Sodium Butyrate Plus EGF and PDGF-BB Aids Cutaneous Wound Healing in Diabetic Mice

Table 4

Wound closure in control and treated groups.

Serial number	Growth factor, Na-Bu application	Percentage wound closure on day 14 after wounding
(i)	Nondiabetic untreated control	100%
(ii)	Diabetic untreated control	<10%
(iii)	Diabetic wound + 2 mM Na-Bu daily from day 1 to day 14	<5%
(iv)	Diabetic wound + 10 ng EGF; daily, day 1 to day 14	40%
(v)	Diabetic wound + 10 ng EGF (for first 2 days); 10 ng EGF + 2 mM Na-Bu (for the following 12 days)	35%
(vi)	Diabetic wound + 15 ng PDGF-BB daily from day 1 to day 14	55%
(vii)	Diabetic wound + 15 ng PDGF-BB (for 2 days); 15 ng PDGF-BB + 2 mM Na-Bu (for the following 12 days)	60%
(viii)	Diabetic wound + 10 ng EGF + 15 ng PDGF-BB daily from day 1 to day 14	55%
(ix)	Diabetic wound + 10 ng EGF + 15 ng PDGF-BB (first 2 days) followed by the same growth factors + 2 mM Na-Bu daily from day 2 to day 14	>95%