Adaptive Evolution Hotspots at the GC-Extremes of the Human Genome: Evidence for Two Functionally Distinct Pathways of Positive Selection

<table>Ka/Ks profile of the human genome, showing that 75% of all genes are characterized by a Ka/Ks &lt; 0.2; that is, most are under negative selection, whereas only a small percentage is characterised by very high Ka/Ks.</table>

Advances in Bioinformatics

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Figure 1

Figure 1: Adaptive Evolution Hotspots at the GC-Extremes of the Human Genome: Evidence for Two Functionally Distinct Pathways of Positive Selection 