| | The 1st Law of Autoimmunity.All autoimmune diseases are triggered by microbial infections. |
| | The 2nd Law of Autoimmunity.Autoimmunity, the reaction between a host component and the receptor for antigen on a lymphocyte or antibody, occurs due to a semi-random change in the DNA sequence of a lymphocyte V gene.Burnet’s Forbidden Clone Theory, BMJ 1959, confirmed by Knight et al JCEM 1986, Adams et al in Thyroid Autoimmunity 1987. |
| | The 3rd Law of Autoimmunity.Histocompatibility antigens, major, minor and HY, protect from autoimmunity with imperfect success, by deleting nascent lymphocyte clones with complementary receptors for antigen. Adams and Knight’s H Gene Theory, Lancet 1980.Adams Lancet 1987, Knight and Adams Ciba Foundation Symposium 1982. |
| | The 4th Law of Autoimmune disease. In a population of people, a balanced genetic polymorphism of H and V genes, driven bt reproductive disadvantage, minimises infectious and autoimmune diseases. |
| | A corollary of the 4th Law is that non-pathogenic autoimmunity, having no reproductive disadvantage, occurs much more commonly than pathogenic autoimmunity. |
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