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Linked References

1. L. G. Costa, “Neurotoxicity testing: a discussion of in vitro alternatives,” Environmental Health Perspectives, vol. 106, supplement 2, pp. 505–510, 1998. View at Scopus
2. ECETOC, Evaluation of the Neurotoxic Potential of Chemicals, European Center for Ecotoxicology and Toxicology of Chemicals, Brussels, Belgium, 1992.
3. P. Grandjean and P. J. Landrigan, “Developmental neurotoxicity of industrial chemicals,” The Lancet, vol. 368, no. 9553, pp. 2167–2178, 2006. View at Publisher · View at Google Scholar · View at Scopus
4. L. G. Costa and G. Giordano, “Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants,” NeuroToxicology, vol. 28, no. 6, pp. 1047–1067, 2007. View at Publisher · View at Google Scholar · View at Scopus
5. K. M. Crofton, “Thyroid disrupting chemicals: mechanisms and mixtures,” International Journal of Andrology, vol. 31, no. 2, pp. 209–223, 2008. View at Publisher · View at Google Scholar · View at Scopus
6. OECD (Organization for Economic Co-operation and Development), “Test guideline 424. OECD guideline for testing of chemicals,” Neurotoxicity Study in Rodents, OECD, Paris, france, 1997.
7. USEPA (United States Environmental Protection Agency), “Health effects test guidelines. OPPTS 870.6200,” Neurotoxicity Screening Battery, USEPA, Washington, DC, USA, 1998.
8. USEPA (United States Environmental Protection Agency), “Health effects test guidelines. OPPTS 870.6300,” Developmental Neurotoxicity Study, USEPA, Washington, DC, USA, 1998.
9. OECD (Organization for Economic Co-operation and Development), “Test guideline 426. OECD guideline for testing of chemicals,” Developmental Neurotoxicity Study, OECD, Paris, France, 2007.
10. S. L. Makris, K. Raffaele, S. Allen et al., “A retrospective performance assessment of the developmental neurotoxicity study in support of OECD test guideline 426,” Environmental Health Perspectives, vol. 117, no. 1, pp. 17–25, 2009. View at Publisher · View at Google Scholar · View at Scopus
11. L. Claudio, W. C. Kwa, A. L. Russell, and D. Wallinga, “Testing methods for developmental neurotoxicity of environmental chemicals,” Toxicology and Applied Pharmacology, vol. 164, no. 1, pp. 1–14, 2000. View at Publisher · View at Google Scholar · View at Scopus
12. D. A. Cory-Slechta, K. M. Crofton, J. A. Foran et al., “Methods to identify and characterize developmental neurotoxicity for human health risk assessment. I: behavioral effects,” Environmental Health Perspectives, vol. 109, supplement 1, pp. 79–91, 2001. View at Scopus
13. W. Kaufmann, “Current status of developmental neurotoxicity: an industry perspective,” Toxicology Letters, vol. 140-141, pp. 161–169, 2003. View at Publisher · View at Google Scholar · View at Scopus
14. A. A. Li, “Regulatory developmental neurotoxicology testing: data evaluation for risk assessment purposes,” Environmental Toxicology and Pharmacology, vol. 19, no. 3, pp. 727–733, 2005. View at Publisher · View at Google Scholar · View at Scopus
15. L. G. Costa, G. Giordano, and M. Guizzetti, “Predictive models for neurotoxicity assessment,” in Predictive Toxicology in Drug Safety, J. J. Xu and L. Urban, Eds., pp. 135–152, Cambridge University Press, 2011.
16. S. A. Bayer, J. Altman, R. J. Russo, and X. Zhang, “Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat,” NeuroToxicology, vol. 14, no. 1, pp. 83–144, 1993. View at Scopus
17. P. M. Rodier, “Vulnerable periods and processes during central nervous system development,” Environmental Health Perspectives, vol. 102, supplement 2, pp. 121–124, 1994. View at Scopus
18. L. G. Costa, M. Aschner, A. Vitalone, T. Syversen, and O. P. Soldin, “Developmental neuropathology of environmental agents,” Annual Review of Pharmacology and Toxicology, vol. 44, pp. 87–110, 2004. View at Publisher · View at Google Scholar · View at Scopus
19. P. M. Rodier, “Developing brain as a target of toxicity,” Environmental Health Perspectives, vol. 103, supplement 6, pp. 73–76, 1995. View at Scopus
20. L. Nguyen, J. M. Rigo, V. Rocher et al., “Neurotransmitters as early signals for central nervous system development,” Cell and Tissue Research, vol. 305, no. 2, pp. 187–202, 2001. View at Publisher · View at Google Scholar · View at Scopus
21. E. M. Johnson and T. L. Deckwerth, “Molecular mechanisms of developmental neuronal death,” Annual Review of Neuroscience, vol. 16, pp. 31–46, 1993. View at Scopus
22. C. Ikonomidou, P. Bittigau, C. Koch et al., “Neurotransmitters and apoptosis in the developing brain,” Biochemical Pharmacology, vol. 62, no. 4, pp. 401–405, 2001. View at Publisher · View at Google Scholar · View at Scopus
23. S. J. Webb, C. S. Monk, and C. A. Nelson, “Mechanisms of postnatal neurobiological development: implications for human development,” Developmental Neuropsychology, vol. 19, no. 2, pp. 147–171, 2001. View at Scopus
