Table 1: Change of body weight during the experimental period.BW Sham control Vehicle control CAPT P 31.25 P 62.5 P 125 LOSA Day 0(1)
1
8
1
.
6
3
±
8
.
2
8
1
8
2
.
5
0
±
1
0
.
4
2
1
8
3
.
3
8
±
6
.
9
5
1
7
9
.
7
5
±
6
.
1
4
1
8
0
.
2
5
±
6
.
2
5
1
7
8
.
7
5
±
6
.
8
4
1
7
8
.
2
5
±
7
3
2
7
Day 1(2)
1
6
4
.
3
8
±
7
.
1
9
1
6
6
.
7
5
±
7
.
8
0
1
6
5
.
5
0
±
6
.
4
8
1
6
2
.
7
5
±
5
.
8
5
1
6
2
.
6
3
±
5
.
4
5
1
6
4
.
0
0
±
5
.
1
8
1
6
2
.
2
5
±
5
.
6
0
Day 7
2
0
2
.
1
3
±
1
5
.
1
6
2
0
6
.
7
5
±
1
2
.
4
3
2
0
3
.
2
5
±
6
.
6
7
2
0
0
.
5
0
±
1
3
.
3
8
1
9
7
.
2
5
±
1
0
.
2
5
1
9
8
.
0
0
±
1
0
.
8
0
1
9
8
.
3
8
±
7
.
9
1
Day 14
2
1
5
.
7
5
±
1
6
.
1
8
2
2
1
.
7
5
±
1
2
.
3
4
2
1
6
.
5
0
±
1
1
.
1
1
2
1
8
.
5
0
±
1
4
.
3
0
2
1
7
.
1
3
±
1
0
.
8
3
2
1
1
.
8
8
±
7
.
0
8
2
1
3
.
2
5
±
9
.
8
1
Day 21
2
3
3
.
8
8
±
2
5
.
1
6
2
4
0
.
6
3
±
1
4
.
3
8
2
2
8
.
3
8
±
1
1
.
5
4
2
3
2
.
5
0
±
1
4
.
8
5
2
3
6
.
5
0
±
1
5
.
5
7
2
2
8
.
8
8
±
9
.
3
3
2
2
6
.
2
5
±
9
.
4
7
Day 27
2
4
1
.
1
3
±
2
4
.
0
9
2
4
9
.
1
3
±
2
2
.
9
7
2
2
9
.
6
3
±
1
5
.
6
4
2
3
7
.
8
8
±
1
3
.
2
3
2
3
9
.
8
8
±
1
3
.
0
4
2
3
9
.
2
5
±
8
.
4
8
2
3
6
.
5
0
±
1
1
.
4
8
Day 28(3)
2
2
6
.
7
5
±
2
2
.
2
6
2
3
4
.
1
3
±
2
0
.
3
6
2
2
2
.
5
0
±
1
1
.
0
6
2
2
4
.
3
8
±
1
3
.
6
2
2
2
7
.
8
8
±
1
2
.
8
0
2
2
4
.
7
5
±
6
.
0
9
2
2
3
.
5
0
±
9
.
0
6
Day 32
2
5
1
.
3
8
±
2
4
.
2
0
2
2
3
.
5
0
±
2
4
.
1
4
2
2
2
.
3
8
±
1
6
.
6
6
**
2
3
0
.
8
8
±
2
1
.
9
6
2
3
2
.
8
8
±
1
5
.
9
6
2
3
0
.
8
8
±
6
.
4
5
**
2
2
2
.
0
0
±
1
0
.
8
6
*
Day 33(4)
2
3
1
.
5
0
±
2
5
.
4
0
2
1
2
.
8
8
±
2
2
.
2
5
2
0
9
.
7
5
±
1
5
.
2
5
2
1
5
.
0
0
±
2
0
.
0
7
2
1
9
.
6
3
±
1
2
.
7
3
2
1
7
.
6
3
±
1
0
.
9
5
2
0
7
.
7
5
±
8
.
1
5
**
𝑛
=
8
; (Mean ± S.D., g); (1) One day before of test article administration; (2) first administration of test article after overnight fasted; (3) At CDDP-administration day after overnight fasted; (4) At euthanasia; *
𝑃
<
0
.
0
1
and **
𝑃
<
0
.
0
5
compared to sham by MW test.