An Integrated Framework to Model Cellular Phenotype as a Component of Biochemical Networks

Table 3

In silico gene knock-down models predict the viability of experimental deletion of yeast cell cycle genes. Outcome of gene deletion experiments obtained from the Saccharomyces Genome Deletion Project [20]. Viability of in silico gene knock-down models assessed by the fit of the predicted to the observed fraction of budding cells. 14/17 predictions are correct. Incorrect predictions are marked in red.

Node	ORF	Experimental outcome	Model prediction
SIC1	YLR079W	Viable	Viable
CLB5	YPR120C	Viable	Viable
CDC20	YGL116W	Inviable	Inviable
CLN3	YAL040C	Viable	Viable
SWI6	YLR182W	Viable	Viable
CLN1	YMR199W	Viable	Viable
CLN2	YPL256C	Viable	Viable
CLB6	YGR109C	Viable	Viable
SWI4	YER111C	Viable	Viable
CDC28	YBR160W	Inviable	Inviable
MBP1	YDL056W	Viable	Viable
CDC6	YJL194W	Inviable	Viable
CLB1	YGR108W	Viable	Viable
CLB2	YPR119W	Viable	Viable
CDH1	YGL003C	Viable	Inviable
SWI5	YDR146C	Viable	Inviable
MCM1	YMR043W	Inviable	Inviable