Research Article
Generation and Analysis of Large-Scale Data-Driven Mycobacterium tuberculosis Functional Networks for Drug Target Identification
Table 4
Repartition per class of potential drug target proteins, considering those which are central and those considered to be more influential.
| | Functional class | Proteins | Drug targets | Central targets | Influential targets |
| 1 | Virulence, detoxification, adaptation | 176 | 31 | 2 | 1 | 2 | Lipid metabolism | 230 | 75 | 35 | 28 | 3 | Information pathways | 245 | 85 | 21 | — | 4 | Cell wall and cell processes | 618 | 112 | 52 | 5 | 5 | Insertion seqs and phages | 82 | 10 | — | — | 6 | PE/PPE | 147 | 69 | 2 | — | 7 | Intermediary metabolism and respiration | 884 | 262 | 93 | 70 | 8 | Unknown | 1637 | 169 | 24 | 10 | 9 | Regulatory proteins | 176 | 68 | 12 | — |
| | Total | 4195 | 881 | 241 | 114 |
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