Scholar · View at Scopus
- A. Khaleque, K. M. Ismail, and M. Shafiullah, “Chemical investigations on Alstonia scholaris. Part I: isolation of lupeol acetate, β-sitosterol, one alkaloid and three other non-alkaloidal compounds from the bark,” Bangladesh Journal of Scientific & Industrial Research, vol. 26, no. 1–4, pp. 1–7, 1991.
- G. Kweifio-Okai, Triterpene Compounds Having Antiinflammatory and Antiarthritic Activity, PCT International, 1993.
- G. Kweifio-Okai and G. Carroll, “Antiarthritic effect of Alstonia boonei triterpenes,” Recent Advances in Toxinology Research, vol. 10, no. 3, pp. 19–28, 1992.
- G. Kweifio-Okai and A. R. Carroll, “Antiarthritic effect of lupeol acetate,” Phytotherapy Research, vol. 7, no. 2, pp. 213–215, 1993. View at Scopus
- A. Rajic, G. Kweifio-Okai, T. Macrides, R. M. Sandeman, D. S. Chandler, and G. M. Polya, “Inhibition of serine proteases by anti-inflammatory triterpenoids,” Planta Medica, vol. 66, no. 3, pp. 206–210, 2000. View at Publisher · View at Google Scholar · View at Scopus
- G. Kweifio-Okai, “Antiinflammatory activity of a Ghanaian antiarthritic herbal preparation: I,” Journal of Ethnopharmacology, vol. 33, no. 3, pp. 263–267, 1991. View at Scopus
- G. Kweifio-Okai, “Antiinflammatory activity of a Ghanaian antiarthritic herbal preparation: II,” Journal of Ethnopharmacology, vol. 33, no. 1-2, pp. 129–133, 1991. View at Scopus
- A. Odeku, “Formulation of the extract of the stem bark of Alstonia boonei,” Tropical Journal of Pharmaceutical Research, vol. 7, no. 2, pp. 987–994, 2008.
- T. O. Odugbemi, O. R. Akinsulire, I. E. Aibinu, and P. O. Fabeku, “Medicinal plants useful for malaria therapy in Okeigbo, Ondo State, Southwest Nigeria,” African Journal of Traditional, Complementary and Alternative Medicines, vol. 4, no. 2, pp. 191–198, 2007. View at Scopus