24. M. Aschner and L. G. Costa, The Role of Glia in Neurotoxicity, CRC Press, Boca Raton, Fla, USA, 2nd edition, 2004.
25. P. van den Hazel, M. Zuurbier, W. Babisch et al., “Today's epidemics in children: possible relations to environmental pollution and suggested preventive measures,” Acta Paediatrica, vol. 95, supplement 453, pp. 18–25, 2006. View at Publisher · View at Google Scholar · View at Scopus
26. A. Miodovnik, “Environmental neurotoxicants and developing brain,” Mount Sinai Journal of Medicine, vol. 78, no. 1, pp. 58–77, 2011. View at Publisher · View at Google Scholar · View at Scopus
27. T. W. Clarkson and L. Magos, “The toxicology of mercury and its chemical compounds,” Critical Reviews in Toxicology, vol. 36, no. 8, pp. 609–662, 2006. View at Publisher · View at Google Scholar · View at Scopus
28. A. F. Castoldi, C. Johansson, N. Onishchenko et al., “Human developmental neurotoxicity of methylmercury: impact of variables and risk modifiers,” Regulatory Toxicology and Pharmacology, vol. 51, no. 2, pp. 201–214, 2008. View at Publisher · View at Google Scholar · View at Scopus
29. A. F. Castoldi, N. Onishchenko, C. Johansson et al., “Developmental neurotoxicity of methylmercury: laboratory animal adata and their contribution to risk assessment,” Regulatory Toxicology and Pharmacology, vol. 51, no. 2, pp. 215–229, 2008. View at Publisher · View at Google Scholar · View at Scopus
30. P. Grandjean and K. T. Herz, “Methylmercury and brain development: imprecision and underestimation of developmental neurotoxicity in humans,” Mount Sinai Journal of Medicine, vol. 78, no. 1, pp. 107–118, 2011. View at Publisher · View at Google Scholar · View at Scopus
31. M. Harada, “Minamata disease: methylmercury poisoning in Japan caused by environmental pollution,” Critical Reviews in Toxicology, vol. 25, no. 1, pp. 1–24, 1995. View at Scopus
32. F. Bakir, S. F. Damluji, I. Amin Zaki, et al., “Methylmercury poisoning in Iraq,” Science, vol. 181, no. 4096, pp. 230–241, 1973. View at Scopus
33. T. Takeuchi, “Pathology of Minamata disease. With special reference to its pathogenesis,” Acta Pathologica Japonica, vol. 32, supplement 1, pp. 73–99, 1982. View at Scopus
34. T. M. Burbacher, P. M. Rodier, and B. Weiss, “Methylmercury developmental neurotoxicity: a comparison of effects in humans and animals,” Neurotoxicology and Teratology, vol. 12, no. 3, pp. 191–202, 1990. View at Publisher · View at Google Scholar · View at Scopus
35. T. Kjellstrom, P. Kennedy, S. Wallis, A. Stewart, L. Friberg, and B. Linf, “Physical and mental development ofchildren with prenatal exposure to mercury from fish. Stage II interviews and psychological tests at age 6 ( 3642),” National Swedish Environmental Protection Board Report, Stockholm, Sweden, 1989.
