The Biosynthesis of the Molybdenum Cofactor in Escherichia coli and Its Connection to FeS Cluster Assembly and the Thiolation of tRNA
Figure 12
Model for the connection of Moco biosynthesis, FeS cluster assembly, thiamine biosynthesis, and tRNA thiolation in E. coli. Shown is a general scheme for the sulfur mobilization by IscS, the interaction partners of IscS and the pathways for the synthesis of s4U and thiamine involving ThiI, FeS clusters assembly involving IscU, Moco biosynthesis involving TusA and YnjE, and s2U formation involving TusA. FeS clusters are also required for Moco biosynthesis, connecting both pathways. The acceptor proteins for Moco are shown in addition to their localization in the cell. Detailed descriptions are given in the text.
