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| Back pain ≥3 months and age <45 years ET |
| Sacroiliitis by MRI or radiography* + 1 other feature | OR | HLA B27 + 2 other features |
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| Features of axial SpA | | |
| Inflammatory back pain | 4 of the 5 following characteristics | |
| Age <40 years | |
| Insidious onset | |
| Improvement with exercise | |
| No improvement with rest | |
| Pain at night | |
| Arthritis | Past or present active synovitis diagnosed by a physician | |
| Enthesitis | Pain spontaneously or upon palpation of the Achilles tendon insertion site or plantar fascia | |
| Uveitis | Past or present anterior uveitis diagnosed by a physician | |
| Dactylitis | Past or present active dactylitis diagnosed by a physician | |
| Psoriasis | Past or present active psoriasis diagnosed by a physician | |
| Crohn's disease/ulcerative colitis | Past or present, diagnosed by a physician | |
| Good response to NSAIDs | 24–48 h after the initiation of full-dose NSAID therapy, the pain is gone or much better | |
| Family history for SpA | First- or second-degree relative with any of the following: SpA, psoriasis, acute uveitis, reactive arthritis, chronic inflammatory bowel disease | |
| HLA-B27 | Presence of B27 | |
| Elevated CRP | CRP above the upper limit of the normal range, in the absence of another cause of CRP elevation | |
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