36. P. Grandjean, P. Weihe, R. F. White et al., “Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury,” Neurotoxicology and Teratology, vol. 19, no. 6, pp. 417–428, 1997. View at Publisher · View at Google Scholar · View at Scopus
37. G. J. Myers, P. W. Davidson, C. Cox et al., “Prenatal methylmercury exposure from ocean fish consumption in the seychelles child development study,” The Lancet, vol. 361, no. 9370, pp. 1686–1692, 2003. View at Publisher · View at Google Scholar · View at Scopus
38. P. W. Davidson, G. J. Myers, C. Cox et al., “Methylmercury and neurodevelopment: longitudinal analysis of the seychelles child development cohort,” Neurotoxicology and Teratology, vol. 28, no. 5, pp. 529–535, 2006. View at Publisher · View at Google Scholar · View at Scopus
39. D. C. Rice, “Identification of functional domains affected by developmental exposure to methylmercury: faroe islands and related studies,” NeuroToxicology, vol. 21, no. 6, pp. 1039–1044, 2000. View at Scopus
40. T. W. Clarkson and J. J. Strain, “Nutritional factors may modify the toxic action of methyl mercury in fish-eating populations,” Journal of Nutrition, vol. 133, no. 5, supplement 1, pp. 1539S–1543S, 2003. View at Scopus
41. L. G. Costa, “Contaminants in fish: risk-benefit considerations,” Arhiv za Higijenu Rada i Toksikologiju, vol. 58, no. 3, pp. 367–374, 2007. View at Publisher · View at Google Scholar · View at Scopus
42. FAO (Food and Agriculture Organization), Report of the Joint FAO/WHO Expert Consultation on the Risks and Benefits of Fish Consumption, WHO, Geneva, Switzerland, 2011.
43. H. L. Needleman, C. Gunnoe, and A. Leviton, “Deficits in psychologic and classroom performance of children with elevated dentine lead levels,” The New England Journal of Medicine, vol. 300, no. 13, pp. 689–695, 1979. View at Scopus
44. R. L. Canfield, C. R. Henderson, D. A. Cory-Slechta, C. Cox, T. A. Jusko, B. P. Lamphear, et al., “Intellectual impairment in children with blood lead concentrations below 10 μg/dL,” The New England Journal of Medicine, vol. 112, pp. 1308–1313, 2003.
45. B. P. Lanphear, R. Hornung, J. Khoury et al., “Low-level environmental lead exposure and children's intellectual function: an international pooled analysis,” Environmental Health Perspectives, vol. 113, no. 7, pp. 894–899, 2005. View at Publisher · View at Google Scholar · View at Scopus
46. S. G. Gilbert and B. Weiss, “A rationale for lowering the blood lead action level from 10 to 2 μg/dL,” NeuroToxicology, vol. 27, no. 5, pp. 693–701, 2006. View at Publisher · View at Google Scholar · View at Scopus
47. P. Grandjean, “Even low-dose lead exposure is hazardous,” The Lancet, vol. 376, no. 9744, pp. 855–856, 2010. View at Publisher · View at Google Scholar · View at Scopus
48. J. M. Davis, D. A. Otto, D. E. Weil, and L. D. Grant, “The comparative developmental neurotoxicity of lead in humans and animals,” Neurotoxicology and Teratology, vol. 12, no. 3, pp. 215–229, 1990. View at Publisher · View at Google Scholar · View at Scopus
49. T. R. Guilarte, C. D. Toscano, J. L. McGlothan, and S. A. Weaver, “Environmental enrichment reverses cognitive and molecular deficits induced by developmental lead exposure,” Annals of Neurology, vol. 53, no. 1, pp. 50–56, 2003. View at Publisher · View at Google Scholar · View at Scopus
50. R. J. Bull, P. T. McCauley, D. H. Taylor, and K. M. Croften, “The effects of lead on the developing central nervous system of the rat,” NeuroToxicology, vol. 4, no. 1, pp. 1–17, 1983. View at Scopus
51. A. Oberto, N. Marks, H. L. Evans, and A. Guidotti, “Lead (Pb⁺²) promotes apoptosis in newborn rat cerebellar neurons: pathological implications,” Journal of Pharmacology and Experimental Therapeutics, vol. 279, no. 1, pp. 435–442, 1996. View at Scopus
52. A. M. Gebhart and G. W. Goldstein, “Use of an in vitro system to study the effects of lead on astrocyte-endothelial cell interactions: a model for studying toxic injury to the blood-brain barrier,” Toxicology and Applied Pharmacology, vol. 94, no. 2, pp. 191–206, 1988. View at Scopus
53. Y. Finkelstein, M. E. Markowitz, and J. F. Rosen, “Low-level lead-induced neurotoxicity in children: an update on central nervous system effects,” Brain Research Reviews, vol. 27, no. 2, pp. 168–176, 1998. View at Publisher · View at Google Scholar · View at Scopus
54. T. J. Simons, “Lead-calcium interactions in cellular lead toxicity,” NeuroToxicology, vol. 14, no. 2-3, pp. 77–85, 1993. View at Scopus
55. J. Markovac and G. W. Goldstein, “Picomolar concentrations of lead stimulate brain protein kinase C,” Nature, vol. 334, no. 6177, pp. 71–73, 1988. View at Scopus
56. H. Lu, M. Guizzetti, and L. G. Costa, “Inorganic lead stimulates DNA synthesis in human astrocytoma cells: role of protein kinase Cα,” Journal of Neurochemistry, vol. 78, no. 3, pp. 590–599, 2001. View at Publisher · View at Google Scholar · View at Scopus
57. P. Fürst, “Dioxins, polychlorinated biphenyls and other organohalogen compounds in human milk,” Molecular Nutrition and Food Research, vol. 50, no. 10, pp. 922–933, 2006. View at Publisher · View at Google Scholar · View at Scopus
58. R. J. Law, C. R. Allchin, J. de Boer et al., “Levels and trends of brominated flame retardants in the European environment,” Chemosphere, vol. 64, no. 2, pp. 187–208, 2006. View at Publisher · View at Google Scholar · View at Scopus
59. USEPA (United States Environmental Protection Agency), An Exposure Assessment of Polybrominated Diphenyl Ethers, USEPA, Washington, DC, USA, 2010.
