Research Article
Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction: Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides
Table 2
Sequences of CD4 mimetic peptides. hCD4-M and mCD4-M represent the wild-type mimetic peptides presenting residues 22–64 of hCD4 and 22–66 of mCD4, respectively. Residues of hCD4-M and mCD4-M that were replaced by alanine in hCD4-M* and mCD4-M*, respectively, are shown in bold. mCD4-M** represents a cyclic peptide that was proposed based on the computational simulations. The position of the engineered disulfide bond is indicated by brackets next to the involved cysteine residues.
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*Ahx: ε-aminohexanoic acid (spacer between tag and peptide sequence). |