60. M. Lorber, “Exposure of Americans to polybrominated diphenyl ethers,” Journal of Exposure Science and Environmental Epidemiology, vol. 18, no. 1, pp. 2–19, 2008. View at Publisher · View at Google Scholar · View at Scopus
61. D. Fischer, K. Hooper, M. Athanasiadou, I. Athanassiadis, and A. Bergman, “Children show highest levels of polybrominated diphenyl ethers in a California family of four: a case study,” Environmental Health Perspectives, vol. 114, no. 10, pp. 1581–1584, 2006. View at Publisher · View at Google Scholar · View at Scopus
62. L. M. Toms, F. Harden, O. Paepke, P. Hobson, J. J. Ryan, and J. F. Mueller, “Higher accumulation of polybrominated diphenyl ethers in infants than in adults,” Environmental Science and Technology, vol. 42, no. 19, pp. 7510–7515, 2008. View at Publisher · View at Google Scholar · View at Scopus
63. P. Eriksson, E. Jakobsson, and A. Fredriksson, “Brominated flame retardants: a novel class of developmental neurotoxicants in our environment?” Environmental Health Perspectives, vol. 109, no. 9, pp. 903–908, 2001. View at Scopus
64. I. Branchi, F. Capone, E. Alleva, and L. G. Costa, “Polybrominated diphenyl ethers: neurobehavioral effects following developmental exposure,” NeuroToxicology, vol. 24, no. 3, pp. 449–462, 2003. View at Publisher · View at Google Scholar · View at Scopus
65. L. S. Birnbaum and D. F. Staskal, “Brominated flame retardants: cause for concern?” Environmental Health Perspectives, vol. 112, no. 1, pp. 9–17, 2004. View at Scopus
66. T. A. McDonald, “Polybrominated diphenylether levels among United States residents: daily intake and risk of harm to the developing brain and reproductive organs,” Integrated Environmental Assessment and Management, vol. 1, no. 4, pp. 343–354, 2005. View at Publisher · View at Google Scholar · View at Scopus
67. M. M. Dingemans, M. van den Berg, and R. H. S. Westerink, “Neurotoxicity of brominated flame retardants: (in)direct effects of parent and hydroxylated polybrominated diphenyl ethers on the (developing) nervous system,” Environmental Health Perspectives, vol. 119, no. 7, pp. 900–907, 2011. View at Publisher · View at Google Scholar · View at Scopus
68. L. G. Costa and G. Giordano, “Is decabromodiphenyl ether (BDE-209) a developmental neurotoxicant?” NeuroToxicology, vol. 32, pp. 9–24, 2011. View at Publisher · View at Google Scholar · View at Scopus
69. D. F. Staskal, J. J. Diliberto, and L. S. Birnbaum, “Disposition of BDE 47 in developing mice,” Toxicological Sciences, vol. 90, no. 2, pp. 309–316, 2006. View at Publisher · View at Google Scholar · View at Scopus
70. H. R. Chao, S. L. Wang, W. J. Lee, Y. F. Wang, and O. Päpke, “Levels of polybrominated diphenyl ethers (PBDEs) in breast milk from central Taiwan and their relation to infant birth outcome and maternal menstruation effects,” Environment International, vol. 33, no. 2, pp. 239–245, 2007. View at Publisher · View at Google Scholar · View at Scopus
71. E. Roze, L. Meijer, A. Bakker, K. N. J. A. van Braeckel, P. J. J. Sauer, and A. F. Bos, “Prenatal exposure to organohalogens, including brominated flame retardants, influences motor, cognitive, and behavioral performance at school age,” Environmental Health Perspectives, vol. 117, no. 12, pp. 1953–1958, 2009. View at Publisher · View at Google Scholar · View at Scopus
72. J. B. Herbstman, A. Sjödin, M. Kurzon et al., “Prenatal exposure to PBDEs and neurodevelopment,” Environmental Health Perspectives, vol. 118, no. 5, pp. 712–719, 2010. View at Publisher · View at Google Scholar · View at Scopus
73. M. Gascon, M. Vrijheid, D. Martínez et al., “Effects of pre and postnatal exposure to low levels of polybromodiphenyl ethers on neurodevelopment and thyroid hormone levels at 4 years of age,” Environment International, vol. 37, no. 3, pp. 605–611, 2011. View at Publisher · View at Google Scholar · View at Scopus
74. H. R. Chao, T.C. Tsou, H. L. Huang, and G. P. Chang-Chien, “Levels of breast milk PBDEs from Southern Taiwan and their potential impact on neurodevelopment,” Pediatric Research, vol. 70, pp. 596–600, 2011.
75. J. A. Biesemeier, M. J. Beck, H. Silberberg et al., “An oral developmental neurotoxicity study of decabromodiphenyl ether (DecaBDE) in rats,” Birth Defects Research B, vol. 92, no. 1, pp. 17–35, 2011. View at Publisher · View at Google Scholar · View at Scopus
76. T. Zhou, M. M. Taylor, M. J. De Vito, and K. M. Crofton, “Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption,” Toxicological Sciences, vol. 66, no. 1, pp. 105–116, 2002. View at Publisher · View at Google Scholar · View at Scopus
77. J. R. Gee, J. M. Hedge, and V. C. Moser, “Lack of alterations in thyroid hormones following exposure to polybrominated diphenyl ether 47 during a period of rapid brain development in mice,” Drug and Chemical Toxicology, vol. 31, no. 2, pp. 245–254, 2008. View at Publisher · View at Google Scholar · View at Scopus
78. F. Madia, G. Giordano, V. Fattori et al., “Differential in vitro neurotoxicity of the flame retardant PBDE-99 and of the PCB aroclor 1254 in human astrocytoma cells,” Toxicology Letters, vol. 154, no. 1-2, pp. 11–21, 2004. View at Publisher · View at Google Scholar · View at Scopus
79. P. R. S. Kodavanti and T. R. Ward, “Differential effects of commercial polybrominated diphenyl ether and polychlorinated biphenyl mixtures on intracellular signaling in rat brain in vitro,” Toxicological Sciences, vol. 85, no. 2, pp. 952–962, 2005. View at Publisher · View at Google Scholar · View at Scopus
80. P. He, W. He, A. Wang et al., “PBDE-47-induced oxidative stress, DNA damage and apoptosis in primary cultured rat hippocampal neurons,” NeuroToxicology, vol. 29, no. 1, pp. 124–129, 2008. View at Publisher · View at Google Scholar · View at Scopus
81. G. Giordano, T. J. Kavanagh, and L. G. Costa, “Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels,” Toxicology and Applied Pharmacology, vol. 232, no. 2, pp. 161–168, 2008. View at Publisher · View at Google Scholar · View at Scopus
82. S. C. Huang, G. Giordano, and L. G. Costa, “Comparative cytotoxicity and intracellular accumulation of five polybrominated diphenyl ether congeners in mouse cerebellar granule neurons,” Toxicological Sciences, vol. 114, no. 1, pp. 124–132, 2010. View at Publisher · View at Google Scholar · View at Scopus
83. K. H. Kim, D. D. Bose, A. Ghogha et al., “Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity,” Environmental Health Perspectives, vol. 119, no. 4, pp. 519–526, 2011. View at Publisher · View at Google Scholar · View at Scopus
84. NRC (National Research Council), Pesticides in the Diet of Infants and Children, National Academy Press, Washington, DC, USA, 1993.
85. FQPA (Food Quality Protection Act), “Public law 104–170,” 1996.
86. L. G. Costa, “Toxic effects of pesticides,” in Casarett and Doull's Toxicology: The Basic Science of Poisons, C. D. Klaassen, Ed., pp. 883–930, McGraw-Hill, New York, NY, USA, 7th edition, 2008.
87. C. N. Pope and J. Liu, “Age-related differences in sensitivity to organophosphorus pesticides,” Environmental Toxicology and Pharmacology, vol. 4, no. 3-4, pp. 309–314, 1997. View at Publisher · View at Google Scholar · View at Scopus
88. L. G. Costa, “Current issues in organophosphate toxicology,” Clinica Chimica Acta, vol. 366, no. 1-2, pp. 1–13, 2006. View at Publisher · View at Google Scholar · View at Scopus
89. G. M. Benke and S. D. Murphy, “The influence of age on the toxicity and metabolism of methyl parathion and parathion in male and female rats,” Toxicology and Applied Pharmacology, vol. 31, no. 2, pp. 254–269, 1975. View at Scopus
90. S. R. Mortensen, S. M. Chanda, M. J. Hooper, and S. Padilla, “Maturational differences in chlorpyrifos-oxonase activity may contribute to age-related sensitivity to chlorpyrifos,” Journal of Biochemical Toxicology, vol. 11, no. 6, pp. 279–287, 1996. View at Scopus
91. T. B. Cole, R. L. Jampsa, B. J. Walter et al., “Expression of human paraoxonase (PON1) during development,” Pharmacogenetics, vol. 13, no. 6, pp. 357–364, 2003. View at Publisher · View at Google Scholar · View at Scopus
92. X. Song, F. J. Seidler, J. L. Saleh, J. Zhang, S. Padilla, and T. A. Slotkin, “Cellular mechanisms for developmental toxicity of chlorpyrifos: targeting the adenylyl cyclase signaling cascade,” Toxicology and Applied Pharmacology, vol. 145, no. 1, pp. 158–174, 1997. View at Publisher · View at Google Scholar · View at Scopus
93. K. Dam, F. J. Seidler, and T. A. Slotkin, “Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity,” Developmental Brain Research, vol. 121, no. 2, pp. 179–187, 2000. View at Publisher · View at Google Scholar · View at Scopus
94. J. E. Aldridge, F. J. Seidler, A. Meyer, I. Thillai, and T. A. Slotkin, “Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods,” Environmental Health Perspectives, vol. 111, no. 14, pp. 1736–1743, 2003. View at Scopus
95. L. Ricceri, N. Markina, A. Valanzano et al., “Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice,” Toxicology and Applied Pharmacology, vol. 191, no. 3, pp. 189–201, 2003. View at Publisher · View at Google Scholar · View at Scopus
96. M. Guizzetti, S. Pathak, G. Giordano, and L. G. Costa, “Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation,” Toxicology, vol. 215, no. 3, pp. 182–190, 2005. View at Publisher · View at Google Scholar · View at Scopus
97. A. Caughlan, K. Newhouse, U. Namgung, and Z. Xia, “Chlorphyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases,” Toxicological Sciences, vol. 78, no. 1, pp. 125–134, 2004. View at Publisher · View at Google Scholar · View at Scopus
98. D. L. Eaton, R. B. Daroff, H. Autrup et al., “Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment,” Critical Reviews in Toxicology, vol. 38, supplement 2, pp. 1–125, 2008. View at Publisher · View at Google Scholar · View at Scopus
99. A. S. Howard, R. Bucelli, D. A. Jett, D. Bruun, D. Yang, and P. J. Lein, “Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal cultures,” Toxicology and Applied Pharmacology, vol. 207, no. 2, pp. 112–124, 2005. View at Publisher · View at Google Scholar · View at Scopus
100. P. J. Landrigan, L. Claudio, S. B. Markowitz et al., “Pesticides and inner-city children: exposures, risks, and prevention,” Environmental Health Perspectives, vol. 107, supplement 3, pp. 431–437, 1999. View at Scopus
101. C. Lu, G. Kedan, J. Fisker-Andersen, J. C. Kissel, and R. A. Fenske, “Multipathway organophosphorus pesticide exposures of preschool children living in agricultural and nonagricultural communities,” Environmental Research, vol. 96, no. 3, pp. 283–289, 2004. View at Publisher · View at Google Scholar · View at Scopus
102. B. Eskenazi, A. Bradman, and R. Castorina, “Exposures of children to organophosphate pesticides and their potential adverse health effects,” Environmental Health Perspectives, vol. 107, supplement 3, pp. 409–419, 1999. View at Scopus
103. M. Bjørling-Poulsen, H. R. Andersen, and P. Grandjean, “Potential developmental neurotoxicity of pesticides used in Europe,” Environmental Health, vol. 7, article 50, 2008. View at Publisher · View at Google Scholar · View at Scopus
104. K. C. Raffaele, J. Rowland, B. May, S. L. Makris, K. Schumacher, and L. J. Scarano, “The use of developmental neurotoxicity data in pesticide risk assessments,” Neurotoxicology and Teratology, vol. 32, no. 5, pp. 563–572, 2010. View at Publisher · View at Google Scholar · View at Scopus
105. V. A. Rauh, R. Garfinkel, F. P. Perera et al., “Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children,” Pediatrics, vol. 118, no. 6, pp. e1845–e1859, 2006. View at Publisher · View at Google Scholar · View at Scopus
106. B. Eskenazi, A. R. Marks, A. Bradman et al., “Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children,” Environmental Health Perspectives, vol. 115, no. 5, pp. 792–798, 2007. View at Publisher · View at Google Scholar · View at Scopus
107. S. M. Engel, J. Wetmur, J. Chen et al., “Prenatal exposure to organophosphates, paraoxonase 1, and cognitive development in childhood,” Environmental Health Perspectives, vol. 119, no. 8, pp. 1182–1188, 2011. View at Publisher · View at Google Scholar · View at Scopus
108. R. L. Prueitt, J. E. Goodman, L. A. Bailey, and R. R. Rhomberg, “Hypothesis-based weight of evidence evaluation of the neurodevelopmental effects of chlorpyrifos,” Critical Reviews in Toxicology, vol. 41, pp. 822–903, 2011.
109. K. R. Reuhl, “Delayed expression of neurotoxicity: the problem of silent damage,” NeuroToxicology, vol. 12, no. 3, pp. 341–346, 1991. View at Scopus
110. P. Grandjean, “Late insights into early origins of disease,” Basic and Clinical Pharmacology and Toxicology, vol. 102, no. 2, pp. 94–99, 2008. View at Publisher · View at Google Scholar · View at Scopus
111. B. Weiss, “Cancer and the dynamics of neurodegenerative processes,” NeuroToxicology, vol. 12, no. 3, pp. 379–386, 1991. View at Scopus
112. Z. X. Zhang, D. W. Anderson, L. Lavine, and N. Mantel, “Patterns of acquiring parkinsonism-dementia complex on guam. 1944 through 1985,” Archives of Neurology, vol. 47, no. 9, pp. 1019–1024, 1990. View at Scopus
113. C. MacKnight, “Clinical implications of bovine spongiform encephalopathy,” Clinical Infectious Diseases, vol. 32, no. 12, pp. 1726–1731, 2001. View at Publisher · View at Google Scholar · View at Scopus
114. K. M. Godfrey and D. J. P. Barker, “Fetal programming and adult health,” Public Health Nutrition, vol. 4, no. 2, pp. 611–624, 2001. View at Scopus
115. S. H. Swan, “Intrauterine exposure to diethylstilbestrol: long-term effects in humans,” Acta Pathologica, Microbiologica, et Immunologica Scandinavica, vol. 108, no. 12, pp. 793–804, 2000. View at Scopus
116. Z. D. Ling, D. A. Gayle, S. Y. Ma et al., “In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain,” Movement Disorders, vol. 17, no. 1, pp. 116–124, 2002. View at Publisher · View at Google Scholar · View at Scopus
117. L. W. Fan, L. T. Tien, B. Zheng et al., “Dopaminergic neuronal injury in the adult rat brain following neonatal exposure to lipopolysaccharide and the silent neurotoxicity,” Brain, Behavior, and Immunity, vol. 25, no. 2, pp. 286–297, 2011. View at Publisher · View at Google Scholar · View at Scopus
118. P. J. Landrigan, B. Sonawane, R. N. Butler, L. Trasande, R. Callan, and D. Droller, “Early environmental origins of neurodegenerative disease in later life,” Environmental Health Perspectives, vol. 113, no. 9, pp. 1230–1233, 2005. View at Publisher · View at Google Scholar · View at Scopus
119. D. A. Cory-Slechta, M. Thiruchelvam, E. K. Richfield, B. K. Barlow, and A. I. Brooks, “Developmental pesticide exposures and the Parkinson's disease phenotype,” Birth Defects Research A, vol. 73, no. 3, pp. 136–139, 2005. View at Publisher · View at Google Scholar · View at Scopus
120. J. R. Richardson, W. M. Caudle, M. Wang, E. D. Dean, K. D. Pennell, and G. W. Miller, “Developmental exposure to the pesticide dieldrin alters the dopamine system and increases neurotoxicity in an animal model of Parkinson's disease,” FASEB Journal, vol. 20, no. 10, pp. E976–E985, 2006. View at Publisher · View at Google Scholar · View at Scopus
121. M. C. Newland and E. B. Rasmussen, “Aging unmasks adverse effects of gestational exposure to methylmercury in rats,” Neurotoxicology and Teratology, vol. 22, no. 6, pp. 819–828, 2000. View at Publisher · View at Google Scholar · View at Scopus
122. B. Weiss, T. W. Clarkson, and W. Simon, “Silent latency periods in methylmercury poisoning and in neurodegenerative disease,” Environmental Health Perspectives, vol. 110, no. 5, pp. 851–854, 2002. View at Scopus
123. M. H. Lee and A. Rabe, “Premature decline in Morris water maze performance of aging micrencephalic rats,” Neurotoxicology and Teratology, vol. 14, no. 6, pp. 383–392, 1992. View at Publisher · View at Google Scholar · View at Scopus
124. S. Barone, M. E. Stanton, and W. R. Mundy, “Neurotoxic effects of neonatal triethyltin (TET) exposure are exacerbated with aging,” Neurobiology of Aging, vol. 16, no. 5, pp. 723–735, 1995. View at Publisher · View at Google Scholar · View at Scopus
125. A. Vitalone, A. Catalani, C. Cinque et al., “Long-term effects of developmental exposure to low doses of PCB 126 and methylmercury during development,” Toxicology Letters, vol. 197, no. 1, pp. 38–45, 2010. View at Publisher · View at Google Scholar · View at Scopus
126. L. D. White, D. A. Cory-Slechta, M. E. Gilbert et al., “New and evolving concepts in the neurotoxicology of lead,” Toxicology and Applied Pharmacology, vol. 225, no. 1, pp. 1–27, 2007. View at Publisher · View at Google Scholar · View at Scopus
127. M. G. Opler, S. L. Buka, J. Groeger et al., “Prenatal exposure to lead, δ-aminolevulinic acid, and schizophrenia: further evidence,” Environmental Health Perspectives, vol. 116, no. 11, pp. 1586–1590, 2008. View at Scopus
128. J. Wu, M. R. Basha, B. Brock et al., “Alzheimer's Disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD,” Journal of Neuroscience, vol. 28, no. 1, pp. 3–9, 2008. View at Publisher · View at Google Scholar · View at Scopus
129. N. H. Zawia and M. R. Basha, “Environmental risk factors and the developmental basis for Alzheimer's disease,” Reviews in the Neurosciences, vol. 16, no. 4, pp. 325–337, 2005. View at Scopus
130. M. R. Basha, W. Wei, S. A. Bakheet et al., “The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and β-amyloid in the aging brain,” Journal of Neuroscience, vol. 25, no. 4, pp. 823–829, 2005. View at Publisher · View at Google Scholar · View at Scopus
131. R. Basha and G. R. Reddy, “Developmental exposure to lead and late life abnormalities of nervous system,” Indian Journal of Experimental Biology, vol. 48, no. 7, pp. 636–641, 2010. View at Scopus
132. S. Chan and J. Rovet, “Thyroid hormones in fetal central nervous system development,” Fetal and Maternal Medicine Review, vol. 14, no. 3, pp. 177–208, 2003. View at Publisher · View at Google Scholar · View at Scopus
133. J. E. Haddow, G. E. Palomaki, W. C. Allan et al., “Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child,” The New England Journal of Medicine, vol. 341, no. 8, pp. 549–555, 1999. View at Publisher · View at Google Scholar · View at Scopus
134. R. T. Zoeller and K. M. Crofton, “Mode of action: developmental thyroid hormone insufficiency—Neurological abnormalities resulting from exposure to propylthiouracil,” Critical Reviews in Toxicology, vol. 35, no. 8-9, pp. 771–781, 2005. View at Publisher · View at Google Scholar · View at Scopus
135. M. E. Gilbert, “Impact of low-level thyroid hormone disruption induced by propylthiouracil on brain development and function,” The Journal of Toxicological Sciences, vol. 124, no. 2, pp. 432–445, 2011.
136. Y. Masuo and M. Ishido, “Neurotoxicity of endocrine disruptors: possible involvement in brain development and neurodegeneration,” Journal of Toxicology and Environmental Health B, vol. 14, no. 5–7, pp. 346–369, 2011. View at Publisher · View at Google Scholar · View at Scopus
137. K. Nakamura, K. Itoh, T. Sugimoto, and S. Fushiki, “Prenatal exposure to bisphenol A affects adult murine neocortical structure,” Neuroscience Letters, vol. 420, no. 2, pp. 100–105, 2007. View at Publisher · View at Google Scholar · View at Scopus
138. K. Nakamura, K. Itoh, H. Dai et al., “Prenatal and lactational exposure to low-doses of bisphenol A alters adult mice behavior,” Brain and Development, vol. 34, pp. 57–63, 2011. View at Publisher · View at Google Scholar · View at Scopus
139. H. Viberg, A. Fredriksson, S. Buratovic, and P. Eriksson, “Dose-dependent behavioral disturbances after a single neonatal bisphenol A dose,” Toxicology, vol. 290, pp. 188–195, 2011.
140. D. G. Stump, M. J. Beck, A. Radovsky et al., “Developmental neurotoxicity study of dietary bisphenol A in sprague-dawley rats,” Toxicological Sciences, vol. 115, no. 1, pp. 167–182, 2010. View at Publisher · View at Google Scholar · View at Scopus
141. NRC (National Research Council), Scientific Frontiers in Developmental Toxicology and Risk Assessment, National Academy Press, Washington, DC, USA, 2000.